Elucidating the novel mechanisms of molecular chaperones by single-molecule technologies
Trends Biochem Sci. 2023 Nov 16:S0968-0004(23)00281-5. doi: 10.1016/j.tibs.2023.10.009. Online ahead of print.ABSTRACTMolecular chaperones play central roles in sustaining protein homeostasis and preventing protein aggregation. Most studies of these systems have been performed in bulk, providing averaged measurements, though recent single-molecule approaches have provided an in-depth understanding of the molecular mechanisms of their activities and structural rearrangements during substrate recognition. Chaperone activities have been observed to be substrate specific, with some associated with ATP-dependent structural dyna...
Source: Trends in Biochemical Sciences - November 18, 2023 Category: Biochemistry Authors: Ayush Chandrakant Mistry Debojyoti Chowdhury Soham Chakraborty Shubhasis Haldar Source Type: research
The ART of RNAylation: covalent RNA-protein linkage in bacteriophage infection
Trends Biochem Sci. 2023 Nov 16:S0968-0004(23)00284-0. doi: 10.1016/j.tibs.2023.10.011. Online ahead of print.ABSTRACTBacteriophages have been a treasure trove for the discovery of fundamental biological principles and the expansion of our enzymatic toolkit since the dawn of molecular biology. In a recent study by Wolfram-Schauerte et al. these ubiquitous bacteria-infecting viruses reveal yet another new biological concept: post-translational modification through covalent RNA-protein linkages.PMID:37980188 | DOI:10.1016/j.tibs.2023.10.011 (Source: Trends in Biochemical Sciences)
Source: Trends in Biochemical Sciences - November 18, 2023 Category: Biochemistry Authors: Sophie M Korn Sunny Sharma Anna-Lena Steckelberg Source Type: research
Elucidating the novel mechanisms of molecular chaperones by single-molecule technologies
Trends Biochem Sci. 2023 Nov 16:S0968-0004(23)00281-5. doi: 10.1016/j.tibs.2023.10.009. Online ahead of print.ABSTRACTMolecular chaperones play central roles in sustaining protein homeostasis and preventing protein aggregation. Most studies of these systems have been performed in bulk, providing averaged measurements, though recent single-molecule approaches have provided an in-depth understanding of the molecular mechanisms of their activities and structural rearrangements during substrate recognition. Chaperone activities have been observed to be substrate specific, with some associated with ATP-dependent structural dyna...
Source: Trends in Biochemical Sciences - November 18, 2023 Category: Biochemistry Authors: Ayush Chandrakant Mistry Debojyoti Chowdhury Soham Chakraborty Shubhasis Haldar Source Type: research
The ART of RNAylation: covalent RNA-protein linkage in bacteriophage infection
Trends Biochem Sci. 2023 Nov 16:S0968-0004(23)00284-0. doi: 10.1016/j.tibs.2023.10.011. Online ahead of print.ABSTRACTBacteriophages have been a treasure trove for the discovery of fundamental biological principles and the expansion of our enzymatic toolkit since the dawn of molecular biology. In a recent study by Wolfram-Schauerte et al. these ubiquitous bacteria-infecting viruses reveal yet another new biological concept: post-translational modification through covalent RNA-protein linkages.PMID:37980188 | DOI:10.1016/j.tibs.2023.10.011 (Source: Trends in Biochemical Sciences)
Source: Trends in Biochemical Sciences - November 18, 2023 Category: Biochemistry Authors: Sophie M Korn Sunny Sharma Anna-Lena Steckelberg Source Type: research
Elucidating the novel mechanisms of molecular chaperones by single-molecule technologies
Trends Biochem Sci. 2023 Nov 16:S0968-0004(23)00281-5. doi: 10.1016/j.tibs.2023.10.009. Online ahead of print.ABSTRACTMolecular chaperones play central roles in sustaining protein homeostasis and preventing protein aggregation. Most studies of these systems have been performed in bulk, providing averaged measurements, though recent single-molecule approaches have provided an in-depth understanding of the molecular mechanisms of their activities and structural rearrangements during substrate recognition. Chaperone activities have been observed to be substrate specific, with some associated with ATP-dependent structural dyna...
Source: Trends in Biochemical Sciences - November 18, 2023 Category: Biochemistry Authors: Ayush Chandrakant Mistry Debojyoti Chowdhury Soham Chakraborty Shubhasis Haldar Source Type: research
The ART of RNAylation: covalent RNA-protein linkage in bacteriophage infection
Trends Biochem Sci. 2023 Nov 16:S0968-0004(23)00284-0. doi: 10.1016/j.tibs.2023.10.011. Online ahead of print.ABSTRACTBacteriophages have been a treasure trove for the discovery of fundamental biological principles and the expansion of our enzymatic toolkit since the dawn of molecular biology. In a recent study by Wolfram-Schauerte et al. these ubiquitous bacteria-infecting viruses reveal yet another new biological concept: post-translational modification through covalent RNA-protein linkages.PMID:37980188 | DOI:10.1016/j.tibs.2023.10.011 (Source: Trends in Biochemical Sciences)
Source: Trends in Biochemical Sciences - November 18, 2023 Category: Biochemistry Authors: Sophie M Korn Sunny Sharma Anna-Lena Steckelberg Source Type: research
Elucidating the novel mechanisms of molecular chaperones by single-molecule technologies
Trends Biochem Sci. 2023 Nov 16:S0968-0004(23)00281-5. doi: 10.1016/j.tibs.2023.10.009. Online ahead of print.ABSTRACTMolecular chaperones play central roles in sustaining protein homeostasis and preventing protein aggregation. Most studies of these systems have been performed in bulk, providing averaged measurements, though recent single-molecule approaches have provided an in-depth understanding of the molecular mechanisms of their activities and structural rearrangements during substrate recognition. Chaperone activities have been observed to be substrate specific, with some associated with ATP-dependent structural dyna...
