In vitro and in vivo GABA < sub > A < /sub > Receptor Interaction of the Propanidid Metabolite 4-(2-[Diethylamino]-2-Oxoethoxy)-3-Methoxy-Benzeneacetic Acid

Conclusion: DOMBA modulation of GABAA receptors is associated with sedation in mice. Metabolites of propanidid analogues currently in development may similarly modulate GABAA, and impaired elimination of these metabolites could produce clinically relevant neurophysiologic effects.Pharmacology 2019;103:10 –16
Source: Pharmacology - Category: Drugs & Pharmacology Source Type: research