Involvement of miR-769-5p/Retinoic Acid Receptor Responder 1 Axis in the Progression of Osteosarcoma: Characterization of Potential Therapeutic Targets
Conclusion: miR-769-5p promoted cell viability, invasion, and migration by reducing RARRES1 expression in osteosarcoma cells, which might provide novel targets for the treatment of osteosarcoma.Pharmacology (Source: Pharmacology)
Source: Pharmacology - February 11, 2022 Category: Drugs & Pharmacology Source Type: research
Anesthetic Pharmacology of the Mint Extracts L-Carvone and Methyl Salicylate
Conclusion: L-Carvone and methyl salicylate allosterically modulate cell receptor targets important to molecular actions of conventional anesthetics at concentrations that also induce general anesthesia in rats.Pharmacology (Source: Pharmacology)
Source: Pharmacology - January 31, 2022 Category: Drugs & Pharmacology Source Type: research
Therapeutic Potential of Cannabis, Cannabidiol, and Cannabinoid-Based Pharmaceuticals
Background: There is a growing interest in the use of cannabis (and its extracts), as well as CBD oil (hemp extracts containing cannabidiol), for therapeutic purposes. While there is reason to believe that cannabinoids may be efficacious for a number of different diseases and syndromes, there exist limited objective data supporting the use of crude materials (CBD oil, cannabis extracts, and/or cannabis itself).Summary: In the present review, we examined data for pure cannabinoid compounds (dronabinol, nabilone, and CBD), as well as partially purified medicinal cannabis extracts (nabiximols), to provide guidance on the pote...
Source: Pharmacology - January 28, 2022 Category: Drugs & Pharmacology Source Type: research
Determination of Afatinib in Human Plasma by 2-Dimensional Liquid Chromatography
Conclusion: The results indicated that this method was useful for the therapeutic drug monitoring of afatinib and suitable for the assessment of the risks and benefits of chemotherapy in patients with non-small cell lung cancer.Pharmacology (Source: Pharmacology)
Source: Pharmacology - January 27, 2022 Category: Drugs & Pharmacology Source Type: research
Influence of Clinically Significant Genes on Antiplatelet Effect of Clopidogrel and Clinical Outcomes in Patients with Acute Coronary Syndrome and Atrial Fibrillation
Conclusion: In our study, we determined that carriers of CYP4F2 gene polymorphisms C(Val433Met)T, PEAR1 rs41273215 C#x3e;T (CT+TT) were associated with lower safety of antithrombotic therapy in patients with ACS and AF. And, the B4GALT2 rs1061781 gene polymorphism was associated with a greater risk of insufficient efficacy of the therapy. The data obtained in our study may improve the understanding of the effect of less studied genetic markers on the efficacy and safety of antithrombotic therapy in patients with ACS and AF.Pharmacology (Source: Pharmacology)
Source: Pharmacology - January 24, 2022 Category: Drugs & Pharmacology Source Type: research
< b > < i > Angelica acutiloba < /i > < /b > Exerts Antihypertensive Effect and Improves Insulin Resistance in Spontaneously Hypertensive Rats Fed with a High-Fat Diet
Conclusion: AAE has an antihypertensive effect, suppresses stress-induced hypertension, and improves insulin resistance in HFD-fed SHRs. The suppression of brain ACE activity, sympathetic nerve activity, and inflammation are partly involved in the effects of AAE.Pharmacology (Source: Pharmacology)
Source: Pharmacology - January 17, 2022 Category: Drugs & Pharmacology Source Type: research
Dexrazoxane Alleviated Doxorubicin-Induced Nephropathy in Rats
Conclusion: Our results suggest DZR exerted its protective effects against DOX-induced nephropathy through inhibition of lipid peroxidation, apoptosis, and fibrosis.Pharmacology (Source: Pharmacology)
Source: Pharmacology - January 12, 2022 Category: Drugs & Pharmacology Source Type: research
Asperulosidic Acid, a Bioactive Iridoid, Alleviates Placental Oxidative Stress and Inflammatory Responses in Gestational Diabetes Mellitus by Suppressing NF- κB and MAPK Signaling Pathways
Conclusion: ASP alleviates placental oxidative stress and inflammatory responses in GDM by the inhibition of the NF- κB and MAPK signaling pathways.Pharmacology (Source: Pharmacology)
