Inhibition of Recombinant Human Acetylcholinesterase Activity by Antipsychotics
Conclusion: Aripiprazole may cause EPS at clinical dosages by augmenting cholinergic effects via AChE inhibition, in addition to its suppressive effect on dopaminergic neurons.Pharmacology 2019;104:43 –50 (Source: Pharmacology)
Source: Pharmacology - May 8, 2019 Category: Drugs & Pharmacology Source Type: research
Utility of Mesalazine in Familial Adenomatous Polyposis: Clinical Report of Reduction of Polyp Size in Patients with Ulcerative Colitis, and Safety Examination in Familial Adenomatous Polyposis Patients
This report provides basic information for planning a double-blind, randomized, clinical trial that aims to show mesalazine ’s potential to suppress intestinal polyp development in FAP.Pharmacology 2019;104:51 –56 (Source: Pharmacology)
Source: Pharmacology - May 8, 2019 Category: Drugs & Pharmacology Source Type: research
The First Pediatric Case of Acute Generalized Exanthematous Pustulosis Caused by Hydroxychloroquine
Conclusion: Our patient represents the first pediatric case of AGEP to HCQ, posing such a drug as a possible trigger also in children. Therefore, an accurate drug medical history is mandatory in order to rule out potential drug reactions when facing a sudden rash.Pharmacology 2019;104:57 –59 (Source: Pharmacology)
Source: Pharmacology - May 8, 2019 Category: Drugs & Pharmacology Source Type: research
Estimation of Phenytoin Pharmacokinetic Parameters in Saudi Epileptic Patients
Conclusion: The population pharmacokinetic model of phenytoin in Saudi patients found significant interindividual variability between subjects, which was affected by the patients ’ age, body weight, and VPA cotherapy as the most significant covariates on phenytoin Vmax and Km. To provide guidance in drug dosage decisions, further studies are required to evaluate all factors that may potentially influence the pharmacokinetics of phenytoin.Pharmacology 2019;104:60 –66 (Source: Pharmacology)
Source: Pharmacology - May 8, 2019 Category: Drugs & Pharmacology Source Type: research
Antitumor Effects of Chrysophanol in Malignant Optic Nerve Meningioma Cell Lines are Mediated via Caspase Activation, Induction of Mitochondrial Mediated Apoptosis, Mitochondrial Membrane Depolarization and Targeting the Mitogen-Activated Protein Kinase Signaling Pathway
Conclusion: The findings of the present study suggest that chrysophanol may prove beneficial in the treatment of malignant meningioma of optic nerve.Key Message: The study revealed the anticancer potential of chrysophanol against the malignant optic nerve meningioma.Pharmacology 2019;104:28 –35 (Source: Pharmacology)
Source: Pharmacology - May 5, 2019 Category: Drugs & Pharmacology Source Type: research
The Effects of < b > < i > Lysimachia christinae Hance < /i > < /b > Extract Fractions on Endothelium-Dependent Vasodilatation
Conclusions: These results suggest that the NB fraction possess the strongest vascular pharmacological activities among the crude ethanolic extract ofL. christinae Hance, which may help us for purifying bioactive constituents and discovering new drugs from this herb in future.Pharmacology 2019;104:36 –42 (Source: Pharmacology)
Source: Pharmacology - May 5, 2019 Category: Drugs & Pharmacology Source Type: research
Pharmacokinetic Characterizations of Ginsenoside Ocotillol, RT < sub > 5 < /sub > and F < sub > 11 < /sub > , the Promising Agents for Alzheimer ’s Disease from American Ginseng, in Rats and Beagle Dogs
Conclusions: This was the first PK investigation of the ocotillol type ginsenosides in rats and beagle dogs. The results we found here were helpful to our understanding of the absorption mechanism of ocotillol type ginsenosides and provided the scientific basis for further pre-clinical research.Pharmacology 2019;104:7 –20 (Source: Pharmacology)
