Mitotic bookmarking by transcription factors: be aware of redundancy

Trends Biochem Sci. 2024 Mar 18:S0968-0004(24)00064-1. doi: 10.1016/j.tibs.2024.03.003. Online ahead of print.ABSTRACTA recent report by Chervova, Molliex, et al. shows redundant functions for the transcription factors (TFs) ESRRB and NR5A2 as mitotic bookmarkers in mouse embryonic stem (ES) cells. These occupy some of their target sites in mitotic chromatin, ensuring their robust reactivation after cell division, including markers and regulators of pluripotency.PMID:38503673 | DOI:10.1016/j.tibs.2024.03.003

Source: Trends in Biochemical Sciences - March 19, 2024 Category: Biochemistry Authors: Miguel V Silva Diogo S Castro Source Type: research