The Activation of Cannabinoid Type-2 Receptor with JWH-133 Protects Uterine Ischemia/Reperfusion-Induced Damage
Conclusion: The results showed that JWH-133 was effective in reducing uterine IR damage. Cannabinoids may be a new alternative that may be used in the transplantation process in the future.Pharmacology (Source: Pharmacology)
Source: Pharmacology - October 26, 2020 Category: Drugs & Pharmacology Source Type: research
LINC00460 Enhances Bladder Carcinoma Cell Proliferation and Migration by Modulating miR-612/FOXK1 Axis
Conclusions: LINC00460 promoted bladder carcinoma progression via sponging miR-162 to facilitate FOXK1 expression, suggesting that LINC00460 might have the potential of being explored as a therapeutic target for treatment of bladder carcinoma.Pharmacology (Source: Pharmacology)
Source: Pharmacology - October 7, 2020 Category: Drugs & Pharmacology Source Type: research
SARS-CoV-2 and the Possible Role of Raf/MEK/ERK Pathway in Viral Survival: Is This a Potential Therapeutic Strategy for COVID-19?
Pharmacology (Source: Pharmacology)
Source: Pharmacology - October 2, 2020 Category: Drugs & Pharmacology Source Type: research
Predictive Value of FMO3 Variants on Plasma Disposition and Adverse Reactions of Oral Voriconazole in Febrile Neutropenia
Conclusion: FMO3 E308G reduces the activity of the FMO3 enzyme by decreasing the metabolic ability of VRC, which increases the plasma concentration of VRC and may also lead to adverse reactions in patients with FN.Pharmacology (Source: Pharmacology)
Source: Pharmacology - September 30, 2020 Category: Drugs & Pharmacology Source Type: research
Effects of Cellular Senescence on Dental Follicle Cells
The dental follicle is part of the tooth germ, and isolated stem cells from this tissue (dental follicle cells; DFCs) are considered, for example, for regenerative medicine and immunotherapies. However somatic stem cells can also improve pharmaceutical research. Cell proliferation is limited by the induction of senescence, which, while reducing the therapeutic potential of DFCs for cell therapy, can also be used to study aging processes at the cellular level that can be used to test anti-aging pharmaceuticals. Unfortunately, very little is known about cellular senescence in DFCs. This review presents current knowledge abou...
Source: Pharmacology - September 25, 2020 Category: Drugs & Pharmacology Source Type: research
Neoadjuvant Chemotherapy in Pancreatic Cancer: An Appraisal of the Current High-Level Evidence
At the time of diagnosis, only about 20% of patients with pancreatic ductal adenocarcinoma (PDAC) have resectable disease. PDAC treatment necessitates a multidisciplinary approach, and adjuvant chemotherapy after upfront resection is an established means of preventing recurrence. Neoadjuvant chemotherapy (NAT), originally introduced to downstage tumor size, is nowadays more frequently used for selection of patients with favorable tumor biology and to control potential micrometastases. While NAT is routinely applied in locally advanced (LA) PDAC, there is increasing evidence demonstrating benefits of NAT in borderline resec...
Source: Pharmacology - September 23, 2020 Category: Drugs & Pharmacology Source Type: research
Marble Burying in NMRI Male Mice Is Preferentially Sensitive to Pre- Versus Postsynaptic 5-HT < sub > 1A < /sub > Receptor Biased Agonists
Obsessive compulsive disorder (OCD) is a psychiatric disorder characterized by excessive and repetitive thoughts and gestures, mainly treated pharmacologically with selective serotonin reuptake inhibitors (SSRIs). The marble burying test in mice is commonly used to model OCD and has been shown to be sensitive to SSRIs, which decrease burying behavior. The activity of SSRIs in this model is mediated through activation of 5-hydroxytryptamine (5-HT)1A receptors, but the respective implication of pre- versus postsynaptic 5-HT1A receptors has not been elucidated. Here, we investigated marble burying behavior by male NMRI mice f...
