Promoting a MOSAIC future in science
Trends Biochem Sci. 2024 Mar 20:S0968-0004(24)00053-7. doi: 10.1016/j.tibs.2024.03.001. Online ahead of print.ABSTRACTDiscoveries at the frontiers of science and finding solutions to pressing biomedical problems will be accelerated when talent, which is widely distributed, is better aligned with opportunities. Strategies to enhance a MOSAIC (Maximizing Opportunities for Scientific and Academic Independent Careers) professoriate and diversify the biomedical landscape are discussed.PMID:38514275 | DOI:10.1016/j.tibs.2024.03.001 (Source: Trends in Biochemical Sciences)
Source: Trends in Biochemical Sciences - March 21, 2024 Category: Biochemistry Authors: Ruma Banerjee Kirsten F Block Source Type: research
Dilation of ion selectivity filters in cation channels
Trends Biochem Sci. 2024 Mar 20:S0968-0004(24)00049-5. doi: 10.1016/j.tibs.2024.02.004. Online ahead of print.ABSTRACTIon channels establish the voltage gradient across cellular membranes by providing aqueous pathways for ions to selectively diffuse down their concentration gradients. The selectivity of any given channel for its favored ions has conventionally been viewed as a stable property, and in many cation channels, it is determined by an ion-selectivity filter within the external end of the ion-permeation pathway. In several instances, including voltage-activated K+ (Kv) channels, ATP-activated P2X receptor channels...
Source: Trends in Biochemical Sciences - March 21, 2024 Category: Biochemistry Authors: Kate Huffer Xiao-Feng Tan Ana I Fern ández-Mariño Surbhi Dhingra Kenton J Swartz Source Type: research
Macromolecular crowding sensing during osmotic stress in plants
Trends Biochem Sci. 2024 Mar 20:S0968-0004(24)00038-0. doi: 10.1016/j.tibs.2024.02.002. Online ahead of print.ABSTRACTOsmotic stress conditions occur at multiple stages of plant life. Changes in water availability caused by osmotic stress induce alterations in the mechanical properties of the plasma membrane, its interaction with the cell wall, and the concentration of macromolecules in the cytoplasm. We summarize the reported players involved in the sensing mechanisms of osmotic stress in plants. We discuss how changes in macromolecular crowding are perceived intracellularly by intrinsically disordered regions (IDRs) in p...
Source: Trends in Biochemical Sciences - March 21, 2024 Category: Biochemistry Authors: G I Meneses-Reyes D L Rodriguez-Bustos C L Cuevas-Velazquez Source Type: research
Promoting a MOSAIC future in science
Trends Biochem Sci. 2024 Mar 20:S0968-0004(24)00053-7. doi: 10.1016/j.tibs.2024.03.001. Online ahead of print.ABSTRACTDiscoveries at the frontiers of science and finding solutions to pressing biomedical problems will be accelerated when talent, which is widely distributed, is better aligned with opportunities. Strategies to enhance a MOSAIC (Maximizing Opportunities for Scientific and Academic Independent Careers) professoriate and diversify the biomedical landscape are discussed.PMID:38514275 | DOI:10.1016/j.tibs.2024.03.001 (Source: Trends in Biochemical Sciences)
Source: Trends in Biochemical Sciences - March 21, 2024 Category: Biochemistry Authors: Ruma Banerjee Kirsten F Block Source Type: research
Dilation of ion selectivity filters in cation channels
Trends Biochem Sci. 2024 Mar 20:S0968-0004(24)00049-5. doi: 10.1016/j.tibs.2024.02.004. Online ahead of print.ABSTRACTIon channels establish the voltage gradient across cellular membranes by providing aqueous pathways for ions to selectively diffuse down their concentration gradients. The selectivity of any given channel for its favored ions has conventionally been viewed as a stable property, and in many cation channels, it is determined by an ion-selectivity filter within the external end of the ion-permeation pathway. In several instances, including voltage-activated K+ (Kv) channels, ATP-activated P2X receptor channels...
