Circulating and urinary tumour DNA in urothelial carcinoma — upper tract, lower tract and metastatic disease
Nature Reviews Urology, Published online: 28 March 2023; doi:10.1038/s41585-023-00725-2Non-invasive liquid biopsies such as plasma circulating tumour DNA (ctDNA) and urinary tumour DNA (utDNA) are promising tools for urothelial carcinoma diagnosis and management. In this Review, the authors provide an overview of the different liquid biopsy technologies available, and discuss the current state as well as future perspectives of ctDNA and utDNA application in urothelial carcinoma clinical care. (Source: Nature Reviews Urology)
Source: Nature Reviews Urology - March 28, 2023 Category: Urology & Nephrology Authors: Kyle M. Rose Heather L. Huelster Joshua J. Meeks Bishoy M. Faltas Guru P. Sonpavde Seth P. Lerner Jeffrey S. Ross Philippe E. Spiess G. Daniel Grass Rohit K. Jain Ashish M. Kamat Aram Vosoughi Liang Wang Xuefeng Wang Roger Li Source Type: research
Calcium signalling pathways in prostate cancer initiation and progression
Nature Reviews Urology, Published online: 24 March 2023; doi:10.1038/s41585-023-00738-xIn this Review, the authors provide an overview of the role of calcium as a driver of prostate cancer onset and progression, and discuss the most current therapies targeting the calcium signalling machinery to treat this malignancy. (Source: Nature Reviews Urology)
Source: Nature Reviews Urology - March 24, 2023 Category: Urology & Nephrology Authors: Roberto Silvestri Vanessa Nicol ì Priyadarsini Gangadharannambiar Francesco Crea Martin D. Bootman Source Type: research
Abortion is a urology workforce issue
Nature Reviews Urology, Published online: 24 March 2023; doi:10.1038/s41585-023-00763-wThe urological workforce in the United States is substantially affected by inequitable abortion access across the nation. Female residency applicants avoid states with restrictive laws, and women urologists residing in these states are considering leaving. The urological community needs to invest in advocacy to protect the health of their members. (Source: Nature Reviews Urology)
Source: Nature Reviews Urology - March 24, 2023 Category: Urology & Nephrology Authors: Anne P. Cameron Casey A. Seideman Source Type: research
Pregnancy and parental leave in medicine and academia — a focus on urology
Nature Reviews Urology, Published online: 17 March 2023; doi:10.1038/s41585-023-00762-xConversations around pregnancy and parenting in medicine are increasingly important, especially as the number of women in medical training increases. Common challenges are experienced by women during pregnancy, parental leave, return to work and lactation, and policy suggestions can be offered to support doctors and surgeons who want to expand their families. (Source: Nature Reviews Urology)
Source: Nature Reviews Urology - March 17, 2023 Category: Urology & Nephrology Authors: Chloe E. Peters Siobhan M. Hartigan Source Type: research
Patient-reported outcomes in metastatic renal cell carcinoma trials using combinations versus sunitinib as first-line treatment
Nature Reviews Urology, Published online: 16 March 2023; doi:10.1038/s41585-023-00747-wIn this Review, Nolla and colleagues discuss the use of patient-reported outcome measures (PROMs) to assess health-related quality of life in six immunotherapy versus sunitinib clinical trials for advanced renal cell carcinoma and, following this discussion, make recommendations for future PROM use in clinical trials. (Source: Nature Reviews Urology)
Source: Nature Reviews Urology - March 16, 2023 Category: Urology & Nephrology Authors: Kyle Nolla David J. Benjamin David Cella Source Type: research
Gender differences in burnout among urologists
Nature Reviews Urology, Published online: 16 March 2023; doi:10.1038/s41585-023-00757-8Burnout is prevalent among urologists and leads to increased medical errors and decreased career satisfaction. Lack of access to mental health care and long work hours contribute to burnout in urologists; however, gender bias in the workplace, mistreatment and balancing family life responsibilities specifically predispose women urologists to burnout. (Source: Nature Reviews Urology)
Source: Nature Reviews Urology - March 16, 2023 Category: Urology & Nephrology Authors: Tiffany L. Damm M. Francesca Monn Source Type: research
Rucaparib improves PFS in patients with BRCA1/2-altered mCRPC
Nature Reviews Urology, Published online: 16 March 2023; doi:10.1038/s41585-023-00760-zRucaparib improves PFS in patients with BRCA1/2-altered mCRPC (Source: Nature Reviews Urology)
Source: Nature Reviews Urology - March 16, 2023 Category: Urology & Nephrology Authors: Louise Stone Source Type: research
Singling out the immune-suppressive TME in prostate cancer
Nature Reviews Urology, Published online: 16 March 2023; doi:10.1038/s41585-023-00758-7Singling out the immune-suppressive TME in prostate cancer (Source: Nature Reviews Urology)
Source: Nature Reviews Urology - March 16, 2023 Category: Urology & Nephrology Authors: Louise Stone Source Type: research
Temporary cessation versus continued TKI therapy for RCC
Nature Reviews Urology, Published online: 15 March 2023; doi:10.1038/s41585-023-00755-wTemporary cessation versus continued TKI therapy for RCC (Source: Nature Reviews Urology)
Source: Nature Reviews Urology - March 15, 2023 Category: Urology & Nephrology Authors: Maria Chiara Masone Source Type: research
PI5P4Kα: a target in prostate cancer?
