Luteolin Attenuates Diabetic Myocardial Hypertrophy by Inhibiting Proteasome Activity
Conclusion: This study indicates that luteolin protected against DCM in mice, including T1DM and T2DM, by upregulating phosphorylated protein AMPK and AKT/GSK-3 pathways while decreasing the proteasome activity. These findings suggest that luteolin may be a potential therapeutic agent for DCM.Pharmacology (Source: Pharmacology)
Source: Pharmacology - November 24, 2022 Category: Drugs & Pharmacology Source Type: research
Radioprotective Effect of Zinc Nanoparticles on Ionizing Radiation-induced Nephrotoxicity in Mice
Conclusion: Zn NPs treatment, especially at 25 mg/kg dose, attenuates the side effect of IR on kidneys through reducing oxidative stress factors, biochemical, and histopathological changes.Pharmacology (Source: Pharmacology)
Source: Pharmacology - November 24, 2022 Category: Drugs & Pharmacology Source Type: research
Radioprotective Effect of Zinc Nanoparticles on Ionizing Radiation-Induced Nephrotoxicity in Miceds
Conclusion: Zn NPs treatment, especially at 25 mg/kg dose, attenuates the side effect of IR on kidneys through reducing oxidative stress factors, biochemical, and histopathological changes.Pharmacology (Source: Pharmacology)
Source: Pharmacology - November 24, 2022 Category: Drugs & Pharmacology Source Type: research
LncRNA DDX11-AS1 Promotes Chemoresistance through LIN28A-Mediated ATG12 mRNA Stabilization in Breast Cancer
Conclusion: This study clarifies the role of DDX11-AS1 in breast cancer chemoresistance and revealed a new mechanism, that is, interacting with LIN28A to stabilize ATG7 and ATG12 and jointly promote chemorefractory. These findings warrant further in vivo investigations to study DDX11-AS1 as a potential target to overcome chemoresistance.Pharmacology (Source: Pharmacology)
Source: Pharmacology - November 16, 2022 Category: Drugs & Pharmacology Source Type: research
The Choice between Intravenous and Subcutaneous Immunoglobulins: Aspects for Consideration
Background: Intravenous immunoglobulin and subcutaneous immunoglobulin preparations are used to treat primary and secondary immunodeficiencies, as well as autoimmune and inflammatory conditions.Summary: For certain indications, only defined formulations or routes of administration are approved by health authorities. However, for other diseases, there are more options, and treatment decisions may be based on different aspects, such as patient conditions and preferences, pharmacokinetics, or pharmacoeconomic considerations.Key Messages: Understanding the two different treatment modalities may support the decision-making for ...
Source: Pharmacology - November 8, 2022 Category: Drugs & Pharmacology Source Type: research
Comparative Efficacy and Safety of Biological Agents in the Treatment of Lupus Nephritis: A Network Meta-Analysis
Conclusions: Low-dose IL-2 was the most effective induction treatment for patients with lupus nephritis and had the lowest potential for SAE. Higher complete remission rates and a more favorable safety profile suggest that low-dose IL-2, obinutuzumab, rituximab, and belimumab may be superior to the current control as treatments for lupus nephritis.Pharmacology (Source: Pharmacology)
Source: Pharmacology - November 3, 2022 Category: Drugs & Pharmacology Source Type: research
Effects of Bile Duct Ligation and Ghrelin Treatment on the Colonic Barrier and Microbiome of Mice
Conclusion: Ghrelin treatment did not improve weight loss and liver damage but increased gene expression of colonic TJ proteins and restored the alpha-diversity of the microbiome. Since protective effects of ghrelin might be masked by the severity of the model, we suggest follow-up studies in models of milder CLD.Pharmacology (Source: Pharmacology)
Source: Pharmacology - November 3, 2022 Category: Drugs & Pharmacology Source Type: research
Recapitulating the Pharmacological Interactions of Cetuximab with Sunitinib and Cisplatin in Head and Neck Carcinoma Cells in vitro
