Transcription factor IID parks and drives preinitiation complexes at sharp or broad promoters
Trends Biochem Sci. 2023 Aug 11:S0968-0004(23)00175-5. doi: 10.1016/j.tibs.2023.07.009. Online ahead of print.ABSTRACTCore promoters are sites where transcriptional regulatory inputs of a gene are integrated to direct the assembly of the preinitiation complex (PIC) and RNA polymerase II (Pol II) transcription output. Until now, core promoter functions have been investigated by distinct methods, including Pol II transcription initiation site mappings and structural characterization of PICs on distinct promoters. Here, we bring together these previously unconnected observations and hypothesize how, on metazoan TATA promoters...
Source: Trends in Biochemical Sciences - August 13, 2023 Category: Biochemistry Authors: Andrea Bernardini Camille Hollinger Damaris Willgenss Ferenc M üller Didier Devys L ászló Tora Source Type: research
Substrate recognition and transport mechanism of the PIN-FORMED auxin exporters
Trends Biochem Sci. 2023 Aug 11:S0968-0004(23)00172-X. doi: 10.1016/j.tibs.2023.07.006. Online ahead of print.ABSTRACTAuxins are pivotal plant hormones that regulate plant growth and transmembrane polar auxin transport (PAT) direct patterns of development. The PIN-FORMED (PIN) family of membrane transporters mediate auxin export from the plant cell and play crucial roles in PAT. Here we describe the recently solved structures of PIN transporters, PIN1, PIN3, and PIN8, and also their mechanisms of substrate recognition and transport of auxin. We compare structures of PINs in both inward- and outward-facing conformations, as...
Source: Trends in Biochemical Sciences - August 13, 2023 Category: Biochemistry Authors: Kien Lam Ung Lukas Schulz David L Stokes Ulrich Z Hammes Bj ørn Panyella Pedersen Source Type: research
Transcription factor IID parks and drives preinitiation complexes at sharp or broad promoters
Trends Biochem Sci. 2023 Aug 11:S0968-0004(23)00175-5. doi: 10.1016/j.tibs.2023.07.009. Online ahead of print.ABSTRACTCore promoters are sites where transcriptional regulatory inputs of a gene are integrated to direct the assembly of the preinitiation complex (PIC) and RNA polymerase II (Pol II) transcription output. Until now, core promoter functions have been investigated by distinct methods, including Pol II transcription initiation site mappings and structural characterization of PICs on distinct promoters. Here, we bring together these previously unconnected observations and hypothesize how, on metazoan TATA promoters...
Source: Trends in Biochemical Sciences - August 13, 2023 Category: Biochemistry Authors: Andrea Bernardini Camille Hollinger Damaris Willgenss Ferenc M üller Didier Devys L ászló Tora Source Type: research
Substrate recognition and transport mechanism of the PIN-FORMED auxin exporters
Trends Biochem Sci. 2023 Aug 11:S0968-0004(23)00172-X. doi: 10.1016/j.tibs.2023.07.006. Online ahead of print.ABSTRACTAuxins are pivotal plant hormones that regulate plant growth and transmembrane polar auxin transport (PAT) direct patterns of development. The PIN-FORMED (PIN) family of membrane transporters mediate auxin export from the plant cell and play crucial roles in PAT. Here we describe the recently solved structures of PIN transporters, PIN1, PIN3, and PIN8, and also their mechanisms of substrate recognition and transport of auxin. We compare structures of PINs in both inward- and outward-facing conformations, as...
Source: Trends in Biochemical Sciences - August 13, 2023 Category: Biochemistry Authors: Kien Lam Ung Lukas Schulz David L Stokes Ulrich Z Hammes Bj ørn Panyella Pedersen Source Type: research
Transcription factor IID parks and drives preinitiation complexes at sharp or broad promoters
Trends Biochem Sci. 2023 Aug 11:S0968-0004(23)00175-5. doi: 10.1016/j.tibs.2023.07.009. Online ahead of print.ABSTRACTCore promoters are sites where transcriptional regulatory inputs of a gene are integrated to direct the assembly of the preinitiation complex (PIC) and RNA polymerase II (Pol II) transcription output. Until now, core promoter functions have been investigated by distinct methods, including Pol II transcription initiation site mappings and structural characterization of PICs on distinct promoters. Here, we bring together these previously unconnected observations and hypothesize how, on metazoan TATA promoters...
Source: Trends in Biochemical Sciences - August 13, 2023 Category: Biochemistry Authors: Andrea Bernardini Camille Hollinger Damaris Willgenss Ferenc M üller Didier Devys L ászló Tora Source Type: research