Source: Pharmacology - January 10, 2022 Category: Drugs & Pharmacology Source Type: research
Decreased Hyperpolarization-Activated Cyclic Nucleotide-Gated Channel 2 Activity in a Rat Model of Absence Epilepsy and the Effect of ZD7288, an < b > < i > Ih < /i > < /b > Inhibitor, on the Spike-and-Wave Discharges
Conclusion: TheIh inhibitor ZD7288 increased the number of SWDs in a genetic absence epilepsy rat model, although this increase may not be significant due to the inconsistent time-dependent effects. In GAERS, the cortical and hippocampal HCN2 channel levels were significantly lower compared to the control group. Further studies are needed with higher doses of ZD7288 to determine if the effects will increase drastically.Pharmacology (Source: Pharmacology)
Source: Pharmacology - January 10, 2022 Category: Drugs & Pharmacology Source Type: research
Effects of Sodium-Glucose Cotransporter 2 on Amputation Events: A Systematic Review and Meta-Analysis of Randomized-Controlled Trials
Conclusions: In this meta-analysis, SGLT2 inhibitors were not associated with a significant difference in amputation events.Pharmacology (Source: Pharmacology)
Source: Pharmacology - December 23, 2021 Category: Drugs & Pharmacology Source Type: research
Soluble Guanylate Cyclase-Mediated Relaxation in Aortas from Rats with Renovascular Hypertension
Soluble guanylate cyclase (sGC) plays an important role in nitric oxide (NO)-mediated regulation of vascular tone; however, NO bioavailability is often reduced in diseased blood vessels. Accumulating evidence suggests that a shift of sGC from the NO-sensitive form to the NO-insensitive form could be an underlying cause contributing to this reduction. Herein, we investigated the impact of renovascular hypertension on NO-sensitive and NO-insensitive sGC-mediated relaxation in rat aortas. Renovascular hypertension was induced by partially clipping the left renal artery (2-kidneys, 1-clip; 2K1C) for 10 weeks. Systolic, diastol...
Source: Pharmacology - December 20, 2021 Category: Drugs & Pharmacology Source Type: research
Therapeutic Potential of Sunitinib in Ameliorating Endothelial Dysfunction in Type 2 Diabetic Rats
Conclusions: This study demonstrates that sunitinib has a glucose-lowering effect and ameliorates endothelial dysfunction in both conduit and resistance arteries of GK rats.Pharmacology (Source: Pharmacology)
Source: Pharmacology - December 20, 2021 Category: Drugs & Pharmacology Source Type: research
5-Aminosalicylic Acid, A Weak Agonist for Aryl Hydrocarbon Receptor That Induces Splenic Regulatory T Cells
Discussion: These results suggest that 5-ASA is a weak agonist of AhR and thereby induces Tregs in spleen cells. Our findings may provide useful insights into the mechanism by which 5-ASA regulates inflammation.Pharmacology (Source: Pharmacology)
Source: Pharmacology - December 16, 2021 Category: Drugs & Pharmacology Source Type: research
Curcumin and Its Analogs as Potential Epigenetic Modulators: Prevention of Diabetes and Its Complications
Background: The pathobiology of diabetes and associated complications has been widely researched in various countries, but effective prevention and treatment methods are still insufficient. Diabetes is a metabolic disorder of carbohydrates, fats, and proteins caused by an absence of insulin or insulin resistance, which mediates an increase of oxidative stress, release of inflammatory factors, and macro- or micro-circulation dysfunctions, ultimately developing into diverse complications.Summary: In the last decade through pathogenesis research, epigenetics has been found to affect metabolic diseases. Particularly, DNA methy...
Source: Pharmacology - December 15, 2021 Category: Drugs & Pharmacology Source Type: research
Tadalafil in Increasing Doses: The Influence on Coronary Blood Flow and Oxidative Stress in Isolated Rat Hearts
Conclusion: Tadalafil causes changes in the heart vasculature in a dose-dependent manner. It does not lead to a significant increase in the production of superoxide anion radicals.Pharmacology (Source: Pharmacology)
Source: Pharmacology - December 10, 2021 Category: Drugs & Pharmacology Source Type: research
