Mechanisms of Hydrogen Sulfide against the Progression of Severe Alzheimer ’s Disease in Transgenic Mice at Different Ages
Conclusion: Our findings indicate that appropriate treatments with various sources of H2S, might represent an innovative approach to counteract early and severe AD progression in humans.Pharmacology 2019;103:50 –60 (Source: Pharmacology)
Source: Pharmacology - November 16, 2018 Category: Drugs & Pharmacology Source Type: research
Propranolol Suppresses Cobalt Chloride-Induced Hypoxic Proliferation in Human Umbilical Vein Endothelial Cells in vitro
Conclusions: Propranolol could inhibit CoCl2-induced hypoxic proliferation of HUVECs through inducing apoptosis and cell cycle arrest.Pharmacology 2019;103:61 –67 (Source: Pharmacology)
Source: Pharmacology - November 16, 2018 Category: Drugs & Pharmacology Source Type: research
Multiple-Dose Pharmacokinetics, Pharmacodynamics, and Safety of the Urotensin-II Receptor Antagonist Palosuran in Healthy Male Subjects
Conclusion: Palosuran after multiple-dosing is a well-tolerated drug in healthy subjects, but this finding warrants further investigation in patients.Pharmacology 2018;102:339 –346 (Source: Pharmacology)
Source: Pharmacology - November 1, 2018 Category: Drugs & Pharmacology Source Type: research
Tetanic Facilitation of Neuromuscular Transmission by Adenosine A < sub > 2A < /sub > and Muscarinic M < sub > 1 < /sub > Receptors is Dependent on the Uptake of Choline via High-Affinity Transporters
Conclusion: Data suggest that the recovery of tetanic neuromuscular facilitation by adenosine A2A and M1 receptors is highly dependent on HChT activity and may be weakened in myasthenic patients when HChT is inoperative.Pharmacology 2019;103:38 –49 (Source: Pharmacology)
Source: Pharmacology - October 31, 2018 Category: Drugs & Pharmacology Source Type: research
Comparative Pharmacokinetic Study of Mangiferin in Normal and Alloxan-Induced Diabetic Rats after Oral and Intravenous Administration by UPLC-MS/MS
Conclusions: Compared to normal rats, pharmacokinetic parameters of mangiferin were altered in diabetic condition induced by alloxan. The findings might help to provide useful evidence for modeling of diabetic rats and the clinical applications of mangiferin.Pharmacology 2019;103:30 –37 (Source: Pharmacology)
Source: Pharmacology - October 25, 2018 Category: Drugs & Pharmacology Source Type: research
Malondialdehyde Assay in the Evaluation of Aspirin Antiplatelet Effects
In this study, we compared this MDA assay to the conventional assays in determination of pharmacodynamic aspirin response. For this, aspirin antiplatelet effects were measured in 22 healthy individuals and 63 aspirin treated patients using TX B2 formation enzyme-linked antibody assay, arachidonic acid induced light transmission aggregometry (LTA) and the new fluorometric MDA assay. In patients, MDA levels correlated well with TX formation (R = 0.81; 95% CI 0.69 –0.88;p #x3c; 0.001) and LTA (R = 0.84; CI 0.74 –0.91;p #x3c; 0.001). Receiver operating characteristic analyses revealed that the MDA assay does detect HTPR to...
