MiR-224 Executes a Tumor Accelerative Role during Hepatocellular Carcinoma Malignancy by Targeting Cytoplasmic Polyadenylation Element-Binding Protein 3
Conclusion: Our data provided evidences that miR-224 is implicated in HCC cell proliferation and motility via targeting CPEB3. The relationship between miR-224 and CPEB3 might be a novel finding, and miR-224/CPEB3 axis might be markers for providing therapeutic and prognostic information in HCC.Pharmacology (Source: Pharmacology)
Source: Pharmacology - May 26, 2020 Category: Drugs & Pharmacology Source Type: research
YiQi GuBen Formula Inhibits PDGF-BB-Induced Proliferation and Migration of Airway Smooth Muscle Cells
Conclusions: In summary, our study shows that YiQi GuBen formula is able to significantly inhibit PDGF-BB-induced ASMC proliferation and migration by suppressing the NF- κB signaling pathway.Pharmacology (Source: Pharmacology)
Source: Pharmacology - May 26, 2020 Category: Drugs & Pharmacology Source Type: research
Erratum
Pharmacology (Source: Pharmacology)
Source: Pharmacology - May 26, 2020 Category: Drugs & Pharmacology Source Type: research
MicroRNA-591 Functions as a Tumor Suppressor in Hepatocellular Carcinoma by Lowering Drug Resistance through Inhibition of Far-Upstream Element-Binding Protein 2-Mediated Phosphoinositide 3-Kinase/Akt/Mammalian Target of Rapamycin Axis
In this study, we hypothesize an inhibitory role of miR-591 in HCC via regulating FBP2. Next, reverse transcription quantitative polymerase chain reaction found that FBP2 expressed highly and miR-591 expresses poorly in HCC tissues. Then, the negative correlation between miR-591 and mRNA expression of FBP2 was identified by Pearson ’s correlation coefficient, and putative miR-591-binding sites on the 3′-untranslated region of FBP2 was validated using a dual-luciferase reporter gene assay. After the expression of miR-591 and FBP2 was altered in the drug-resistant CD133+/CD44+ cells, a series of in vitro and in vivo expe...
Source: Pharmacology - July 5, 2019 Category: Drugs & Pharmacology Source Type: research
Design and Development of Novel 1,3,5-Triazine-Procaine Derivatives as Protective Agent against Myocardial Ischemia/Reperfusion Injury via Inhibitor of Nuclear Factor- κB
The aim of the present study was to determine the protective effect of novel 1,3,5-triazine-procaine derivatives against myocardial ischemia/reperfusion (I/R) injury. Initially, the experiment has been started by the synthesis of procaine, which later got substituted with diverse 1,3,5-triazine derivatives to furnish the final compounds. The target compounds were tested for nuclear factor- κB (NF-κB) inhibitory activity in lipopolysaccharide (LPS)-stimulated RAW264.7 cells. The antioxidant activity of most potent compound 9i was investigated using hydroxyl radical, DPPH, and superoxide anion scavenging assay. Compound 9i...
Source: Pharmacology - June 18, 2019 Category: Drugs & Pharmacology Source Type: research
The Transient Receptor Potential Vanilloid 4 Agonist RN-1747 Inhibits the Calcium Response to Histamine
Conclusion: The TRPV4 agonist RN-1747, and possibly also the structurally similar TRPV4 antagonist RN-1734, should be used with caution because of yet unidentified interference with histamine signaling via H1R.Pharmacology (Source: Pharmacology)
Source: Pharmacology - June 18, 2019 Category: Drugs & Pharmacology Source Type: research
The Local Anaesthetic Lignocaine Exhibits Potent Antilung Cancer Cell Activity by Inhibiting the Phosphoinositide 3-Kinases/Mammalian Target of Rapamycin/Mammalian Target of Rapamycin Pathway
In conclusion, our results suggest that LIG may be a useful therapy for human lung carcinoma.Pharmacology (Source: Pharmacology)
Source: Pharmacology - June 14, 2019 Category: Drugs & Pharmacology Source Type: research
Oral Anticoagulation Therapy and Progression of Calcific Aortic Valve Stenosis: Factor Xa versus Factor IIa Inhibition?