Source: Pharmacology - April 15, 2019 Category: Drugs & Pharmacology Source Type: research
A Comparison of the Anti-Inflammatory Effects of Four Combined Statin and Antiplatelet Therapies on Tumor Necrosis Factor-Mediated Acute Inflammation < b > < i > in vivo < /i > < /b >
Conclusions: The combination therapy comprising cilostazol and statins, particularly pravastatin, exerted the best anti-TNF effect compared with clopidogrel and statin therapy; thus, a suitable combination therapy, such as CILOP, can be a potential remedy to cure TNF-related diseases.Pharmacology 2019;104:21 –27 (Source: Pharmacology)
Source: Pharmacology - April 15, 2019 Category: Drugs & Pharmacology Source Type: research
Contents
Pharmacology 2019;103:I –IV (Source: Pharmacology)
Source: Pharmacology - April 15, 2019 Category: Drugs & Pharmacology Source Type: research
Administration of Curcumin Alleviates Neuropathic Pain in a Rat Model of Brachial Plexus Avulsion
Conclusions: Our findings suggest that curcumin significantly extenuates the BPA-induced pain and inflammation by reducing the expression level of proinflammatory cytokines and pain-associated proteins and inhibiting the activity of astrocytes.Pharmacology 2019;103:324 –331 (Source: Pharmacology)
Source: Pharmacology - April 3, 2019 Category: Drugs & Pharmacology Source Type: research
Effect of Evening Bromazepam Administration on Blood Pressure and Heart Rate in Mild Hypertensive Patients
Conclusions: In mild hypertensive patients, evening consumption of bromazepam for a 2-week period did not affect BP, while it increased nocturnal HR. Such an increase was observed both when bromazepam was taken alone and in combination with propranolol, which suggests that it depends on a bromazepam mediated decrease in vagal tone. Whatever the mechanism, the HR nocturnal increase might be of clinical relevance, due to the role of high HR as cardiovascular risk factor, particularly in already at risk hypertensive subjects.Pharmacology 2019;104:1 –6 (Source: Pharmacology)
Source: Pharmacology - April 3, 2019 Category: Drugs & Pharmacology Source Type: research
High-Level Mupirocin Resistance in < b > < i > Staphylococcus < /i > < /b > spp. among Health Care Workers in a Tertiary Care Hospital
Conclusion: The identification of Mupirocin resistance will guide us to utilize the antibiotic in a judicious way to treat the nasal carriage effectively.Pharmacology 2019;103:320 –323 (Source: Pharmacology)
Source: Pharmacology - March 20, 2019 Category: Drugs & Pharmacology Source Type: research
Effect of Caffeic Acid on Ischemia-Reperfusion-Induced Acute Renal Failure in Rats
Conclusion: This study demonstrated the renoprotective potential of CA and combination of CA + CEL in IR-induced ARF in rats. The plausible mechanisms for the efficacy of CA could be attributed to its ability to modulate the COX-LOX system in renal IR.Pharmacology 2019;103:315 –319 (Source: Pharmacology)
Source: Pharmacology - March 14, 2019 Category: Drugs & Pharmacology Source Type: research
Cardioprotective Effect of Rhapontigenin in Isoproterenol-Induced Myocardial Infarction in a Rat Model
Conclusion: RPG ameliorates MI caused by ISO in rats and provides cardioprotective effect, via anti-inflammatory, antioxidant, and antiapoptotic effect.Pharmacology 2019;103:291 –302 (Source: Pharmacology)
Source: Pharmacology - March 7, 2019 Category: Drugs & Pharmacology Source Type: research
Epigallocatechin-3-Gallate Attenuates Adriamycin-Induced Focal Segmental Glomerulosclerosis via Suppression of Oxidant Stress and Apoptosis by Targeting Hypoxia-Inducible Factor-1 α/ Angiopoietin-Like 4 Pathway
Conclusion: EGCG attenuates FSGS through the suppression of Oxidant Stress and apoptosis by targeting the HIF-1 α/ANGPTL4 pathway.Pharmacology 2019;103:303 –314 (Source: Pharmacology)
Source: Pharmacology - March 7, 2019 Category: Drugs & Pharmacology Source Type: research
