Revealing eEF-2 kinase: recent structural insights into function

We describe recent structural insights into this unique activation process and examine the effects of specific regulatory signals on this mechanism. We also highlight key unanswered questions to guide future structure-function studies. These include structural mechanisms which enable eEF-2K to interact with upstream/downstream partners and facilitate its integration of diverse inputs, including Ca2+ transients, phosphorylation mediated by energy/nutrient-sensing pathways, pH changes, and metabolites. Answering these questions is key to establishing how eEF-2K harmonizes translation with cellular requirements within the boundaries of its molecular landscape.PMID:38103971 | DOI:10.1016/j.tibs.2023.11.004
Source: Trends in Biochemical Sciences - Category: Biochemistry Authors: Source Type: research