Cotranslational sorting and processing of newly synthesized proteins in eukaryotes
Trends Biochem Sci. 2023 Nov 1:S0968-0004(23)00258-X. doi: 10.1016/j.tibs.2023.10.003. Online ahead of print.ABSTRACTRibosomes interact with a variety of different protein biogenesis factors that guide newly synthesized proteins to their native 3D shapes and cellular localization. Depending on the type of translated substrate, a distinct set of cotranslational factors must interact with the ribosome in a timely and coordinated manner to ensure proper protein biogenesis. While cytonuclear proteins require cotranslational maturation and folding factors, secretory proteins must be maintained in an unfolded state and processed...
Source: Trends in Biochemical Sciences - November 2, 2023 Category: Biochemistry Authors: Martin Gamerdinger Elke Deuerling Source Type: research
Cotranslational sorting and processing of newly synthesized proteins in eukaryotes
Trends Biochem Sci. 2023 Nov 1:S0968-0004(23)00258-X. doi: 10.1016/j.tibs.2023.10.003. Online ahead of print.ABSTRACTRibosomes interact with a variety of different protein biogenesis factors that guide newly synthesized proteins to their native 3D shapes and cellular localization. Depending on the type of translated substrate, a distinct set of cotranslational factors must interact with the ribosome in a timely and coordinated manner to ensure proper protein biogenesis. While cytonuclear proteins require cotranslational maturation and folding factors, secretory proteins must be maintained in an unfolded state and processed...
Source: Trends in Biochemical Sciences - November 2, 2023 Category: Biochemistry Authors: Martin Gamerdinger Elke Deuerling Source Type: research
Defining the commonalities between post-transcriptional and post-translational modification communities
Trends Biochem Sci. 2023 Oct 24:S0968-0004(23)00255-4. doi: 10.1016/j.tibs.2023.09.011. Online ahead of print.ABSTRACTPost-transcriptional modifications of RNA (PRMs) and post-translational modifications of proteins (PTMs) are important regulatory mechanisms in biological processes and have many commonalities. However, the integration of these research areas is lacking. A recent discussion identified the priorities, areas of emphasis, and necessary technologies to advance and integrate these areas of study.PMID:37884411 | DOI:10.1016/j.tibs.2023.09.011 (Source: Trends in Biochemical Sciences)
Source: Trends in Biochemical Sciences - October 26, 2023 Category: Biochemistry Authors: Zachary T Baumer Luke Erber Elizabeth Jolley Sheldon Lawrence Chuwei Lin Shino Murakami Veronica Perez Wil Prall Cassandra Schaening-Burgos Megan Sylvia Sixue Chen Brian D Gregory Source Type: research
Defining the commonalities between post-transcriptional and post-translational modification communities
Trends Biochem Sci. 2023 Oct 24:S0968-0004(23)00255-4. doi: 10.1016/j.tibs.2023.09.011. Online ahead of print.ABSTRACTPost-transcriptional modifications of RNA (PRMs) and post-translational modifications of proteins (PTMs) are important regulatory mechanisms in biological processes and have many commonalities. However, the integration of these research areas is lacking. A recent discussion identified the priorities, areas of emphasis, and necessary technologies to advance and integrate these areas of study.PMID:37884411 | DOI:10.1016/j.tibs.2023.09.011 (Source: Trends in Biochemical Sciences)
Source: Trends in Biochemical Sciences - October 26, 2023 Category: Biochemistry Authors: Zachary T Baumer Luke Erber Elizabeth Jolley Sheldon Lawrence Chuwei Lin Shino Murakami Veronica Perez Wil Prall Cassandra Schaening-Burgos Megan Sylvia Sixue Chen Brian D Gregory Source Type: research
Defining the commonalities between post-transcriptional and post-translational modification communities