Source: Pharmacology - October 24, 2018 Category: Drugs & Pharmacology Source Type: research
Prevention of Stent Thrombosis in Rats by a Direct Oral Factor Xa Inhibitor Edoxaban
Conclusion: These results suggest that edoxaban alone and in combination with clopidogrel or aspirin are promising antithrombotic therapies for the prevention of stent thrombosis.Pharmacology 2019;103:17 –22 (Source: Pharmacology)
Source: Pharmacology - October 19, 2018 Category: Drugs & Pharmacology Source Type: research
In vitro and in vivo GABA < sub > A < /sub > Receptor Interaction of the Propanidid Metabolite 4-(2-[Diethylamino]-2-Oxoethoxy)-3-Methoxy-Benzeneacetic Acid
Conclusion: DOMBA modulation of GABAA receptors is associated with sedation in mice. Metabolites of propanidid analogues currently in development may similarly modulate GABAA, and impaired elimination of these metabolites could produce clinically relevant neurophysiologic effects.Pharmacology 2019;103:10 –16 (Source: Pharmacology)
Source: Pharmacology - October 17, 2018 Category: Drugs & Pharmacology Source Type: research
Involvement of MicroRNA-133a in the Protective Effect of Hydrogen Sulfide against Ischemia/Reperfusion-Induced Endoplasmic Reticulum Stress and Cardiomyocyte Apoptosis
Conclusion: These findings suggest the protective effect of miR-133a against I/R-induced ER stress and cardiomyocyte apoptosis and its enhancement of cell motility. Thus, cardioprotection by miR-133a overexpression provides a novel therapeutic approach to the treatment of ischemic heart diseases.Pharmacology 2019;103:1 –9 (Source: Pharmacology)
Source: Pharmacology - October 16, 2018 Category: Drugs & Pharmacology Source Type: research
Antiallodynic Effects of Intrathecal Areca Nut for Spinal Nerve-Ligated and Chemotherapy-Induced Neuropathic Pain in Rats
This study examined the effects of intrathecal areca nut on spinal nerve-ligated and chemotherapy-induced neuropathic pain (NP), and investigated the relevance of spinal 5-hydroxytryptamine (5-HT) and α2-adrenergic receptors to those effects. For drug administration, intrathecal catheters were inserted into the subarachnoid space of male Sprague-Dawley rats. NP was induced either by spinal nerve ligation (left spinal nerves L5 and L6) or by chemotherapeutic injection (intraperitoneal cisplatin, 2 mg/kg/day, once daily for 4 days). Paw withdrawal thresholds (PWT) were mechanically assessed using von Frey filaments. The in...
Source: Pharmacology - October 10, 2018 Category: Drugs & Pharmacology Source Type: research
The Anticancer Effect of Huaier Extract in Renal Cancer 786-O Cells
Conclusion: Huaier plays an anticancer effect partially through the suppression of the PI3K/AKT/mTOR/p70S6K/4E-BP1 pathway and by reversing the EMT process. Huaier may act as an effective agent for treating renal cell carcinoma.Pharmacology 2018;102:316 –323 (Source: Pharmacology)
Source: Pharmacology - October 8, 2018 Category: Drugs & Pharmacology Source Type: research
Structure-Activity Relationship of the GPR55 Antagonist, CID16020046
Conclusion: These data confirm the utility of CID16020046 and ML193 as tools to investigate the physiological role of GPR55, and offer starting points for GPR55 antagonists with optimised pharmacokinetic or other properties.Pharmacology 2018;102:324 –331 (Source: Pharmacology)
Source: Pharmacology - October 8, 2018 Category: Drugs & Pharmacology Source Type: research
Chronic Stress May Not Be a Factor in the Behavioral Response to Chronic Lithium in ICR Mice
Conclusions: The behavioral effects of Li in this study were not affected by stress. The lack of effects of the stressors themselves on behavior suggests that the application of more intrusive stressors might be needed to further explore the issue.Pharmacology 2018;102:281 –286 (Source: Pharmacology)
Source: Pharmacology - October 5, 2018 Category: Drugs & Pharmacology Source Type: research
Nitrosonifedipine, a Photodegradation Product of Nifedipine, Suppresses Pharmacologically Induced Aortic Aneurysm Formation
Conclusion: NO-NIF has the potential to be a new, nifedipine-derived therapeutic drug for suppressing aortic aneurysm formation by directly improving aortic structure with its strong ability to reduce oxidative stress and inflammation.Pharmacology 2018;102:287 –299 (Source: Pharmacology)
Source: Pharmacology - October 5, 2018 Category: Drugs & Pharmacology Source Type: research
Attenuation of Remifentanil-Induced Hyperalgesia by Betulinic Acid Associates with Inhibiting Oxidative Stress and Inflammation in Spinal Dorsal Horn
Remifentanil-induced hyperalgesia (RIH) is known to be associated with oxidative stress and inflammation. Betulinic acid (BA) was reported to reduce visceral pain owing to its anti-oxidative and anti-inflammatory potential. Here, we explored whether BA can attenuate RIH through inhibiting oxidative stress and inflammation in spinal dorsal horn. Sprague-Dawley rats were randomly divided into 4 groups: Control, Incision, RIH, and RIH pre-treated with BA. After pretreated with BA (25 mg/kg, i.g.) for 7 days, rats were subcutaneo usly infused with remifentanil (40 μg/kg) for 30 min during right plantar incision surgery to i...
Source: Pharmacology - October 5, 2018 Category: Drugs & Pharmacology Source Type: research
