A Comparison of Calcium Aggregation and Ultracentrifugation Methods for the Preparation of Rat Brain Microsomes for Drug Metabolism Studies
In conclusion, when an ultracentrifuge is available, preparation of brain microsomes by the ultracentrifugation method might be preferable. However, the calcium aggregation method at a calcium chloride concentration of 10 mM is an acceptable alternative to the ultracentrifuge method.Pharmacology (Source: Pharmacology)
Source: Pharmacology - October 18, 2021 Category: Drugs & Pharmacology Source Type: research
Erratum
Pharmacology (Source: Pharmacology)
Source: Pharmacology - October 15, 2021 Category: Drugs & Pharmacology Source Type: research
Physical and Chemical Compatibility of Etomidate and Propofol Injectable Emulsions
Conclusions: These results demonstrate that etomidate emulsion is physically and chemically compatible with propofol emulsions up to 24 h at 4 °C, 25°C, and 37°C, suggesting that etomidate and propofol can be administrated in mixture without adversely affecting product characteristics, at least in vitro.Pharmacology (Source: Pharmacology)
Source: Pharmacology - October 13, 2021 Category: Drugs & Pharmacology Source Type: research
Downregulation of p38 MAPK Activation and Radiation-Sensitive 52 Expression Enhances 5-Fluorouracil and Erlotinib-Induced Cytotoxicity in Human Lung Squamous Cells
Conclusion: The results provide a rationale for combining 5-FU and erlotinib in lung cancer treatment.Pharmacology (Source: Pharmacology)
Source: Pharmacology - September 30, 2021 Category: Drugs & Pharmacology Source Type: research
The Inhibitory Effect of Wood Creosote on the Movement of < b > < i > Anisakis < /i > < /b > Larvae: An Implication for the Treatment of Acute Anisakiasis
Conclusion: Our results suggest the potential usefulness of the medicine containing wood creosote in the treatment of acuteAnisakis infection of the gastrointestinal tract.Pharmacology (Source: Pharmacology)
Source: Pharmacology - September 17, 2021 Category: Drugs & Pharmacology Source Type: research
Inhaled Budesonide vis- à-vis Inhaled Mometasone in Chinese Children with Mild Persistent Asthma: A Single-Center, Retrospective Study
Conclusions: Although both drugs showed improvement in the quality of life of asthmatic children with manageable treatment-emergent adverse effects, the improvement was augmented in MF-treated children.Level of Evidence: The level of evidence was III.Technical Efficacy Stage: The technical efficacy stage was 4.Pharmacology (Source: Pharmacology)
Source: Pharmacology - September 9, 2021 Category: Drugs & Pharmacology Source Type: research
Activation of SIRT1 by Resveratrol Alleviates Pressure Overload-Induced Cardiac Hypertrophy via Suppression of TGF- β1 Signaling
Conclusions: Taken together, these results indicated that activation of SIRT1 by Rsv attenuates cardiac hypertrophy, cardiac fibrosis, and improves cardiac function possibly via regulation of the TGF- β1/p-Smad3 signaling pathway. Our study may provide a potential therapeutic strategy for cardiac hypertrophy.Pharmacology (Source: Pharmacology)
Source: Pharmacology - September 8, 2021 Category: Drugs & Pharmacology Source Type: research
Canagliflozin Improves Liver Function in Rats by Upregulating Asparagine Synthetase
Conclusion: CANA significantly alleviated liver injury by activating the AMPK/Nrf2/ATF4 axis and upregulating ASNS expression, indicating its potential for treating patients with type 2 diabetes mellitus with impaired liver function.Pharmacology (Source: Pharmacology)
Source: Pharmacology - September 7, 2021 Category: Drugs & Pharmacology Source Type: research
Long Noncoding RNA TTC39A-AS1 Promotes Breast Cancer Tumorigenicity by Sponging MicroRNA-483-3p and Thereby Upregulating MTA2
