Time-resolved serial crystallography to reveal protein structural changes
Trends Biochem Sci. 2023 Oct 14:S0968-0004(23)00250-5. doi: 10.1016/j.tibs.2023.09.009. Online ahead of print.NO ABSTRACTPMID:37845135 | DOI:10.1016/j.tibs.2023.09.009 (Source: Trends in Biochemical Sciences)
Source: Trends in Biochemical Sciences - October 16, 2023 Category: Biochemistry Authors: Petra Meszaros Sebastian Westenhoff Source Type: research
Time-resolved serial crystallography to reveal protein structural changes
Trends Biochem Sci. 2023 Oct 14:S0968-0004(23)00250-5. doi: 10.1016/j.tibs.2023.09.009. Online ahead of print.NO ABSTRACTPMID:37845135 | DOI:10.1016/j.tibs.2023.09.009 (Source: Trends in Biochemical Sciences)
Source: Trends in Biochemical Sciences - October 16, 2023 Category: Biochemistry Authors: Petra Meszaros Sebastian Westenhoff Source Type: research
Confluence and convergence of Dscam and Pcdh cell-recognition codes
Trends Biochem Sci. 2023 Oct 13:S0968-0004(23)00227-X. doi: 10.1016/j.tibs.2023.09.001. Online ahead of print.ABSTRACTThe ability of neurites of the same neuron to avoid each other (self-avoidance) is a conserved feature in both invertebrates and vertebrates. The key to self-avoidance is the generation of a unique subset of cell-surface proteins in individual neurons engaging in isoform-specific homophilic interactions that drive neurite repulsion rather than adhesion. Among these cell-surface proteins are fly Dscam1 and vertebrate clustered protocadherins (cPcdhs), as well as the recently characterized shortened Dscam (sD...
Source: Trends in Biochemical Sciences - October 15, 2023 Category: Biochemistry Authors: Haiyang Dong Jinhuan Li Qiang Wu Yongfeng Jin Source Type: research
Confluence and convergence of Dscam and Pcdh cell-recognition codes
Trends Biochem Sci. 2023 Oct 13:S0968-0004(23)00227-X. doi: 10.1016/j.tibs.2023.09.001. Online ahead of print.ABSTRACTThe ability of neurites of the same neuron to avoid each other (self-avoidance) is a conserved feature in both invertebrates and vertebrates. The key to self-avoidance is the generation of a unique subset of cell-surface proteins in individual neurons engaging in isoform-specific homophilic interactions that drive neurite repulsion rather than adhesion. Among these cell-surface proteins are fly Dscam1 and vertebrate clustered protocadherins (cPcdhs), as well as the recently characterized shortened Dscam (sD...
Source: Trends in Biochemical Sciences - October 15, 2023 Category: Biochemistry Authors: Haiyang Dong Jinhuan Li Qiang Wu Yongfeng Jin Source Type: research
Using graphs and charts in scientific figures
Trends Biochem Sci. 2023 Nov;48(11):913-916. doi: 10.1016/j.tibs.2023.08.011.NO ABSTRACTPMID:37837963 | DOI:10.1016/j.tibs.2023.08.011 (Source: Trends in Biochemical Sciences)
Source: Trends in Biochemical Sciences - October 14, 2023 Category: Biochemistry Authors: Karol Buda Katerina Cermakova H Courtney Hodges Eugenio F Fornasiero Shahar Sukenik Alex S Holehouse Source Type: research
AI interprets the Central Dogma and Genetic Code
Trends Biochem Sci. 2023 Oct 11:S0968-0004(23)00230-X. doi: 10.1016/j.tibs.2023.09.004. Online ahead of print.ABSTRACTGenerative artificial intelligence (AI) is a burgeoning field with widespread applications, including in science. Here, we explore two paradigms that provide insight into the capabilities and limitations of Chat Generative Pre-trained Transformer (ChatGPT): its ability to (i) define a core biological concept (the Central Dogma of molecular biology); and (ii) interpret the genetic code.PMID:37833131 | DOI:10.1016/j.tibs.2023.09.004 (Source: Trends in Biochemical Sciences)
Source: Trends in Biochemical Sciences - October 13, 2023 Category: Biochemistry Authors: Alexander M Ille Michael B Mathews Source Type: research
AI interprets the Central Dogma and Genetic Code
