Dynamics and logic of promoter melting

Trends Biochem Sci. 2023 Oct 18:S0968-0004(23)00251-7. doi: 10.1016/j.tibs.2023.09.010. Online ahead of print.ABSTRACTDespite significant progress in our understanding of promoter melting dynamics, underlying principles of the process remain elusive, with opposing views on key aspects held by many in the field. Here, I discuss the mechanistic logic behind the interplay of thermal and deterministic forces acting to create transcriptionally competent promoter complexes.PMID:37863673 | DOI:10.1016/j.tibs.2023.09.010

Source: Trends in Biochemical Sciences - October 20, 2023 Category: Biochemistry Authors: Andrey Feklistov Source Type: research