Trends Biochem Sci. 2023 Oct 24:S0968-0004(23)00255-4. doi: 10.1016/j.tibs.2023.09.011. Online ahead of print.ABSTRACTPost-transcriptional modifications of RNA (PRMs) and post-translational modifications of proteins (PTMs) are important regulatory mechanisms in biological processes and have many commonalities. However, the integration of these research areas is lacking. A recent discussion identified the priorities, areas of emphasis, and necessary technologies to advance and integrate these areas of study.PMID:37884411 | DOI:10.1016/j.tibs.2023.09.011 (Source: Trends in Biochemical Sciences)
Source: Trends in Biochemical Sciences - October 26, 2023 Category: Biochemistry Authors: Zachary T Baumer Luke Erber Elizabeth Jolley Sheldon Lawrence Chuwei Lin Shino Murakami Veronica Perez Wil Prall Cassandra Schaening-Burgos Megan Sylvia Sixue Chen Brian D Gregory Source Type: research
Defining the commonalities between post-transcriptional and post-translational modification communities
Trends Biochem Sci. 2023 Oct 24:S0968-0004(23)00255-4. doi: 10.1016/j.tibs.2023.09.011. Online ahead of print.ABSTRACTPost-transcriptional modifications of RNA (PRMs) and post-translational modifications of proteins (PTMs) are important regulatory mechanisms in biological processes and have many commonalities. However, the integration of these research areas is lacking. A recent discussion identified the priorities, areas of emphasis, and necessary technologies to advance and integrate these areas of study.PMID:37884411 | DOI:10.1016/j.tibs.2023.09.011 (Source: Trends in Biochemical Sciences)
Source: Trends in Biochemical Sciences - October 26, 2023 Category: Biochemistry Authors: Zachary T Baumer Luke Erber Elizabeth Jolley Sheldon Lawrence Chuwei Lin Shino Murakami Veronica Perez Wil Prall Cassandra Schaening-Burgos Megan Sylvia Sixue Chen Brian D Gregory Source Type: research
Defining the commonalities between post-transcriptional and post-translational modification communities
Trends Biochem Sci. 2023 Oct 24:S0968-0004(23)00255-4. doi: 10.1016/j.tibs.2023.09.011. Online ahead of print.ABSTRACTPost-transcriptional modifications of RNA (PRMs) and post-translational modifications of proteins (PTMs) are important regulatory mechanisms in biological processes and have many commonalities. However, the integration of these research areas is lacking. A recent discussion identified the priorities, areas of emphasis, and necessary technologies to advance and integrate these areas of study.PMID:37884411 | DOI:10.1016/j.tibs.2023.09.011 (Source: Trends in Biochemical Sciences)
Source: Trends in Biochemical Sciences - October 26, 2023 Category: Biochemistry Authors: Zachary T Baumer Luke Erber Elizabeth Jolley Sheldon Lawrence Chuwei Lin Shino Murakami Veronica Perez Wil Prall Cassandra Schaening-Burgos Megan Sylvia Sixue Chen Brian D Gregory Source Type: research
Defining the commonalities between post-transcriptional and post-translational modification communities
Trends Biochem Sci. 2023 Oct 24:S0968-0004(23)00255-4. doi: 10.1016/j.tibs.2023.09.011. Online ahead of print.ABSTRACTPost-transcriptional modifications of RNA (PRMs) and post-translational modifications of proteins (PTMs) are important regulatory mechanisms in biological processes and have many commonalities. However, the integration of these research areas is lacking. A recent discussion identified the priorities, areas of emphasis, and necessary technologies to advance and integrate these areas of study.PMID:37884411 | DOI:10.1016/j.tibs.2023.09.011 (Source: Trends in Biochemical Sciences)
Source: Trends in Biochemical Sciences - October 26, 2023 Category: Biochemistry Authors: Zachary T Baumer Luke Erber Elizabeth Jolley Sheldon Lawrence Chuwei Lin Shino Murakami Veronica Perez Wil Prall Cassandra Schaening-Burgos Megan Sylvia Sixue Chen Brian D Gregory Source Type: research
Dynamics and logic of promoter melting
Trends Biochem Sci. 2023 Oct 18:S0968-0004(23)00251-7. doi: 10.1016/j.tibs.2023.09.010. Online ahead of print.ABSTRACTDespite significant progress in our understanding of promoter melting dynamics, underlying principles of the process remain elusive, with opposing views on key aspects held by many in the field. Here, I discuss the mechanistic logic behind the interplay of thermal and deterministic forces acting to create transcriptionally competent promoter complexes.PMID:37863673 | DOI:10.1016/j.tibs.2023.09.010 (Source: Trends in Biochemical Sciences)