Trends Biochem Sci. 2023 Oct 11:S0968-0004(23)00230-X. doi: 10.1016/j.tibs.2023.09.004. Online ahead of print.ABSTRACTGenerative artificial intelligence (AI) is a burgeoning field with widespread applications, including in science. Here, we explore two paradigms that provide insight into the capabilities and limitations of Chat Generative Pre-trained Transformer (ChatGPT): its ability to (i) define a core biological concept (the Central Dogma of molecular biology); and (ii) interpret the genetic code.PMID:37833131 | DOI:10.1016/j.tibs.2023.09.004 (Source: Trends in Biochemical Sciences)
Source: Trends in Biochemical Sciences - October 13, 2023 Category: Biochemistry Authors: Alexander M Ille Michael B Mathews Source Type: research
Two for one: regulatory RNAs that encode small proteins
Trends Biochem Sci. 2023 Sep 28:S0968-0004(23)00228-1. doi: 10.1016/j.tibs.2023.09.002. Online ahead of print.ABSTRACTRNAs are commonly categorized as being either protein-coding mRNAs or noncoding RNAs. However, an increasing number of transcripts, in organisms ranging from bacteria to humans, are being found to have both coding and noncoding functions. In some cases, the sequences encoding the protein and the regulatory RNA functions are separated, while in other cases the sequences overlap. The protein and RNA can regulate similar or distinct pathways. Here we describe examples illustrating how these dual-function (also...
Source: Trends in Biochemical Sciences - September 30, 2023 Category: Biochemistry Authors: Jordan J Aoyama Gisela Storz Source Type: research
Giant variations in giant virus genome packaging
Trends Biochem Sci. 2023 Sep 28:S0968-0004(23)00229-3. doi: 10.1016/j.tibs.2023.09.003. Online ahead of print.ABSTRACTGiant viruses (Nucleocytoviricota) have a largely conserved lifecycle, yet how they cram their large genomes into viral capsids is mostly unknown. The major capsid protein and the packaging ATPase (pATPase) comprise a highly conserved morphogenesis module in giant viruses, yet some giant viruses dispense with an icosahedral capsid, and others encode multiple versions of pATPases, including conjoined ATPase doublets, or encode none. Some giant viruses have acquired DNA-condensing proteins to compact their ge...
Source: Trends in Biochemical Sciences - September 30, 2023 Category: Biochemistry Authors: Paul B Talbert Steven Henikoff Karim-Jean Armache Source Type: research
Two for one: regulatory RNAs that encode small proteins
Trends Biochem Sci. 2023 Sep 28:S0968-0004(23)00228-1. doi: 10.1016/j.tibs.2023.09.002. Online ahead of print.ABSTRACTRNAs are commonly categorized as being either protein-coding mRNAs or noncoding RNAs. However, an increasing number of transcripts, in organisms ranging from bacteria to humans, are being found to have both coding and noncoding functions. In some cases, the sequences encoding the protein and the regulatory RNA functions are separated, while in other cases the sequences overlap. The protein and RNA can regulate similar or distinct pathways. Here we describe examples illustrating how these dual-function (also...
Source: Trends in Biochemical Sciences - September 30, 2023 Category: Biochemistry Authors: Jordan J Aoyama Gisela Storz Source Type: research
Giant variations in giant virus genome packaging
Trends Biochem Sci. 2023 Sep 28:S0968-0004(23)00229-3. doi: 10.1016/j.tibs.2023.09.003. Online ahead of print.ABSTRACTGiant viruses (Nucleocytoviricota) have a largely conserved lifecycle, yet how they cram their large genomes into viral capsids is mostly unknown. The major capsid protein and the packaging ATPase (pATPase) comprise a highly conserved morphogenesis module in giant viruses, yet some giant viruses dispense with an icosahedral capsid, and others encode multiple versions of pATPases, including conjoined ATPase doublets, or encode none. Some giant viruses have acquired DNA-condensing proteins to compact their ge...
