Two for one: regulatory RNAs that encode small proteins
Trends Biochem Sci. 2023 Sep 28:S0968-0004(23)00228-1. doi: 10.1016/j.tibs.2023.09.002. Online ahead of print.ABSTRACTRNAs are commonly categorized as being either protein-coding mRNAs or noncoding RNAs. However, an increasing number of transcripts, in organisms ranging from bacteria to humans, are being found to have both coding and noncoding functions. In some cases, the sequences encoding the protein and the regulatory RNA functions are separated, while in other cases the sequences overlap. The protein and RNA can regulate similar or distinct pathways. Here we describe examples illustrating how these dual-function (also...
Source: Trends in Biochemical Sciences - September 30, 2023 Category: Biochemistry Authors: Jordan J Aoyama Gisela Storz Source Type: research
Giant variations in giant virus genome packaging
Trends Biochem Sci. 2023 Sep 28:S0968-0004(23)00229-3. doi: 10.1016/j.tibs.2023.09.003. Online ahead of print.ABSTRACTGiant viruses (Nucleocytoviricota) have a largely conserved lifecycle, yet how they cram their large genomes into viral capsids is mostly unknown. The major capsid protein and the packaging ATPase (pATPase) comprise a highly conserved morphogenesis module in giant viruses, yet some giant viruses dispense with an icosahedral capsid, and others encode multiple versions of pATPases, including conjoined ATPase doublets, or encode none. Some giant viruses have acquired DNA-condensing proteins to compact their ge...
Source: Trends in Biochemical Sciences - September 30, 2023 Category: Biochemistry Authors: Paul B Talbert Steven Henikoff Karim-Jean Armache Source Type: research
Two for one: regulatory RNAs that encode small proteins
Trends Biochem Sci. 2023 Sep 28:S0968-0004(23)00228-1. doi: 10.1016/j.tibs.2023.09.002. Online ahead of print.ABSTRACTRNAs are commonly categorized as being either protein-coding mRNAs or noncoding RNAs. However, an increasing number of transcripts, in organisms ranging from bacteria to humans, are being found to have both coding and noncoding functions. In some cases, the sequences encoding the protein and the regulatory RNA functions are separated, while in other cases the sequences overlap. The protein and RNA can regulate similar or distinct pathways. Here we describe examples illustrating how these dual-function (also...
Source: Trends in Biochemical Sciences - September 30, 2023 Category: Biochemistry Authors: Jordan J Aoyama Gisela Storz Source Type: research
Giant variations in giant virus genome packaging
Trends Biochem Sci. 2023 Sep 28:S0968-0004(23)00229-3. doi: 10.1016/j.tibs.2023.09.003. Online ahead of print.ABSTRACTGiant viruses (Nucleocytoviricota) have a largely conserved lifecycle, yet how they cram their large genomes into viral capsids is mostly unknown. The major capsid protein and the packaging ATPase (pATPase) comprise a highly conserved morphogenesis module in giant viruses, yet some giant viruses dispense with an icosahedral capsid, and others encode multiple versions of pATPases, including conjoined ATPase doublets, or encode none. Some giant viruses have acquired DNA-condensing proteins to compact their ge...
Source: Trends in Biochemical Sciences - September 30, 2023 Category: Biochemistry Authors: Paul B Talbert Steven Henikoff Karim-Jean Armache Source Type: research
Two for one: regulatory RNAs that encode small proteins
Trends Biochem Sci. 2023 Sep 28:S0968-0004(23)00228-1. doi: 10.1016/j.tibs.2023.09.002. Online ahead of print.ABSTRACTRNAs are commonly categorized as being either protein-coding mRNAs or noncoding RNAs. However, an increasing number of transcripts, in organisms ranging from bacteria to humans, are being found to have both coding and noncoding functions. In some cases, the sequences encoding the protein and the regulatory RNA functions are separated, while in other cases the sequences overlap. The protein and RNA can regulate similar or distinct pathways. Here we describe examples illustrating how these dual-function (also...
