Confluence and convergence of Dscam and Pcdh cell-recognition codes

Trends Biochem Sci. 2023 Oct 13:S0968-0004(23)00227-X. doi: 10.1016/j.tibs.2023.09.001. Online ahead of print.ABSTRACTThe ability of neurites of the same neuron to avoid each other (self-avoidance) is a conserved feature in both invertebrates and vertebrates. The key to self-avoidance is the generation of a unique subset of cell-surface proteins in individual neurons engaging in isoform-specific homophilic interactions that drive neurite repulsion rather than adhesion. Among these cell-surface proteins are fly Dscam1 and vertebrate clustered protocadherins (cPcdhs), as well as the recently characterized shortened Dscam (sDscam) in the Chelicerata. Herein, we review recent advances in our understanding of how cPcdh, Dscam, and sDscam cell-surface recognition codes are expressed and translated into cellular functions essential for neural wiring.PMID:37839971 | DOI:10.1016/j.tibs.2023.09.001
Source: Trends in Biochemical Sciences - Category: Biochemistry Authors: Source Type: research