Source: Trends in Biochemical Sciences - September 30, 2023 Category: Biochemistry Authors: Paul B Talbert Steven Henikoff Karim-Jean Armache Source Type: research
Two for one: regulatory RNAs that encode small proteins
Trends Biochem Sci. 2023 Sep 28:S0968-0004(23)00228-1. doi: 10.1016/j.tibs.2023.09.002. Online ahead of print.ABSTRACTRNAs are commonly categorized as being either protein-coding mRNAs or noncoding RNAs. However, an increasing number of transcripts, in organisms ranging from bacteria to humans, are being found to have both coding and noncoding functions. In some cases, the sequences encoding the protein and the regulatory RNA functions are separated, while in other cases the sequences overlap. The protein and RNA can regulate similar or distinct pathways. Here we describe examples illustrating how these dual-function (also...
Source: Trends in Biochemical Sciences - September 30, 2023 Category: Biochemistry Authors: Jordan J Aoyama Gisela Storz Source Type: research
Giant variations in giant virus genome packaging
Trends Biochem Sci. 2023 Sep 28:S0968-0004(23)00229-3. doi: 10.1016/j.tibs.2023.09.003. Online ahead of print.ABSTRACTGiant viruses (Nucleocytoviricota) have a largely conserved lifecycle, yet how they cram their large genomes into viral capsids is mostly unknown. The major capsid protein and the packaging ATPase (pATPase) comprise a highly conserved morphogenesis module in giant viruses, yet some giant viruses dispense with an icosahedral capsid, and others encode multiple versions of pATPases, including conjoined ATPase doublets, or encode none. Some giant viruses have acquired DNA-condensing proteins to compact their ge...
Source: Trends in Biochemical Sciences - September 30, 2023 Category: Biochemistry Authors: Paul B Talbert Steven Henikoff Karim-Jean Armache Source Type: research
Two for one: regulatory RNAs that encode small proteins
Trends Biochem Sci. 2023 Sep 28:S0968-0004(23)00228-1. doi: 10.1016/j.tibs.2023.09.002. Online ahead of print.ABSTRACTRNAs are commonly categorized as being either protein-coding mRNAs or noncoding RNAs. However, an increasing number of transcripts, in organisms ranging from bacteria to humans, are being found to have both coding and noncoding functions. In some cases, the sequences encoding the protein and the regulatory RNA functions are separated, while in other cases the sequences overlap. The protein and RNA can regulate similar or distinct pathways. Here we describe examples illustrating how these dual-function (also...
Source: Trends in Biochemical Sciences - September 30, 2023 Category: Biochemistry Authors: Jordan J Aoyama Gisela Storz Source Type: research
Giant variations in giant virus genome packaging
Trends Biochem Sci. 2023 Sep 28:S0968-0004(23)00229-3. doi: 10.1016/j.tibs.2023.09.003. Online ahead of print.ABSTRACTGiant viruses (Nucleocytoviricota) have a largely conserved lifecycle, yet how they cram their large genomes into viral capsids is mostly unknown. The major capsid protein and the packaging ATPase (pATPase) comprise a highly conserved morphogenesis module in giant viruses, yet some giant viruses dispense with an icosahedral capsid, and others encode multiple versions of pATPases, including conjoined ATPase doublets, or encode none. Some giant viruses have acquired DNA-condensing proteins to compact their ge...
Source: Trends in Biochemical Sciences - September 30, 2023 Category: Biochemistry Authors: Paul B Talbert Steven Henikoff Karim-Jean Armache Source Type: research