Source: Trends in Biochemical Sciences - September 30, 2023 Category: Biochemistry Authors: Jordan J Aoyama Gisela Storz Source Type: research
Giant variations in giant virus genome packaging
Trends Biochem Sci. 2023 Sep 28:S0968-0004(23)00229-3. doi: 10.1016/j.tibs.2023.09.003. Online ahead of print.ABSTRACTGiant viruses (Nucleocytoviricota) have a largely conserved lifecycle, yet how they cram their large genomes into viral capsids is mostly unknown. The major capsid protein and the packaging ATPase (pATPase) comprise a highly conserved morphogenesis module in giant viruses, yet some giant viruses dispense with an icosahedral capsid, and others encode multiple versions of pATPases, including conjoined ATPase doublets, or encode none. Some giant viruses have acquired DNA-condensing proteins to compact their ge...
Source: Trends in Biochemical Sciences - September 30, 2023 Category: Biochemistry Authors: Paul B Talbert Steven Henikoff Karim-Jean Armache Source Type: research
Two for one: regulatory RNAs that encode small proteins
Trends Biochem Sci. 2023 Sep 28:S0968-0004(23)00228-1. doi: 10.1016/j.tibs.2023.09.002. Online ahead of print.ABSTRACTRNAs are commonly categorized as being either protein-coding mRNAs or noncoding RNAs. However, an increasing number of transcripts, in organisms ranging from bacteria to humans, are being found to have both coding and noncoding functions. In some cases, the sequences encoding the protein and the regulatory RNA functions are separated, while in other cases the sequences overlap. The protein and RNA can regulate similar or distinct pathways. Here we describe examples illustrating how these dual-function (also...
Source: Trends in Biochemical Sciences - September 30, 2023 Category: Biochemistry Authors: Jordan J Aoyama Gisela Storz Source Type: research
Giant variations in giant virus genome packaging
Trends Biochem Sci. 2023 Sep 28:S0968-0004(23)00229-3. doi: 10.1016/j.tibs.2023.09.003. Online ahead of print.ABSTRACTGiant viruses (Nucleocytoviricota) have a largely conserved lifecycle, yet how they cram their large genomes into viral capsids is mostly unknown. The major capsid protein and the packaging ATPase (pATPase) comprise a highly conserved morphogenesis module in giant viruses, yet some giant viruses dispense with an icosahedral capsid, and others encode multiple versions of pATPases, including conjoined ATPase doublets, or encode none. Some giant viruses have acquired DNA-condensing proteins to compact their ge...
Source: Trends in Biochemical Sciences - September 30, 2023 Category: Biochemistry Authors: Paul B Talbert Steven Henikoff Karim-Jean Armache Source Type: research
Two for one: regulatory RNAs that encode small proteins
Trends Biochem Sci. 2023 Sep 28:S0968-0004(23)00228-1. doi: 10.1016/j.tibs.2023.09.002. Online ahead of print.ABSTRACTRNAs are commonly categorized as being either protein-coding mRNAs or noncoding RNAs. However, an increasing number of transcripts, in organisms ranging from bacteria to humans, are being found to have both coding and noncoding functions. In some cases, the sequences encoding the protein and the regulatory RNA functions are separated, while in other cases the sequences overlap. The protein and RNA can regulate similar or distinct pathways. Here we describe examples illustrating how these dual-function (also...
Source: Trends in Biochemical Sciences - September 30, 2023 Category: Biochemistry Authors: Jordan J Aoyama Gisela Storz Source Type: research
Giant variations in giant virus genome packaging
Trends Biochem Sci. 2023 Sep 28:S0968-0004(23)00229-3. doi: 10.1016/j.tibs.2023.09.003. Online ahead of print.ABSTRACTGiant viruses (Nucleocytoviricota) have a largely conserved lifecycle, yet how they cram their large genomes into viral capsids is mostly unknown. The major capsid protein and the packaging ATPase (pATPase) comprise a highly conserved morphogenesis module in giant viruses, yet some giant viruses dispense with an icosahedral capsid, and others encode multiple versions of pATPases, including conjoined ATPase doublets, or encode none. Some giant viruses have acquired DNA-condensing proteins to compact their ge...
