Transcription and replication: walking a genomic tightrope hand-in-hand

Trends Biochem Sci. 2023 Sep 27:S0968-0004(23)00248-7. doi: 10.1016/j.tibs.2023.09.007. Online ahead of print.ABSTRACTA recent study by Fenstermaker et al. in Nature describes how transcriptionally active RNA polymerase II (Pol II) clings to the genomic tightrope during the passage of the replication fork and rapidly resumes transcription of immature RNA from both strands of nascent DNA, facilitated by protein-protein interactions between the replication and transcription machineries.PMID:37775422 | DOI:10.1016/j.tibs.2023.09.007

Source: Trends in Biochemical Sciences - September 29, 2023 Category: Biochemistry Authors: George Yakoub Martijn S Luijsterburg Source Type: research