Conclusion: Cetuximab regulates the expression and activity of key membrane drug transporters in head and neck cancer cells, involved in drug resistance. The deregulation of the transport mechanism behind cisplatin and sunitinib uptake reverses drug resistance and enhances the cytotoxicity of both drugs.Pharmacology (Source: Pharmacology)
Source: Pharmacology - October 21, 2022 Category: Drugs & Pharmacology Source Type: research
No Evident Prognostic Benefit of Statin Use in Diffuse Large B-Cell Lymphoma Patients with Unfavorable Disease Features Treated with R-DA-EPOCH
Recent reports indicate that patients with aggressive non-Hodgkin lymphomas might benefit if concomitantly receiving statins with rituximab, cyclophosphamide, hydroxydaunorubicin, vincristine (Oncovin) and prednisone immunochemotherapy. We retrospectively analyzed a cohort of 130 newly diagnosed diffuse large B-cell lymphomas with unfavorable clinical features treated with first-line rituximab, dose-adjusted etoposide, prednisone, vincristine [Oncovin], cyclophosphamide, hydroxydaunorubicin (R-DA-EPOCH) immunochemotherapy in period 2005 –2019. A total of 17/130 (13.1%) patients received statins concomitantly with immunoc...
Source: Pharmacology - October 13, 2022 Category: Drugs & Pharmacology Source Type: research
Prognostic Impact of Landiolol in Patients with Acute Heart Failure and Atrial Fibrillation with Rapid Ventricular Rates: A Pilot Observational Study
Conclusion: Patients with ADHF and AF who received landiolol for rate control during the acute phase had better prognoses than those who did not receive landiolol.Pharmacology (Source: Pharmacology)
Source: Pharmacology - October 7, 2022 Category: Drugs & Pharmacology Source Type: research
Effects of Rapamycin on the Expression of Redox Enzymes in Aortic Vascular Smooth Muscle Cells from Marfan Syndrome Mice
In conclusion, this study further characterized the mechanism of action of rapamycin. It provided an insight into how rapamycin interferes with the regulation of redox homeostasis essential for ROS-dependent signaling that does not incur cellular damage.Pharmacology (Source: Pharmacology)
Source: Pharmacology - September 29, 2022 Category: Drugs & Pharmacology Source Type: research
Electrophysiological Safety Profile of Antiestrogenic Therapies in the Isolated Rabbit Heart
Conclusion: The present study shows no acute proarrhythmic effect of tamoxifen and fulvestrant in an established whole heart model when employing clinically relevant concentrations.Pharmacology (Source: Pharmacology)
Source: Pharmacology - September 29, 2022 Category: Drugs & Pharmacology Source Type: research
Erratum
Pharmacology (Source: Pharmacology)
Source: Pharmacology - September 20, 2022 Category: Drugs & Pharmacology Source Type: research
The Safety and Efficacy of Clonidine in Hemodialysis Patients: A Systematic Review and Meta-Analysis
Conclusions: There is no evidence supporting the long-term use of clonidine in the HD population and a significant side-effect profile. There is low-quality evidence demonstrating the efficacy of clonidine in lowering BP in HD patients in short-term use, but significant safety concerns remain. Fluid removal strategies and other antihypertensives should be used over clonidine for long-term BP control in the HD population.Pharmacology (Source: Pharmacology)
Source: Pharmacology - September 8, 2022 Category: Drugs & Pharmacology Source Type: research
Ferric Citrate Hydrate Has Little Impact on Hyperplasia of Enterochromaffin Cells in the Rat Small Intestine Compared to Sodium Ferrous Citrate
Conclusion: The lower impact on the hyperplasia of enterochromaffin cells of FC compared to SF may contribute to the maintenance of rats ’ physical condition.Pharmacology (Source: Pharmacology)
Source: Pharmacology - August 25, 2022 Category: Drugs & Pharmacology Source Type: research