Source: Trends in Biochemical Sciences - September 30, 2023 Category: Biochemistry Authors: Paul B Talbert Steven Henikoff Karim-Jean Armache Source Type: research
Two for one: regulatory RNAs that encode small proteins
Trends Biochem Sci. 2023 Sep 28:S0968-0004(23)00228-1. doi: 10.1016/j.tibs.2023.09.002. Online ahead of print.ABSTRACTRNAs are commonly categorized as being either protein-coding mRNAs or noncoding RNAs. However, an increasing number of transcripts, in organisms ranging from bacteria to humans, are being found to have both coding and noncoding functions. In some cases, the sequences encoding the protein and the regulatory RNA functions are separated, while in other cases the sequences overlap. The protein and RNA can regulate similar or distinct pathways. Here we describe examples illustrating how these dual-function (also...
Source: Trends in Biochemical Sciences - September 30, 2023 Category: Biochemistry Authors: Jordan J Aoyama Gisela Storz Source Type: research
Giant variations in giant virus genome packaging
Trends Biochem Sci. 2023 Sep 28:S0968-0004(23)00229-3. doi: 10.1016/j.tibs.2023.09.003. Online ahead of print.ABSTRACTGiant viruses (Nucleocytoviricota) have a largely conserved lifecycle, yet how they cram their large genomes into viral capsids is mostly unknown. The major capsid protein and the packaging ATPase (pATPase) comprise a highly conserved morphogenesis module in giant viruses, yet some giant viruses dispense with an icosahedral capsid, and others encode multiple versions of pATPases, including conjoined ATPase doublets, or encode none. Some giant viruses have acquired DNA-condensing proteins to compact their ge...
Source: Trends in Biochemical Sciences - September 30, 2023 Category: Biochemistry Authors: Paul B Talbert Steven Henikoff Karim-Jean Armache Source Type: research
DNA segregation in mitochondria and beyond: insights from the trypanosomal tripartite attachment complex
Trends Biochem Sci. 2023 Sep 27:S0968-0004(23)00224-4. doi: 10.1016/j.tibs.2023.08.012. Online ahead of print.ABSTRACTThe tripartite attachment complex (TAC) of the single mitochondrion of trypanosomes allows precise segregation of its single nucleoid mitochondrial genome during cytokinesis. It couples the segregation of the duplicated mitochondrial genome to the segregation of the basal bodies of the flagella. Here, we provide a model of the molecular architecture of the TAC that explains how its eight essential subunits connect the basal body, across the mitochondrial membranes, with the mitochondrial genome. We also dis...
Source: Trends in Biochemical Sciences - September 29, 2023 Category: Biochemistry Authors: Salome Aeschlimann Philip Stettler Andr é Schneider Source Type: research
Transcription and replication: walking a genomic tightrope hand-in-hand
Trends Biochem Sci. 2023 Sep 27:S0968-0004(23)00248-7. doi: 10.1016/j.tibs.2023.09.007. Online ahead of print.ABSTRACTA recent study by Fenstermaker et al. in Nature describes how transcriptionally active RNA polymerase II (Pol II) clings to the genomic tightrope during the passage of the replication fork and rapidly resumes transcription of immature RNA from both strands of nascent DNA, facilitated by protein-protein interactions between the replication and transcription machineries.PMID:37775422 | DOI:10.1016/j.tibs.2023.09.007 (Source: Trends in Biochemical Sciences)
Source: Trends in Biochemical Sciences - September 29, 2023 Category: Biochemistry Authors: George Yakoub Martijn S Luijsterburg Source Type: research
DNA segregation in mitochondria and beyond: insights from the trypanosomal tripartite attachment complex
Trends Biochem Sci. 2023 Sep 27:S0968-0004(23)00224-4. doi: 10.1016/j.tibs.2023.08.012. Online ahead of print.ABSTRACTThe tripartite attachment complex (TAC) of the single mitochondrion of trypanosomes allows precise segregation of its single nucleoid mitochondrial genome during cytokinesis. It couples the segregation of the duplicated mitochondrial genome to the segregation of the basal bodies of the flagella. Here, we provide a model of the molecular architecture of the TAC that explains how its eight essential subunits connect the basal body, across the mitochondrial membranes, with the mitochondrial genome. We also dis...
Source: Trends in Biochemical Sciences - September 29, 2023 Category: Biochemistry Authors: Salome Aeschlimann Philip Stettler Andr é Schneider Source Type: research