Conclusion: The newly identified TTC39A-AS1/miR-483-3p/MTA2 pathway was revealed to be a critical regulator in the tumorigenicity of BC, possibly offering a novel therapeutic direction for the anticancer treatment of BC.Pharmacology (Source: Pharmacology)
Source: Pharmacology - September 6, 2021 Category: Drugs & Pharmacology Source Type: research
Neurokinin-1 Antagonism Distinguishes the Role of Norepinephrine Transporter from Dopamine Transporter in Mediating Amphetamine Behaviors
Conclusions: The results from the current study demonstrate that aprepitant attenuates the expression of AMPH-induced CPP in DAT-KO mice but not in NET-KO mice suggesting a role for NK1R-mediated NET regulation in AMPH-induced behaviors.Pharmacology (Source: Pharmacology)
Source: Pharmacology - September 2, 2021 Category: Drugs & Pharmacology Source Type: research
Apatinib Inhibits Angiogenesis in Intrahepatic Cholangiocarcinoma by Regulating the Vascular Endothelial Growth Factor Receptor-2/Signal Transducer and Activator of Transcription Factor 3/Hypoxia Inducible Factor 1 Subunit Alpha Signaling Axis
Conclusions: Based on the above findings, we conclude that apatinib inhibits HuCCT-1 and RBE cell proliferation, migration, and tumor angiogenesis by inhibiting the VEGFR2/STAT3/HIF-1 α axis signaling pathway. Apatinib can be a promising drug for ICC-targeted molecular therapy.Pharmacology (Source: Pharmacology)
Source: Pharmacology - August 19, 2021 Category: Drugs & Pharmacology Source Type: research
Remdesivir: A Closer Look at Its Effect in COVID-19 Pandemic
Background: The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the etiology of COVID-19 pandemic, resulted in significant harm to the affected countries in every aspect of life. The virus infected over 139 million patients and resulted in over 2.9 million deaths until April 16, 2021. New variants of this virus were identified that spread rapidly worldwide.Summary: Remdesivir, a prodrug of adenosine nucleotide analog, is an antiviral with a broad spectrum of activity that was tested on SARS and Middle East respiratory syndrome infections. In vitro studies conducted on SARS-CoV-2 revealed that remdesivir inhib...
Source: Pharmacology - August 10, 2021 Category: Drugs & Pharmacology Source Type: research
LncRNA XIST Contributes to Cisplatin Resistance of Lung Cancer Cells by Promoting Cellular Glycolysis through Sponging miR-101-3p
Conclusions: This study reveals a new molecular mechanism for the lncRNA-XIST-promoted cisplatin resistance via sponging miR-101-3p, leading to de-repression of cellular glycolysis. Moreover, these findings warrant further in vivo investigations to study XIST as a potential target to overcome cisplatin resistance.Pharmacology (Source: Pharmacology)
Source: Pharmacology - August 5, 2021 Category: Drugs & Pharmacology Source Type: research
Astragalus Polysaccharide Regulates miR-182/Bcl-2 Axis to Relieve Metabolic Memory through Suppressing Mitochondrial Damage-Mediated Apoptosis in Retinal Pigment Epithelial Cells
Conclusion: APS alleviated mitochondrial damage and apoptosis induced by metabolic memory by regulating the miR-182/Bcl-2 axis, which might serve as a new strategy for the treatment of diabetic retinopathy.Pharmacology (Source: Pharmacology)
Source: Pharmacology - August 5, 2021 Category: Drugs & Pharmacology Source Type: research
A Quantitative Systems Pharmacology Framework for Optimal Doxorubicin Granulocyte Colony-Stimulating Factor Regimens in Triple-Negative Breast Cancer
Conclusion: This work suggests future avenues for optimal regimens of chemotherapy with prophylactic G-CSF support. Importantly, the algorithmic approach that we developed can aid in balancing the anticancer and the neutropenic effects of both drugs, and therefore contributes to rational considerations in clinical decision-making in triple-negative breast cancer.Pharmacology (Source: Pharmacology)
Source: Pharmacology - August 4, 2021 Category: Drugs & Pharmacology Source Type: research
