Transcription and replication: walking a genomic tightrope hand-in-hand
Trends Biochem Sci. 2023 Sep 27:S0968-0004(23)00248-7. doi: 10.1016/j.tibs.2023.09.007. Online ahead of print.ABSTRACTA recent study by Fenstermaker et al. in Nature describes how transcriptionally active RNA polymerase II (Pol II) clings to the genomic tightrope during the passage of the replication fork and rapidly resumes transcription of immature RNA from both strands of nascent DNA, facilitated by protein-protein interactions between the replication and transcription machineries.PMID:37775422 | DOI:10.1016/j.tibs.2023.09.007 (Source: Trends in Biochemical Sciences)
Source: Trends in Biochemical Sciences - September 29, 2023 Category: Biochemistry Authors: George Yakoub Martijn S Luijsterburg Source Type: research
Microbial gatekeepers: unraveling the role of the gut microbiota enzyme DPP4 in diabetes management
Trends Biochem Sci. 2023 Sep 26:S0968-0004(23)00231-1. doi: 10.1016/j.tibs.2023.09.005. Online ahead of print.ABSTRACTWang et al. identified dipeptidyl peptidase 4 (DPP4) as a gut microbe-derived enzyme that impacts on host glucose metabolism. They further introduced a novel therapeutic, daurisoline-d4 (Dau-d4), a selective microbial DPP4 (mDPP4) inhibitor that shows promise in improving glucose tolerance, highlighting the potential of therapies that target both host enzymes and gut microbial enzymes.PMID:37770288 | DOI:10.1016/j.tibs.2023.09.005 (Source: Trends in Biochemical Sciences)
Source: Trends in Biochemical Sciences - September 28, 2023 Category: Biochemistry Authors: Lijuan Liao Fan Lin Jiangtao Gao Source Type: research
Microbial gatekeepers: unraveling the role of the gut microbiota enzyme DPP4 in diabetes management
Trends Biochem Sci. 2023 Sep 26:S0968-0004(23)00231-1. doi: 10.1016/j.tibs.2023.09.005. Online ahead of print.ABSTRACTWang et al. identified dipeptidyl peptidase 4 (DPP4) as a gut microbe-derived enzyme that impacts on host glucose metabolism. They further introduced a novel therapeutic, daurisoline-d4 (Dau-d4), a selective microbial DPP4 (mDPP4) inhibitor that shows promise in improving glucose tolerance, highlighting the potential of therapies that target both host enzymes and gut microbial enzymes.PMID:37770288 | DOI:10.1016/j.tibs.2023.09.005 (Source: Trends in Biochemical Sciences)
Source: Trends in Biochemical Sciences - September 28, 2023 Category: Biochemistry Authors: Lijuan Liao Fan Lin Jiangtao Gao Source Type: research
Conserved structures of ESCRT-III superfamily members across domains of life
Trends Biochem Sci. 2023 Sep 15:S0968-0004(23)00212-8. doi: 10.1016/j.tibs.2023.08.009. Online ahead of print.ABSTRACTStructural and evolutionary studies of cyanobacterial phage shock protein A (PspA) and inner membrane-associated protein of 30 kDa (IM30) have revealed that these proteins belong to the endosomal sorting complex required for transport-III (ESCRT-III) superfamily, which is conserved across all three domains of life. PspA and IM30 share secondary and tertiary structures with eukaryotic ESCRT-III proteins, whilst also oligomerizing via conserved interactions. Here, we examine the structures of bacterial ESCRT-...
Source: Trends in Biochemical Sciences - September 17, 2023 Category: Biochemistry Authors: Lukas Schl össer Carsten Sachse Harry H Low Dirk Schneider Source Type: research
Conserved structures of ESCRT-III superfamily members across domains of life
Trends Biochem Sci. 2023 Sep 15:S0968-0004(23)00212-8. doi: 10.1016/j.tibs.2023.08.009. Online ahead of print.ABSTRACTStructural and evolutionary studies of cyanobacterial phage shock protein A (PspA) and inner membrane-associated protein of 30 kDa (IM30) have revealed that these proteins belong to the endosomal sorting complex required for transport-III (ESCRT-III) superfamily, which is conserved across all three domains of life. PspA and IM30 share secondary and tertiary structures with eukaryotic ESCRT-III proteins, whilst also oligomerizing via conserved interactions. Here, we examine the structures of bacterial ESCRT-...
