Myo-Inositol Potentiates the Inhibitory Effect of Metformin on Prolactin Levels
Discussion: The obtained results suggest that myo-inositol supplementation potentiates the inhibitory effect of metformin on prolactin levels in women with hyperprolactinemia.Pharmacology (Source: Pharmacology)
Source: Pharmacology - February 3, 2023 Category: Drugs & Pharmacology Source Type: research
DPP4 Inhibitor Sitagliptin Reduces Inflammatory Responses and Mast Cell Activation in Allergic Rhinitis
Conclusion: Sitagliptin suppresses the effector phase of AR, and this mechanism is partly attributed to the suppression of inflammatory response and mast cell degranulation.Pharmacology (Source: Pharmacology)
Source: Pharmacology - February 1, 2023 Category: Drugs & Pharmacology Source Type: research
Melatonin Supports the Survival of Cholinergic Neurons in Organotypic Brain Slices of the Basal Nucleus of Meynert
The nucleus basalis of Meynert (nBM) is the major source of cholinergic neurons in the basal forebrain, which require nerve growth factor (NGF) for their survival. Melatonin, a pleiotropic hormone, has been shown to exert neuroprotection in several experimental models, but its effect on nBM neurons is not well known. Thus, the aim of this study is to evaluate the effect of melatonin in organotypic brain slices of the nBM. Organotypic nBM slices were incubated for 2 weeks without (control) or with 100 ng/mL NGF, 1 μM melatonin, or a combination of both. Cholinergic neurons were immunohistochemically stained for choline ace...
Source: Pharmacology - February 1, 2023 Category: Drugs & Pharmacology Source Type: research
Experimental Investigations of Monomethyl and Dimethyl Fumarate in an Astrocyte-Microglia Co-Culture Model of Inflammation
Discussion: In different set-ups of the astrocyte-microglia co-culture model of inflammation, MMF has not shown significant effects. DMF had only limited effects on microglia phenotypes and AQP4 expression. In summary, mechanisms of action of fumarates probably do not involve direct effects on microglia phenotypes as well as Cx43 and AQP4 expression.Pharmacology (Source: Pharmacology)
Source: Pharmacology - February 1, 2023 Category: Drugs & Pharmacology Source Type: research
Modulation of Neutrophil Function by Recombinant Human IgG1 Fc Hexamer in the Endogenous K/BxN Mouse Model of Rheumatoid Arthritis
Conclusion: In the endogenous K/BxN mouse model of rheumatoid arthritis, amelioration can be explained in part by inhibition of neutrophil infiltration into the joints as well as inhibition of IL-1 β production. Given the observed inhibitory properties on neutrophils, rFc-µTP-L309C may be a potential therapeutic candidate to treat autoimmune and inflammatory conditions in which neutrophils are the predominant cell type involved in pathogenesis.Pharmacology (Source: Pharmacology)
Source: Pharmacology - January 25, 2023 Category: Drugs & Pharmacology Source Type: research
Erratum
Pharmacology (Source: Pharmacology)
Source: Pharmacology - January 19, 2023 Category: Drugs & Pharmacology Source Type: research
The Aryl Hydrocarbon Receptor Ligand 6-Formylindolo(3,2-b)carbazole Promotes Estrogen Receptor Alpha and c-Fos Protein Degradation and Inhibits MCF-7 Cell Proliferation and Migration
Conclusions: Activation of AHR results in a decreased MCF-7 cell proliferation and migration by ER α and c-Fos down regulation. Targeting AHR might be a promising therapy for breast cancer treatment, particularly when estrogen-independent ERα reactivation presents.Pharmacology (Source: Pharmacology)
Source: Pharmacology - January 19, 2023 Category: Drugs & Pharmacology Source Type: research