Source: Trends in Biochemical Sciences - November 18, 2023 Category: Biochemistry Authors: Ayush Chandrakant Mistry Debojyoti Chowdhury Soham Chakraborty Shubhasis Haldar Source Type: research
The ART of RNAylation: covalent RNA-protein linkage in bacteriophage infection
Trends Biochem Sci. 2023 Nov 16:S0968-0004(23)00284-0. doi: 10.1016/j.tibs.2023.10.011. Online ahead of print.ABSTRACTBacteriophages have been a treasure trove for the discovery of fundamental biological principles and the expansion of our enzymatic toolkit since the dawn of molecular biology. In a recent study by Wolfram-Schauerte et al. these ubiquitous bacteria-infecting viruses reveal yet another new biological concept: post-translational modification through covalent RNA-protein linkages.PMID:37980188 | DOI:10.1016/j.tibs.2023.10.011 (Source: Trends in Biochemical Sciences)
Source: Trends in Biochemical Sciences - November 18, 2023 Category: Biochemistry Authors: Sophie M Korn Sunny Sharma Anna-Lena Steckelberg Source Type: research
Team science: building, nurturing, and expanding research collaborations
This article focuses on key aspects of initiating and sustaining new collaborations, and expanding from bilateral to multilateral efforts to create major impact through team science.PMID:37953092 | DOI:10.1016/j.tibs.2023.10.010 (Source: Trends in Biochemical Sciences)
Source: Trends in Biochemical Sciences - November 12, 2023 Category: Biochemistry Authors: Arun K Shukla Source Type: research
Team science: building, nurturing, and expanding research collaborations
This article focuses on key aspects of initiating and sustaining new collaborations, and expanding from bilateral to multilateral efforts to create major impact through team science.PMID:37953092 | DOI:10.1016/j.tibs.2023.10.010 (Source: Trends in Biochemical Sciences)
Source: Trends in Biochemical Sciences - November 12, 2023 Category: Biochemistry Authors: Arun K Shukla Source Type: research
Team science: building, nurturing, and expanding research collaborations
This article focuses on key aspects of initiating and sustaining new collaborations, and expanding from bilateral to multilateral efforts to create major impact through team science.PMID:37953092 | DOI:10.1016/j.tibs.2023.10.010 (Source: Trends in Biochemical Sciences)
Source: Trends in Biochemical Sciences - November 12, 2023 Category: Biochemistry Authors: Arun K Shukla Source Type: research
Team science: building, nurturing, and expanding research collaborations
This article focuses on key aspects of initiating and sustaining new collaborations, and expanding from bilateral to multilateral efforts to create major impact through team science.PMID:37953092 | DOI:10.1016/j.tibs.2023.10.010 (Source: Trends in Biochemical Sciences)
Source: Trends in Biochemical Sciences - November 12, 2023 Category: Biochemistry Authors: Arun K Shukla Source Type: research
Team science: building, nurturing, and expanding research collaborations
This article focuses on key aspects of initiating and sustaining new collaborations, and expanding from bilateral to multilateral efforts to create major impact through team science.PMID:37953092 | DOI:10.1016/j.tibs.2023.10.010 (Source: Trends in Biochemical Sciences)
Source: Trends in Biochemical Sciences - November 12, 2023 Category: Biochemistry Authors: Arun K Shukla Source Type: research
Wrapping up a special series on scientific figure development
Trends Biochem Sci. 2023 Dec;48(12):1007-1008. doi: 10.1016/j.tibs.2023.09.008.NO ABSTRACTPMID:37949051 | DOI:10.1016/j.tibs.2023.09.008 (Source: Trends in Biochemical Sciences)
Source: Trends in Biochemical Sciences - November 10, 2023 Category: Biochemistry Authors: Sannie Culbertson Source Type: research
Turning science into cover art
Trends Biochem Sci. 2023 Dec;48(12):1009-1011. doi: 10.1016/j.tibs.2023.09.006.NO ABSTRACTPMID:37949052 | DOI:10.1016/j.tibs.2023.09.006 (Source: Trends in Biochemical Sciences)
Source: Trends in Biochemical Sciences - November 10, 2023 Category: Biochemistry Authors: Helen Dauben Ivan Matic Rune Thomas Kidmose Bj ørn Panyella Pedersen Tannishtha Saha Michela Di Virgilio Julie Ho Sung Source Type: research