Source: Trends in Biochemical Sciences - September 17, 2023 Category: Biochemistry Authors: Lukas Schl össer Carsten Sachse Harry H Low Dirk Schneider Source Type: research
Conserved structures of ESCRT-III superfamily members across domains of life
Trends Biochem Sci. 2023 Sep 15:S0968-0004(23)00212-8. doi: 10.1016/j.tibs.2023.08.009. Online ahead of print.ABSTRACTStructural and evolutionary studies of cyanobacterial phage shock protein A (PspA) and inner membrane-associated protein of 30 kDa (IM30) have revealed that these proteins belong to the endosomal sorting complex required for transport-III (ESCRT-III) superfamily, which is conserved across all three domains of life. PspA and IM30 share secondary and tertiary structures with eukaryotic ESCRT-III proteins, whilst also oligomerizing via conserved interactions. Here, we examine the structures of bacterial ESCRT-...
Source: Trends in Biochemical Sciences - September 17, 2023 Category: Biochemistry Authors: Lukas Schl össer Carsten Sachse Harry H Low Dirk Schneider Source Type: research
Conserved structures of ESCRT-III superfamily members across domains of life
Trends Biochem Sci. 2023 Sep 15:S0968-0004(23)00212-8. doi: 10.1016/j.tibs.2023.08.009. Online ahead of print.ABSTRACTStructural and evolutionary studies of cyanobacterial phage shock protein A (PspA) and inner membrane-associated protein of 30 kDa (IM30) have revealed that these proteins belong to the endosomal sorting complex required for transport-III (ESCRT-III) superfamily, which is conserved across all three domains of life. PspA and IM30 share secondary and tertiary structures with eukaryotic ESCRT-III proteins, whilst also oligomerizing via conserved interactions. Here, we examine the structures of bacterial ESCRT-...
Source: Trends in Biochemical Sciences - September 17, 2023 Category: Biochemistry Authors: Lukas Schl össer Carsten Sachse Harry H Low Dirk Schneider Source Type: research
Conserved structures of ESCRT-III superfamily members across domains of life
Trends Biochem Sci. 2023 Sep 15:S0968-0004(23)00212-8. doi: 10.1016/j.tibs.2023.08.009. Online ahead of print.ABSTRACTStructural and evolutionary studies of cyanobacterial phage shock protein A (PspA) and inner membrane-associated protein of 30 kDa (IM30) have revealed that these proteins belong to the endosomal sorting complex required for transport-III (ESCRT-III) superfamily, which is conserved across all three domains of life. PspA and IM30 share secondary and tertiary structures with eukaryotic ESCRT-III proteins, whilst also oligomerizing via conserved interactions. Here, we examine the structures of bacterial ESCRT-...
Source: Trends in Biochemical Sciences - September 17, 2023 Category: Biochemistry Authors: Lukas Schl össer Carsten Sachse Harry H Low Dirk Schneider Source Type: research
Conserved structures of ESCRT-III superfamily members across domains of life
Trends Biochem Sci. 2023 Sep 15:S0968-0004(23)00212-8. doi: 10.1016/j.tibs.2023.08.009. Online ahead of print.ABSTRACTStructural and evolutionary studies of cyanobacterial phage shock protein A (PspA) and inner membrane-associated protein of 30 kDa (IM30) have revealed that these proteins belong to the endosomal sorting complex required for transport-III (ESCRT-III) superfamily, which is conserved across all three domains of life. PspA and IM30 share secondary and tertiary structures with eukaryotic ESCRT-III proteins, whilst also oligomerizing via conserved interactions. Here, we examine the structures of bacterial ESCRT-...
Source: Trends in Biochemical Sciences - September 17, 2023 Category: Biochemistry Authors: Lukas Schl össer Carsten Sachse Harry H Low Dirk Schneider Source Type: research
Conserved structures of ESCRT-III superfamily members across domains of life
Trends Biochem Sci. 2023 Sep 15:S0968-0004(23)00212-8. doi: 10.1016/j.tibs.2023.08.009. Online ahead of print.ABSTRACTStructural and evolutionary studies of cyanobacterial phage shock protein A (PspA) and inner membrane-associated protein of 30 kDa (IM30) have revealed that these proteins belong to the endosomal sorting complex required for transport-III (ESCRT-III) superfamily, which is conserved across all three domains of life. PspA and IM30 share secondary and tertiary structures with eukaryotic ESCRT-III proteins, whilst also oligomerizing via conserved interactions. Here, we examine the structures of bacterial ESCRT-...