Pharmacology (Source: Pharmacology)
Source: Pharmacology - June 11, 2019 Category: Drugs & Pharmacology Source Type: research
Insulin Suppresses Type 1 Diabetes Mellitus-Induced Ventricular Cardiomyocyte Damage Associated with the Inhibition of Biomarkers of Inflammation and Oxidative Stress in Rats
Conclusions: These results indicate that insulin effectively suppresses left ventricular cardiomyocyte ultrastructural damage, which substantially slows down the progression of diabetic cardiomyopathy for 8 weeks in a rat model of T1DM, possibly due to the glycemic control and inhibition of dyslipidemia, OxS and inflammation.Pharmacology (Source: Pharmacology)
Source: Pharmacology - June 11, 2019 Category: Drugs & Pharmacology Source Type: research
In vitro Antimicrobial Effects of Virus Block, Which Contains Multiple Polyoxometalate Compounds, and Hygienic Effects of Virus Block-Supplemented Moist Hand Towels
Conclusions: The effects of VB and PMs were superior to those of commercial moist hand towels, indicating that effective data were obtained that may be useful for the practical application of the tested items.Pharmacology (Source: Pharmacology)
Source: Pharmacology - June 6, 2019 Category: Drugs & Pharmacology Source Type: research
Discovery of Glabridin as Potent Inhibitor of Epidermal Growth Factor Receptor in SK-BR-3 Cell
In this study, we have demonstrated that GBN causes reduction of cellular viability of human breast cancer SK-BR-3 in MTT assay. Results from Hoechst 33342 and propidium iodide staining assay suggested that GBN causes significant enhancement in the apoptosis. At the molecular level, in western blot analysis, GBN causes significant increase in c-PARP and c-caspases 3, 8, and 9 concentrations in a dose-dependent manner in breast cancer cells. The GBN further showed reduced level of p-epidermal growth factor receptor, p-AKT, p-ERK1/2, and cyclin D1 as the concentration rose in treated cells. Subsequent to this, GBN showed ben...
Source: Pharmacology - June 5, 2019 Category: Drugs & Pharmacology Source Type: research
Aloperine Activates the PI3K/Akt Pathway and Protects Against Coronary Microembolisation-Induced Myocardial Injury in Rats
Conclusions: ALO can inhibit cardiomyocyte apoptosis and consequently attenuate CME-induced myocardial injury. These functions are realised by activating PI3K/Akt signalling pathway.Pharmacology 2019;104:90 –97 (Source: Pharmacology)
Source: Pharmacology - June 4, 2019 Category: Drugs & Pharmacology Source Type: research
Calycosin Inhibits Intestinal Fibrosis on CCD-18Co Cells via Modulating Transforming Growth Factor- β/Smad Signaling Pathway
Conclusion: This study demonstrated that CA could inhibit the activation of CCD-18Co cells and reduce the expression of extracellular matrix. Our study highlighted that CA-inhibited TGF- β/Smad pathway through inhibiting the expression of p-Smad2, p-Smad3, Smad4, and TGF-β1 and raised the Smad7 expression. Therefore, CA might inhibit intestinal fibrosis by inhibiting the TGF-β/Smad pathway.Pharmacology 2019;104:81 –89 (Source: Pharmacology)
Source: Pharmacology - June 4, 2019 Category: Drugs & Pharmacology Source Type: research
Pterostilbene Ameliorates Nephropathy Injury in Streptozotocin-Induced Diabetic Rats
Conclusion: PS had potential therapeutic effects on DN, which may be related to the regulation of NF- κB pathway.Pharmacology 2019;104:71 –80 (Source: Pharmacology)
Source: Pharmacology - May 22, 2019 Category: Drugs & Pharmacology Source Type: research
Paliperidone Use in Child Psychiatry: Evidence or Diffidence?
Conclusion: Paliperidone has some dynamic and kinetic superiority to the parent drug risperidone. Nonetheless, larger rigorous studies would define the real place of the atypical antipsychotic paliperidone in child and adolescent psychiatry. Until then, risperidone with its long track record in CAP population would remain a first option though.Pharmacology 2019;104:67 –70 (Source: Pharmacology)
Source: Pharmacology - May 17, 2019 Category: Drugs & Pharmacology Source Type: research
