Effect of Mineralocorticoid Receptor Antagonists on the Prognosis of Patients with Ventricular Tachyarrhythmias
Conclusion: In patients with ventricular tachyarrhythmias, treatment with MRA was not associated with improved all-cause mortality at 3 years. The therapeutic effect of MRA treatment in patients with ventricular tachyarrhythmias needs to be reinvestigated within further randomized controlled trials.Pharmacology (Source: Pharmacology)
Source: Pharmacology - December 8, 2021 Category: Drugs & Pharmacology Source Type: research
Induced Polyspecificity of Human Secretory Immunoglobulin A Antibodies: Is It Possible to Improve Their Ability to Bind Pathogens?
Conclusions: Thus, it was shown that all investigated treatments can alter to some degree the antigen-binding of secretory IgA, but acidic pH has the most potentially beneficial effect by increasing binding to a largest number of common pathogens ’ antigens.Pharmacology (Source: Pharmacology)
Source: Pharmacology - December 3, 2021 Category: Drugs & Pharmacology Source Type: research
Pregnane-Oximino-Alkyl-Amino-Ether Compound as a Novel Class of TGR5 Receptor Agonist Exhibiting Antidiabetic and Anti-Dyslipidemic Activities
Conclusion: Compound14b exhibits antidiabetic and anti-dyslipidemic activities through activating the TGR5 receptor system and can be developed as a lead for the management of type II diabetes and related metabolic complications.Pharmacology (Source: Pharmacology)
Source: Pharmacology - November 23, 2021 Category: Drugs & Pharmacology Source Type: research
Erratum
Pharmacology (Source: Pharmacology)
Source: Pharmacology - November 23, 2021 Category: Drugs & Pharmacology Source Type: research
Effects of Fatty Acid Amide Hydroxylase Inhibitor URB597 on the Catecholaminergic Activity of the Adrenal Medulla in Stressed Male and Female Rats
Discussion: Our results support the role of endocannabinoids as an antistress mechanism that inhibits elevated adrenomedullary activation and promotes its recovery to baseline in both male and female stressed rats.Pharmacology (Source: Pharmacology)
Source: Pharmacology - November 18, 2021 Category: Drugs & Pharmacology Source Type: research
Effects of Increased Central Cholinergic Activity on the Metabolic Challenge Induced by Submaximal Exercise in Rats: Adrenomedullary Secretion Influences
Conclusion: These results indicate that there is a dual metabolic control by which activation of the central cholinergic pathway increases plasma glucose but not FFA during rest and exercise, and that this hyperglycemic response is dependent on adrenomedullary secretion.Pharmacology (Source: Pharmacology)
Source: Pharmacology - November 17, 2021 Category: Drugs & Pharmacology Source Type: research
Validation of Fenoterol to Study β < sub > 2 < /sub > -Adrenoceptor Function in the Rat Urinary Bladder
Fenoterol is a β2-adrenoceptor (AR)-selective agonist that is commonly used to investigate relaxation responses mediated by β2-AR in smooth muscle preparations. Some data have questioned this because fenoterol had low potency in the rat urinary bladder when a muscarinic agonist was used as a pre-contraction agent and because some investigators proposed that fenoterol may act in part via β3-AR. We designed the present study to investigate whether fenoterol is a proper pharmacological tool to study β2-AR-mediated relaxation responses in the rat urinary bladder. Firstly, we have compared the effect of pre-contraction agen...
Source: Pharmacology - November 15, 2021 Category: Drugs & Pharmacology Source Type: research
Contents Vol. 106, 2021
Pharmacology 2021;106:I –VI (Source: Pharmacology)
Source: Pharmacology - November 9, 2021 Category: Drugs & Pharmacology Source Type: research
Acknowledgement to Referees
Pharmacology 2021;106:695 –696 (Source: Pharmacology)
Source: Pharmacology - November 9, 2021 Category: Drugs & Pharmacology Source Type: research
A Novel Partial PPAR γ Agonist Has Weaker Lipogenic Effect in Adipocytes and Stimulates GLUT4 Translocation in Skeletal Muscle Cells via AMPK-Dependent Signaling
Conclusion: GS2 may be a promising therapeutic agent for the treatment of insulin resistance and type 2 diabetes mellitus without adiposity.Pharmacology (Source: Pharmacology)
Source: Pharmacology - November 4, 2021 Category: Drugs & Pharmacology Source Type: research
Dexmedetomidine Attenuates Hypoxia/Reoxygenation Injury of H9C2 Myocardial Cells by Upregulating miR-146a Expression via the MAPK Signal Pathway
Conclusion: Dex might regulate miR-146a expression, which could further modulate the endoplasmic reticulum stress and oxidative stress and eventually affect the cell viability and apoptosis of myocardial cells injured by H/R via the MAPK signal pathway.Pharmacology (Source: Pharmacology)
Source: Pharmacology - October 29, 2021 Category: Drugs & Pharmacology Source Type: research
Impact of Ghrelin on Ventricular Arrhythmia and Related Mechanism After Myocardial Infarction
Conclusion: Ghrelin provides a sustained electrophysiological protection by the increase of VFT and improvement of APD dispersion and APD alternans. The mechanism may be related to the regulation of autonomic nerve and sympathetic nerve remodeling. Thus, ghrelin represents a novel drug to prevent ventricular arrhythmia in ischemic heart disease.Pharmacology (Source: Pharmacology)
Source: Pharmacology - October 29, 2021 Category: Drugs & Pharmacology Source Type: research
Assessment of Drug Interactions with Online Electronic Checkers in Multi-Pathological Patients
Conclusions: The 3 online checkers we assessed found a large number of interactions. The 3 programs gave very discrepant results.Impact on Practice Statements: The analyzed programs, Drugs.com, Lexicomp ®, and Medscape Interactions, found a large number of drug interactions in the studied patients. The 3 programs gave very discrepant results among them.Pharmacology (Source: Pharmacology)
Source: Pharmacology - October 25, 2021 Category: Drugs & Pharmacology Source Type: research
A Risk-Prediction Nomogram for Neutropenia or Febrile Neutropenia after Etoposide-Based Chemotherapy in Cancer Patients: A Retrospective Cohort Study
Conclusion: This model can aid the early identification and screening of the potential risk of neutropenia or FN in the first cycle of treatment for patients using etoposide-based chemotherapy.Pharmacology (Source: Pharmacology)
Source: Pharmacology - October 21, 2021 Category: Drugs & Pharmacology Source Type: research
Efficacy of Icotinib, an EGFR Tyrosine Kinase Inhibitor in Non-Small Cell Lung Cancer Patients with Exon 19 Deletion and Exon 21 L858R: A Retrospective Analysis in China
Conclusion: These results suggest thatEGFR 19-Del confers superior PFS and response to the icotinib treatment compared to 21-L858R.Pharmacology (Source: Pharmacology)
Source: Pharmacology - October 21, 2021 Category: Drugs & Pharmacology Source Type: research