Source: Trends in Biochemical Sciences - September 17, 2023 Category: Biochemistry Authors: Lukas Schl össer Carsten Sachse Harry H Low Dirk Schneider Source Type: research
Conserved structures of ESCRT-III superfamily members across domains of life
Trends Biochem Sci. 2023 Sep 15:S0968-0004(23)00212-8. doi: 10.1016/j.tibs.2023.08.009. Online ahead of print.ABSTRACTStructural and evolutionary studies of cyanobacterial phage shock protein A (PspA) and inner membrane-associated protein of 30 kDa (IM30) have revealed that these proteins belong to the endosomal sorting complex required for transport-III (ESCRT-III) superfamily, which is conserved across all three domains of life. PspA and IM30 share secondary and tertiary structures with eukaryotic ESCRT-III proteins, whilst also oligomerizing via conserved interactions. Here, we examine the structures of bacterial ESCRT-...
Source: Trends in Biochemical Sciences - September 17, 2023 Category: Biochemistry Authors: Lukas Schl össer Carsten Sachse Harry H Low Dirk Schneider Source Type: research
Conserved structures of ESCRT-III superfamily members across domains of life
Trends Biochem Sci. 2023 Sep 15:S0968-0004(23)00212-8. doi: 10.1016/j.tibs.2023.08.009. Online ahead of print.ABSTRACTStructural and evolutionary studies of cyanobacterial phage shock protein A (PspA) and inner membrane-associated protein of 30 kDa (IM30) have revealed that these proteins belong to the endosomal sorting complex required for transport-III (ESCRT-III) superfamily, which is conserved across all three domains of life. PspA and IM30 share secondary and tertiary structures with eukaryotic ESCRT-III proteins, whilst also oligomerizing via conserved interactions. Here, we examine the structures of bacterial ESCRT-...
Source: Trends in Biochemical Sciences - September 17, 2023 Category: Biochemistry Authors: Lukas Schl össer Carsten Sachse Harry H Low Dirk Schneider Source Type: research
A physicochemical perspective on cellular ageing
Trends Biochem Sci. 2023 Sep 14:S0968-0004(23)00210-4. doi: 10.1016/j.tibs.2023.08.007. Online ahead of print.ABSTRACTCellular ageing described at the molecular level is a multifactorial process that leads to a spectrum of ageing trajectories. There has been recent discussion about whether a decline in physicochemical homeostasis causes aberrant phase transitions, which are a driver of ageing. Indeed, the function of all biological macromolecules, regardless of their participation in biomolecular condensates, depends on parameters such as pH, crowding, and redox state. We expand on the physicochemical homeostasis hypothesi...
Source: Trends in Biochemical Sciences - September 16, 2023 Category: Biochemistry Authors: Sara N Mouton Arnold J Boersma Liesbeth M Veenhoff Source Type: research
Reframing the relationship between motherhood and academic science
Trends Biochem Sci. 2023 Sep 14:S0968-0004(23)00211-6. doi: 10.1016/j.tibs.2023.08.008. Online ahead of print.NO ABSTRACTPMID:37716871 | DOI:10.1016/j.tibs.2023.08.008 (Source: Trends in Biochemical Sciences)
Source: Trends in Biochemical Sciences - September 16, 2023 Category: Biochemistry Authors: Christine E Schaner Tooley Source Type: research
Integrating lipids into figures
Trends Biochem Sci. 2023 Oct;48(10):829-831. doi: 10.1016/j.tibs.2023.07.004.NO ABSTRACTPMID:37714138 | DOI:10.1016/j.tibs.2023.07.004 (Source: Trends in Biochemical Sciences)
Source: Trends in Biochemical Sciences - September 15, 2023 Category: Biochemistry Authors: Xinyu Li Ye Tian Xiaochun Li Sarah R Barger Source Type: research
