Genistein Protects H9c2 Cardiomyocytes against Chemical Hypoxia-Induced Injury via Inhibition of Apoptosis
Conclusions: Gen prevents chemical hypoxia-induced cell apoptosis through inhibition of the mitochondrial apoptotic pathway, exerting protective effects on H9c2 cardiomyocytes.Pharmacology 2019;103:282 –290 (Source: Pharmacology)
Source: Pharmacology - February 26, 2019 Category: Drugs & Pharmacology Source Type: research
Design and Discovery of Novel 1,3,5-Triazines as Dipeptidyl Peptidase-4 Inhibitor against Diabetes
This study aims at synthesizing novel di-morpholine 1,3,5-triazine derivatives as antidiabetic agent via inhibition of dipeptidyl peptidase-4 (DPP-4). The molecules were developed via sequential nucleophilic reaction to afford target derivatives 5(a –f) and subsequently tested for inhibitory potency against DPP iso-enzymes, such as DPP-4, DPP-8, and DPP-9. The in vitro inhibition assay suggested that these derivatives prominently and selectively inhibit DPP-4 over DPP-8 and DPP-9. These molecules also showed no presence of cardiotoxicity, a s confirmed by no activity against human Ether-à-go-go related gene channel. T...
Source: Pharmacology - February 21, 2019 Category: Drugs & Pharmacology Source Type: research
Multiple Signal Pathways Involved in Crocetin-Induced Apoptosis in KYSE-150 Cells
Conclusions: These findings suggested that crocetin interfered with multiple signal pathways in KYSE-150 cells. Therefore, this study suggested that crocetin could potentially be used as a therapeutic candidate for the treatment of esophageal cancer.Pharmacology 2019;103:263 –272 (Source: Pharmacology)
Source: Pharmacology - February 15, 2019 Category: Drugs & Pharmacology Source Type: research
Suppression of KCNQ/M Potassium Channel in Dorsal Root Ganglia Neurons Contributes to the Development of Osteoarthritic Pain
Osteoarthritic pain has a strong impact on patients ’ quality of life. Understanding the pathogenic mechanisms underlying osteoarthritic pain will likely lead to the development of more effective treatments. In the present study of osteoarthritic model rats, we observed a reduction of M-current density and a remarkable decrease in the levels of KCN Q2 and KCNQ3 proteins and mRNAs in dorsal root ganglia (DRG) neurons, which were associated with hyperalgesic behaviors. The activation of KCNQ/M channels with flupirtine significantly increased the mechanical threshold and prolonged the withdrawal latency of osteoarthritic mo...
Source: Pharmacology - February 14, 2019 Category: Drugs & Pharmacology Source Type: research
Antifibrotic Agent Pirfenidone Suppresses Proliferation of Human Pancreatic Cancer Cells by Inducing G0/G1 Cell Cycle Arrest
Conclusions: These results demonstrated that the antifibrotic agent PFD might have antiproliferative effects on PCCs by inducing G0/G1 cell cycle arrest. This suggests that PFD may target not only fibroblasts but also PCCs in the tumor microenvironment of pancreatic cancer.Pharmacology 2019;103:250 –256 (Source: Pharmacology)
Source: Pharmacology - February 7, 2019 Category: Drugs & Pharmacology Source Type: research
Probucol Slows the Progression of Cataracts in Streptozotocin-Induced Hyperglycemic Rats
We examined the effect of probucol, an antihyperlipidemic drug with potent antioxidant properties, on cataract formation in streptozotocin (STZ)-induced hyperglycemic rats that were given 5% D-glucose as drinking water. Probucol treatment was initiated immediately after the induction of hyperglycemia was confirmed. Using full horizontal-plane lens images captured with an original digital camera system, the opacity of central region of lens was assessed by measuring the opaque area in the region. Central opacities were detected after 3 weeks of hyperglycemia, and progressed in a time-dependent manner. The majority of STZ-in...