Nature Reviews Urology, Published online: 14 March 2023; doi:10.1038/s41585-023-00759-6PI5P4Kα: a target in prostate cancer? (Source: Nature Reviews Urology)
Source: Nature Reviews Urology - March 14, 2023 Category: Urology & Nephrology Authors: Louise Stone Source Type: research
The role of GALNT7 as a potential diagnostic marker in prostate cancer
Nature Reviews Urology, Published online: 14 March 2023; doi:10.1038/s41585-023-00756-9The role of GALNT7 as a potential diagnostic marker in prostate cancer (Source: Nature Reviews Urology)
Source: Nature Reviews Urology - March 14, 2023 Category: Urology & Nephrology Authors: Maria Chiara Masone Source Type: research
Uncovering a link between COVID-19 and renal cell carcinoma
Nature Reviews Urology, Published online: 13 March 2023; doi:10.1038/s41585-023-00749-8The cellular action of SARS-CoV-2, the virus responsible for the COVID-19 global pandemic, is dependent on a specific combination of receptors and cofactors. These proteins are now known to be expressed in normal kidney tubule tissue and renal cell carcinoma cells, representing possible targets for budding therapeutic modalities. (Source: Nature Reviews Urology)
Source: Nature Reviews Urology - March 13, 2023 Category: Urology & Nephrology Authors: Samuel A. Gold Vitaly Margulis Source Type: research
The value of women urologists — individual and institutional imperatives to address salary equity
Nature Reviews Urology, Published online: 10 March 2023; doi:10.1038/s41585-023-00752-zWomen urologists receive less compensation than male urologists. Concerted individual and institutional action is necessary to value the impact that women urologists have on patients and on the entire field. (Source: Nature Reviews Urology)
Source: Nature Reviews Urology - March 10, 2023 Category: Urology & Nephrology Authors: Madeline Cancian Simone Thavaseelan Source Type: research
Detecting lymph node metastases for personalized radiotherapy in patients with prostate cancer
Nature Reviews Urology, Published online: 10 March 2023; doi:10.1038/s41585-023-00753-yDetecting lymph node metastases for personalized radiotherapy in patients with prostate cancer (Source: Nature Reviews Urology)
Source: Nature Reviews Urology - March 10, 2023 Category: Urology & Nephrology Authors: Tim Thomas Source Type: research
Allyship for women in urology
Nature Reviews Urology, Published online: 09 March 2023; doi:10.1038/s41585-023-00751-0The field of medicine has advanced towards gender equity in medical student matriculation over the past decade, but urology has lagged substantially behind other sub-specialties regarding the percentage of both women residents and women staff. This gender gap is further increased for under-represented individuals in medicine. One of the strategies to close these gaps is to create an inclusive work environment through allyship. (Source: Nature Reviews Urology)
Source: Nature Reviews Urology - March 9, 2023 Category: Urology & Nephrology Authors: Shree Agrawal-Patel Smita De Anna Zampini Samuel C. Haywood Eric A. Klein Source Type: research
