Paliperidone Use in Child Psychiatry: Evidence or Diffidence?

Conclusion: Paliperidone has some dynamic and kinetic superiority to the parent drug risperidone. Nonetheless, larger rigorous studies would define the real place of the atypical antipsychotic paliperidone in child and adolescent psychiatry. Until then, risperidone with its long track record in CAP population would remain a first option though.Pharmacology 2019;104:67 –70
Source: Pharmacology - Category: Drugs & Pharmacology Source Type: research

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Publication date: December 2019Source: Results in Physics, Volume 15Author(s): Mohammad Karbalaei, Daryoosh Dideban, Hadi HeidariAbstractThis paper presents the electrical characteristics of a short channel Silicon on Insulator (SOI) transistor with a graphene layer. The graphene sheet is used at the bottom of the channel close to the source side and a proportionally heavily p-type retrograde doping implanted in nearly middle of the channel. To increase the gate electrostatic control over the channel we incorporated a high-K material i.e. HfO2 as the gate oxide insulator. Due to Graphene growth and Retrograde Doping in the...
Source: Results in Physics - Category: Physics Source Type: research
Authors: Yamashita K, Ghafoori E, Silvernagel J, Ashton J, J Dosdall D, MacLeod R, Ranjan R Abstract Radiofrequency (RF) ablation results in creation of acute edema which can lead to temporary disruption of electrical propagation.The goal of this study was to find the effective contact force (CF) to minimize edema formation in comparison to the lesion size.Ventricular RF lesions (n = 49) were created by a CF-sensing catheter in a canine model (n = 10) with varying force for 30 seconds. Animals underwent T2-weighted (T2w) and late gadolinium enhancement MRI (LGE-MRI) immediately after ablation and at 12 weeks. Acute...
Source: International Heart Journal - Category: Cardiology Tags: Int Heart J Source Type: research
ConclusionsThe presence of TD is associated with worse HRQoL and social withdrawal. The most severe impact of TD is on physical aspects of patients ’ HRQoL.
Source: Quality of Life Research - Category: Health Management Source Type: research
Authors: Brodowski L, Büter W, Kohls F, Hillemanns P, von Kaisenberg C, Dammann O Abstract Maternal overweight and obesity are prenatal risk factors for obstetrical complications, preterm birth, neonatal morbidity as well as cognitive and behavioural developmental disorders in children. Paediatric morbidity and mortality as well as child development disorders are significantly associated with maternal obesity. Particularly in the neurodevelopmental and psychiatric area, it is becoming increasingly clear that, in children of mothers with an increased body mass index (BMI), there is a high correlation with child...
Source: Geburtshilfe und Frauenheilkunde - Category: OBGYN Tags: Geburtshilfe Frauenheilkd Source Type: research
The objective of this study was to explore suicidal behavio...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Research Methods, Surveillance and Codes, Models Source Type: news
BACKGROUND: Suicide is one of the leading causes of death in bipolar disorder (BD); violent suicide attempts are associated with the highest level of lethality. We aimed to evaluate factors related to the risk of violent suicide in a large naturalistic sam...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Suicide and Self-Harm Source Type: news
Asking this question on behalf of a pediatric colleague. " I've been using the original Quotient ADHD test in my office for the last ten years Quotient ADHD Test The Quotient ADHD Test objectively measures hyperactivity, impulsivity and inattention to aid assessment of ADHD. The test reports micro-motion and analyzes shifts in attention state, helping to engage patients and guardians in the treatment planning process. Unfortunately, the original Quo...
Source: Student Doctor Network - Category: Universities & Medical Training Authors: Tags: Psychiatry Source Type: forums
, Eating Disorder Working Group of the PGC, Major Depressive Disorder Working Group of the PGC, Obsessive Compulsive Disorders and Tourette Syndrome Working Group of the PGC, Schizophrenia CLOZUK, Substance Use Disorder Working Group of the PGC, Agrawal A, Børglum AD, Bulik CM, Daly MJ, Davis LK, Demontis D, Edenberg HJ, Grove J, Gelernter J, Neale BM, Pardiñas AF, Stahl E, Walters JTR, Walters R, Sullivan PF, Posthuma D, Polderman TJC PMID: 30334498 [PubMed - as supplied by publisher]
Source: Psychological Medicine - Category: Psychiatry Authors: Tags: Psychol Med Source Type: research
CONCLUSIONS: Given the unique character of each study design, the convergent findings for these eight psychiatric conditions suggest that heritability estimates are robust across different methods. The findings also highlight large differences in genetic and environmental influences between psychiatric disorders, providing future directions for etiological psychiatric research. PMID: 30221610 [PubMed - as supplied by publisher]
Source: Psychological Medicine - Category: Psychiatry Authors: Tags: Psychol Med Source Type: research
In recent years, prescriptions of atypical antipsychotic drugs (APDs) (mostly off-label use, particularly olanzapine, risperidone and aripiprazole), in children and adolescents have been dramatically increased for treating various mental disorders, such as childhood-onset schizophrenia, bipolar disorder, autism, attention deficit hyperactivity disorder, and Tourette's disorder (Ronsley et al., 2013). These APDs target multiple neurotransmission receptors, particularly dopamine D2 and serotonin (5-HT)2 receptors to achieve their therapeutic action (Ginovart and Kapur, 2012; Meltzer and Massey, 2011).
Source: Psychiatry Research - Category: Psychiatry Authors: Source Type: research
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