Source: Trends in Biochemical Sciences - March 21, 2024 Category: Biochemistry Authors: Kate Huffer Xiao-Feng Tan Ana I Fern ández-Mariño Surbhi Dhingra Kenton J Swartz Source Type: research
Macromolecular crowding sensing during osmotic stress in plants
Trends Biochem Sci. 2024 Mar 20:S0968-0004(24)00038-0. doi: 10.1016/j.tibs.2024.02.002. Online ahead of print.ABSTRACTOsmotic stress conditions occur at multiple stages of plant life. Changes in water availability caused by osmotic stress induce alterations in the mechanical properties of the plasma membrane, its interaction with the cell wall, and the concentration of macromolecules in the cytoplasm. We summarize the reported players involved in the sensing mechanisms of osmotic stress in plants. We discuss how changes in macromolecular crowding are perceived intracellularly by intrinsically disordered regions (IDRs) in p...
Source: Trends in Biochemical Sciences - March 21, 2024 Category: Biochemistry Authors: G I Meneses-Reyes D L Rodriguez-Bustos C L Cuevas-Velazquez Source Type: research
Promoting a MOSAIC future in science
Trends Biochem Sci. 2024 Mar 20:S0968-0004(24)00053-7. doi: 10.1016/j.tibs.2024.03.001. Online ahead of print.ABSTRACTDiscoveries at the frontiers of science and finding solutions to pressing biomedical problems will be accelerated when talent, which is widely distributed, is better aligned with opportunities. Strategies to enhance a MOSAIC (Maximizing Opportunities for Scientific and Academic Independent Careers) professoriate and diversify the biomedical landscape are discussed.PMID:38514275 | DOI:10.1016/j.tibs.2024.03.001 (Source: Trends in Biochemical Sciences)
Source: Trends in Biochemical Sciences - March 21, 2024 Category: Biochemistry Authors: Ruma Banerjee Kirsten F Block Source Type: research
Protein-membrane interactions: sensing and generating curvature
Trends Biochem Sci. 2024 Mar 19:S0968-0004(24)00050-1. doi: 10.1016/j.tibs.2024.02.005. Online ahead of print.ABSTRACTBiological membranes are integral cellular structures that can be curved into various geometries. These curved structures are abundant in cells as they are essential for various physiological processes. However, curved membranes are inherently unstable, especially on nanometer length scales. To stabilize curved membranes, cells can utilize proteins that sense and generate membrane curvature. In this review, we summarize recent research that has advanced our understanding of interactions between proteins and...
Source: Trends in Biochemical Sciences - March 20, 2024 Category: Biochemistry Authors: David H Johnson Orianna H Kou Nicoletta Bouzos Wade F Zeno Source Type: research
Protein-membrane interactions: sensing and generating curvature
Trends Biochem Sci. 2024 Mar 19:S0968-0004(24)00050-1. doi: 10.1016/j.tibs.2024.02.005. Online ahead of print.ABSTRACTBiological membranes are integral cellular structures that can be curved into various geometries. These curved structures are abundant in cells as they are essential for various physiological processes. However, curved membranes are inherently unstable, especially on nanometer length scales. To stabilize curved membranes, cells can utilize proteins that sense and generate membrane curvature. In this review, we summarize recent research that has advanced our understanding of interactions between proteins and...
Source: Trends in Biochemical Sciences - March 20, 2024 Category: Biochemistry Authors: David H Johnson Orianna H Kou Nicoletta Bouzos Wade F Zeno Source Type: research
Mitotic bookmarking by transcription factors: be aware of redundancy
Trends Biochem Sci. 2024 Mar 18:S0968-0004(24)00064-1. doi: 10.1016/j.tibs.2024.03.003. Online ahead of print.ABSTRACTA recent report by Chervova, Molliex, et al. shows redundant functions for the transcription factors (TFs) ESRRB and NR5A2 as mitotic bookmarkers in mouse embryonic stem (ES) cells. These occupy some of their target sites in mitotic chromatin, ensuring their robust reactivation after cell division, including markers and regulators of pluripotency.PMID:38503673 | DOI:10.1016/j.tibs.2024.03.003 (Source: Trends in Biochemical Sciences)
Source: Trends in Biochemical Sciences - March 19, 2024 Category: Biochemistry Authors: Miguel V Silva Diogo S Castro Source Type: research
The RNA tether model for human chromosomal translocation fragile zones
Trends Biochem Sci. 2024 Mar 14:S0968-0004(24)00039-2. doi: 10.1016/j.tibs.2024.02.003. Online ahead of print.ABSTRACTOne of the two chromosomal breakage events in recurring translocations in B cell neoplasms is often due to the recombination-activating gene complex (RAG complex) releasing DNA ends before end joining. The other break occurs in a fragile zone of 20-600 bp in a non-antigen receptor gene locus, with a more complex and intriguing set of mechanistic factors underlying such narrow fragile zones. These factors include activation-induced deaminase (AID), which acts only at regions of single-stranded DNA (ssDNA). R...