Source: Pharmacology - September 18, 2020 Category: Drugs & Pharmacology Source Type: research
When Therapeutic IgA Antibodies Might Come of Age
Background: Extensive efforts have been made in optimizing monoclonal immunoglobulin (Ig)G antibodies for use in clinical practice. Accumulating evidence suggests that IgA or anti-Fc αRI could also represent an exciting avenue toward novel therapeutic strategies.Summary: Here, we underline that IgA is more effective in recruiting neutrophils for tumor cell killing and is potently active against several pathogens, including rotavirus, poliovirus, influenza virus, and SARS-CoV-2. IgA could also be used to modulate excessive immune responses in inflammatory diseases. Furthermore, secretory IgA is emerging as a major regulato...
Source: Pharmacology - September 18, 2020 Category: Drugs & Pharmacology Source Type: research
Pharmacokinetics and Safety of Intravenous, Intravesical, Rectal, Transdermal, and Vaginal Melatonin in Healthy Female Volunteers: A Cross-Over Study
Conclusion: Rectally and vaginally administered melatonin may serve as relevant alternatives to standard oral melatonin therapy. Transdermal delivery of melatonin displayed an extended absorption and can be applied if prolonged effects are intended. Intravesical administration displayed, as expected, a very limited bioavailability. Melatonin administered by these routes of administration was safe.Pharmacology (Source: Pharmacology)
Source: Pharmacology - September 16, 2020 Category: Drugs & Pharmacology Source Type: research
Tailored Sublingual Immunotherapy in a Monosensitized Child with Natural Rubber Latex Allergy
Adverse reactions to natural rubber latex (NRL) represent a group of clinical manifestations that include non-allergic reactions and immediate-type or delayed-type allergic reactions. NRL sublingual immunotherapy (SLIT) has been demonstrated to be an effective and safe practice for latex clinical manifestations with good patient tolerance. A pediatric case of NRL allergy managed with an effective tailored SLIT is described. This case is compelling because the girl, who did not have an atopic background, suffered from NRL allergy with high reactivity and unique monosensitization. To the best of our knowledge, this is the fi...
Source: Pharmacology - September 7, 2020 Category: Drugs & Pharmacology Source Type: research
Inflamm-Aging: Arginase-II as Stage Setter in Age-Related Adipose Tissue Inflammation
Pharmacology (Source: Pharmacology)
Source: Pharmacology - September 4, 2020 Category: Drugs & Pharmacology Source Type: research
Attenuation of Cardiac Autonomic Neuropathy by Escin in Diabetic Rats
Cardiac autonomic neuropathy (CAN) is a least diagnosed complication of diabetes. Inflammation and oxidative stress play a crucial role in the pathophysiology of cardiomyopathy and neuropathy. Escin has anti-inflammatory activity and antioxidant activity. Hence, the present study was designed to evaluate the effect of escin in the management of CAN. Diabetes was induced inSprague Dawley rats with streptozotocin (STZ). Diabetic animals were randomized in different groups after 6 weeks. Animals in the diabetic control group received no treatment, while animals in other groups received escin at dose 5, 10, and 20 mg/kg for 4 ...
Source: Pharmacology - September 2, 2020 Category: Drugs & Pharmacology Source Type: research
Prolonged Duration of Erythropoiesis-Stimulating Agents ’ Action Delays Disease Progression in Anti-Thy 1 Antibody-Induced Chronic Glomerulonephritis Rats
Conclusion: Prolonged duration of ESAs ’ action contributed significantly to their renoprotective effects.Pharmacology (Source: Pharmacology)
Source: Pharmacology - August 21, 2020 Category: Drugs & Pharmacology Source Type: research
Protective Effects of Allicin on ISO-Induced Rat Model of Myocardial Infarction via JNK Signaling Pathway
Conclusion: Allicin can reduce oxidative stress damage and cardiomyocyte apoptosis in rat model of myocardial infarction and can significantly regulate JNK signaling pathway.Pharmacology (Source: Pharmacology)
Source: Pharmacology - August 12, 2020 Category: Drugs & Pharmacology Source Type: research
Digest the Sugar, Kill the Parasite: A New Experimental Concept in Treating Alveolar Echinococcosis
Discussion: We raised our hypothesis that this “aborting” effect may be linked to an altered PD1 and IL-10 response fine-tuning between immunopathology and immune protection. These findings justify a continuation of these experiments upon therapeuticalin vivo administration of the enzymes.Pharmacology (Source: Pharmacology)
Source: Pharmacology - July 31, 2020 Category: Drugs & Pharmacology Source Type: research
