Unlocking the biosynthesis of psychedelic-inspired indolethylamines

Trends Biochem Sci. 2023 Dec 29:S0968-0004(23)00313-4. doi: 10.1016/j.tibs.2023.12.009. Online ahead of print.ABSTRACTA recent report by Chen et al. describes the discovery of RmNMT, a highly active and promiscuous tryptamine N-methyltransferase from the cane toad, Rhinella marina. N,N-dimethyltryptamine derivatives produced by this enzyme were then evaluated for their potential to serve as next-generation treatments for mental health disorders.PMID:38160063 | DOI:10.1016/j.tibs.2023.12.009

Source: Trends in Biochemical Sciences - December 30, 2023 Category: Biochemistry Authors: Abhishek K Sen J Andrew Jones Source Type: research