Structural insights into membrane adenylyl cyclases, initiators of cAMP signaling

Trends Biochem Sci. 2023 Dec 28:S0968-0004(23)00297-9. doi: 10.1016/j.tibs.2023.12.002. Online ahead of print.ABSTRACTMembrane adenylyl cyclases (ACs) catalyze the conversion of ATP to the ubiquitous second messenger cAMP. As effector proteins of G protein-coupled receptors and other signaling pathways, ACs receive and amplify signals from the cell surface, translating them into biochemical reactions in the intracellular space and integrating different signaling pathways. Despite their importance in signal transduction and physiology, our knowledge about the structure, function, regulation, and molecular interactions of ACs remains relatively scarce. In this review, we summarize recent advances in our understanding of these membrane enzymes.PMID:38158273 | DOI:10.1016/j.tibs.2023.12.002

Source: Trends in Biochemical Sciences - December 29, 2023 Category: Biochemistry Authors: Dina Schuster Basavraj Khanppnavar Ilayda Kantarci Ved Mehta Volodymyr M Korkhov Source Type: research