Microbial gatekeepers: unraveling the role of the gut microbiota enzyme DPP4 in diabetes management

Trends Biochem Sci. 2023 Sep 26:S0968-0004(23)00231-1. doi: 10.1016/j.tibs.2023.09.005. Online ahead of print.ABSTRACTWang et al. identified dipeptidyl peptidase 4 (DPP4) as a gut microbe-derived enzyme that impacts on host glucose metabolism. They further introduced a novel therapeutic, daurisoline-d4 (Dau-d4), a selective microbial DPP4 (mDPP4) inhibitor that shows promise in improving glucose tolerance, highlighting the potential of therapies that target both host enzymes and gut microbial enzymes.PMID:37770288 | DOI:10.1016/j.tibs.2023.09.005
Source: Trends in Biochemical Sciences - Category: Biochemistry Authors: Source Type: research