Source: Trends in Biochemical Sciences - October 20, 2023 Category: Biochemistry Authors: Andrey Feklistov Source Type: research
Dynamics and logic of promoter melting
Trends Biochem Sci. 2023 Oct 18:S0968-0004(23)00251-7. doi: 10.1016/j.tibs.2023.09.010. Online ahead of print.ABSTRACTDespite significant progress in our understanding of promoter melting dynamics, underlying principles of the process remain elusive, with opposing views on key aspects held by many in the field. Here, I discuss the mechanistic logic behind the interplay of thermal and deterministic forces acting to create transcriptionally competent promoter complexes.PMID:37863673 | DOI:10.1016/j.tibs.2023.09.010 (Source: Trends in Biochemical Sciences)
Source: Trends in Biochemical Sciences - October 20, 2023 Category: Biochemistry Authors: Andrey Feklistov Source Type: research
Dynamics and logic of promoter melting
Trends Biochem Sci. 2023 Oct 18:S0968-0004(23)00251-7. doi: 10.1016/j.tibs.2023.09.010. Online ahead of print.ABSTRACTDespite significant progress in our understanding of promoter melting dynamics, underlying principles of the process remain elusive, with opposing views on key aspects held by many in the field. Here, I discuss the mechanistic logic behind the interplay of thermal and deterministic forces acting to create transcriptionally competent promoter complexes.PMID:37863673 | DOI:10.1016/j.tibs.2023.09.010 (Source: Trends in Biochemical Sciences)
Source: Trends in Biochemical Sciences - October 20, 2023 Category: Biochemistry Authors: Andrey Feklistov Source Type: research
Dynamics and logic of promoter melting
Trends Biochem Sci. 2023 Oct 18:S0968-0004(23)00251-7. doi: 10.1016/j.tibs.2023.09.010. Online ahead of print.ABSTRACTDespite significant progress in our understanding of promoter melting dynamics, underlying principles of the process remain elusive, with opposing views on key aspects held by many in the field. Here, I discuss the mechanistic logic behind the interplay of thermal and deterministic forces acting to create transcriptionally competent promoter complexes.PMID:37863673 | DOI:10.1016/j.tibs.2023.09.010 (Source: Trends in Biochemical Sciences)
Source: Trends in Biochemical Sciences - October 20, 2023 Category: Biochemistry Authors: Andrey Feklistov Source Type: research
Dynamics and logic of promoter melting
Trends Biochem Sci. 2023 Oct 18:S0968-0004(23)00251-7. doi: 10.1016/j.tibs.2023.09.010. Online ahead of print.ABSTRACTDespite significant progress in our understanding of promoter melting dynamics, underlying principles of the process remain elusive, with opposing views on key aspects held by many in the field. Here, I discuss the mechanistic logic behind the interplay of thermal and deterministic forces acting to create transcriptionally competent promoter complexes.PMID:37863673 | DOI:10.1016/j.tibs.2023.09.010 (Source: Trends in Biochemical Sciences)
Source: Trends in Biochemical Sciences - October 20, 2023 Category: Biochemistry Authors: Andrey Feklistov Source Type: research
Time-resolved serial crystallography to reveal protein structural changes
Trends Biochem Sci. 2023 Oct 14:S0968-0004(23)00250-5. doi: 10.1016/j.tibs.2023.09.009. Online ahead of print.NO ABSTRACTPMID:37845135 | DOI:10.1016/j.tibs.2023.09.009 (Source: Trends in Biochemical Sciences)
Source: Trends in Biochemical Sciences - October 16, 2023 Category: Biochemistry Authors: Petra Meszaros Sebastian Westenhoff Source Type: research
Time-resolved serial crystallography to reveal protein structural changes
Trends Biochem Sci. 2023 Oct 14:S0968-0004(23)00250-5. doi: 10.1016/j.tibs.2023.09.009. Online ahead of print.NO ABSTRACTPMID:37845135 | DOI:10.1016/j.tibs.2023.09.009 (Source: Trends in Biochemical Sciences)
Source: Trends in Biochemical Sciences - October 16, 2023 Category: Biochemistry Authors: Petra Meszaros Sebastian Westenhoff Source Type: research