Source: Pharmacology - February 6, 2019 Category: Drugs & Pharmacology Source Type: research
Comparison of Active Substance Losses and Total Weight Losses of Tablets Administered Via Feeding Tube
Conclusion: Drug loss analysis with analytical balance may overestimate ASL, as was proved for EntericCT in this study. ASL were significantly lower when method B was used.Pharmacology 2019;103:246 –249 (Source: Pharmacology)
Source: Pharmacology - February 6, 2019 Category: Drugs & Pharmacology Source Type: research
Iron Chelation as Novel Treatment for Interstitial Cystitis
Interstitial cystitis (IC) is a highly prevalent debilitating disease, with its cardinal symptoms being severe pain, urinary urgency and frequency. The associated pain may eventually lead as a last resort to removal of the bladder. Though the initial trigger for IC remains largely unknown, we propose novel iron chelators as a possible new treatment for this disease. Iron is a mandatory component for the generation of reactive oxygen species (ROS). A substantial decrease in ROS production and thus inflammation can be achieved by effectively sequestering host iron, which we believe may improve outcome and quality of life in ...
Source: Pharmacology - January 31, 2019 Category: Drugs & Pharmacology Source Type: research
Osteoprotective Effect of Cimiracemate in Glucocorticoid-Induced Osteoporosis by Osteoprotegerin/Receptor Activator of Nuclear Factor κ B/Receptor Activator of Nuclear Factor Kappa-Β Ligand Signaling
Conclusion: In conclusion, our study suggests that cimiracemate A protects the glucocorticoid-induced osteoporosis by regulating the RANKL/RANK/OPG signaling pathway.Pharmacology 2019;103:163 –172 (Source: Pharmacology)
Source: Pharmacology - January 31, 2019 Category: Drugs & Pharmacology Source Type: research
Effect of Verapamil on Kidney Function Using Radionuclide Imaging
Conclusion: Verapamil dilates the renal artery and accelerates both the Tmax and T1/2 in the renogram. It increases renal blood perfusion and protects kidney function and therefore improves its work. However, verapamil should not be used while performing renograms to avoid misleading results.Pharmacology 2019;103:173 –178 (Source: Pharmacology)
Source: Pharmacology - January 31, 2019 Category: Drugs & Pharmacology Source Type: research
Impact of Different Pharmacotherapies on Long-Term Outcomes in Patients with Electrical Storm
Conclusion: ACEi/ARB therapy is associated with improved survival and MACE in patients with ES, whereas statins and amiodarone therapy had no impact on long-term prognostic endpoints.Pharmacology 2019;103:179 –188 (Source: Pharmacology)
Source: Pharmacology - January 31, 2019 Category: Drugs & Pharmacology Source Type: research
Evaluation of Antidepressant Effects on Recovery of Electrical Field Stimulation-Induced Contractions that have been Suppressed by Clonidine in Isolated Rat Vas Deferens
Conclusions: These findings suggest that amitriptyline, mirtazapine, and trazodone induce voiding impairment caused by increased urethral resistance by enhancing sympathetic nerve activities attributed to α2-AR antagonism.Pharmacology 2019;103:189 –201 (Source: Pharmacology)
Source: Pharmacology - January 31, 2019 Category: Drugs & Pharmacology Source Type: research
Chronic Addiction to Tramadol and Withdrawal Effect on the Spermatogenesis and Testicular Tissues in Adult Male Albino Rats
Conclusions: It could be concluded that the administration of tramadol causes abnormalities on testicular tissues associated with oxidative stress, which confirmed the risk of increased oxidative stress on testicular tissues due to tramadol abuse.Pharmacology 2019;103:202 –211 (Source: Pharmacology)
Source: Pharmacology - January 31, 2019 Category: Drugs & Pharmacology Source Type: research
Shenduning Granule Attenuates Renal Injury from Oxidative Stress through the Nuclear Factor Erythroid 2-Related Factor 2/Antioxidant Response Element Pathway
Conclusion: Shenduning granule can improve renal antioxidative stress activity in rats, exhibiting a renoprotective effect. The potential mechanism is likely exerted by the activation of the Nrf2/ARE pathway.Pharmacology 2019;103:236 –245 (Source: Pharmacology)
Source: Pharmacology - January 31, 2019 Category: Drugs & Pharmacology Source Type: research
< b > < i > Panax Notoginseng < /i > < /b > Extract Possesses Significant Antibacterial Activity against Pathogenic Streptococci
Conclusion: Our findings suggested that PNE inhibitedS. pyogenes without affecting oral commensal bacteria. Therefore, PNE could be used for the treatment ofS. pyogenes infections.Pharmacology 2019;103:221 –227 (Source: Pharmacology)
Source: Pharmacology - January 28, 2019 Category: Drugs & Pharmacology Source Type: research