Source: Trends in Biochemical Sciences - March 15, 2024 Category: Biochemistry Authors: Di Liu Chih-Lin Hsieh Michael R Lieber Source Type: research
The RNA tether model for human chromosomal translocation fragile zones
Trends Biochem Sci. 2024 Mar 14:S0968-0004(24)00039-2. doi: 10.1016/j.tibs.2024.02.003. Online ahead of print.ABSTRACTOne of the two chromosomal breakage events in recurring translocations in B cell neoplasms is often due to the recombination-activating gene complex (RAG complex) releasing DNA ends before end joining. The other break occurs in a fragile zone of 20-600 bp in a non-antigen receptor gene locus, with a more complex and intriguing set of mechanistic factors underlying such narrow fragile zones. These factors include activation-induced deaminase (AID), which acts only at regions of single-stranded DNA (ssDNA). R...
Source: Trends in Biochemical Sciences - March 15, 2024 Category: Biochemistry Authors: Di Liu Chih-Lin Hsieh Michael R Lieber Source Type: research
The RNA tether model for human chromosomal translocation fragile zones
Trends Biochem Sci. 2024 Mar 14:S0968-0004(24)00039-2. doi: 10.1016/j.tibs.2024.02.003. Online ahead of print.ABSTRACTOne of the two chromosomal breakage events in recurring translocations in B cell neoplasms is often due to the recombination-activating gene complex (RAG complex) releasing DNA ends before end joining. The other break occurs in a fragile zone of 20-600 bp in a non-antigen receptor gene locus, with a more complex and intriguing set of mechanistic factors underlying such narrow fragile zones. These factors include activation-induced deaminase (AID), which acts only at regions of single-stranded DNA (ssDNA). R...
Source: Trends in Biochemical Sciences - March 15, 2024 Category: Biochemistry Authors: Di Liu Chih-Lin Hsieh Michael R Lieber Source Type: research
The RNA tether model for human chromosomal translocation fragile zones
Trends Biochem Sci. 2024 Mar 14:S0968-0004(24)00039-2. doi: 10.1016/j.tibs.2024.02.003. Online ahead of print.ABSTRACTOne of the two chromosomal breakage events in recurring translocations in B cell neoplasms is often due to the recombination-activating gene complex (RAG complex) releasing DNA ends before end joining. The other break occurs in a fragile zone of 20-600 bp in a non-antigen receptor gene locus, with a more complex and intriguing set of mechanistic factors underlying such narrow fragile zones. These factors include activation-induced deaminase (AID), which acts only at regions of single-stranded DNA (ssDNA). R...
Source: Trends in Biochemical Sciences - March 15, 2024 Category: Biochemistry Authors: Di Liu Chih-Lin Hsieh Michael R Lieber Source Type: research
Keeping neuronal activity in check: a novel role for α-synuclein serine-129 phosphorylation in the healthy brain
Trends Biochem Sci. 2024 Mar 6:S0968-0004(24)00051-3. doi: 10.1016/j.tibs.2024.02.006. Online ahead of print.ABSTRACTPhosphorylation of α-synuclein protein at serine-129 (Ser129P) is a widely used marker for disease pathology in neurodegenerative disorders termed synucleinopathies. In groundbreaking work by Parra-Rivas, Madhivanan et al., Ser129P was shown to facilitate the normal function of α-synuclein, bearing significant implications for the transition from a physiological to pathological state.PMID:38453543 | DOI:10.1016/j.tibs.2024.02.006 (Source: Trends in Biochemical Sciences)
Source: Trends in Biochemical Sciences - March 7, 2024 Category: Biochemistry Authors: Danielle E Mor Source Type: research
