Clinical application of bladder MRI and the Vesical Imaging-Reporting And Data System
Nature Reviews Urology, Published online: 30 November 2023; doi:10.1038/s41585-023-00830-2MRI and the Vesical Imaging-Reporting And Data System are highly accurate imaging tools for bladder cancer staging. A panel of experts have agreed on their efficacy in different clinical settings for cancer care, using the Delphi methodology. This Expert Recommendation will provide guidance for future research agendas. (Source: Nature Reviews Urology)
Source: Nature Reviews Urology - November 30, 2023 Category: Urology & Nephrology Authors: Valeria Panebianco Alberto Briganti Thierry N. Boellaard James Catto Eva Comperat Jason Efstathiou Antoine G. van der Heijden Gianluca Giannarini Rossano Girometti Laura Mertens Mitsuru Takeuchi Valdair F. Muglia Yoshifumi Narumi Giacomo Novara Martina Pe Source Type: research
Idea sprint: generating research priorities for urinary stone disease
Nature Reviews Urology, Published online: 15 November 2023; doi:10.1038/s41585-023-00835-xThe escalating global prevalence of urinary stone disease and its impact on public health reflects the need to synthesize ideas that can help with the development of critical research priorities. By bringing together a forum of endourologists with the support of a funding agency, the IDEA session aimed to identify important future research topics. (Source: Nature Reviews Urology)
Source: Nature Reviews Urology - November 15, 2023 Category: Urology & Nephrology Authors: Golena Fernandez Moncaleano William W. Roberts John D. Denstedt Khurshid R. Ghani Source Type: research
Generative AI in scientific publishing: disruptive or destructive?
Nature Reviews Urology, Published online: 15 November 2023; doi:10.1038/s41585-023-00836-wArtificial intelligence (AI) has the potential to revolutionize scientific publishing. The influence of AI could be disruptive or destructive and its influence remains to be seen, but balance between the convenience and accessibility offered by AI-driven tools and the essential skills of deep scientific inquiry and communication needs to be found. (Source: Nature Reviews Urology)
Source: Nature Reviews Urology - November 15, 2023 Category: Urology & Nephrology Authors: Riccardo Bertolo Alessandro Antonelli Source Type: research
Genetic and biological drivers of prostate cancer disparities in Black men
Nature Reviews Urology, Published online: 14 November 2023; doi:10.1038/s41585-023-00828-wGenetic and ancestral factors, molecular pathways involving androgen and non-androgen receptor signalling, inflammation, epigenetics, the tumour microenvironment and tumour metabolism are posited as biological factors that potentially contribute to racial disparities in Black men with prostate cancer. (Source: Nature Reviews Urology)
Source: Nature Reviews Urology - November 14, 2023 Category: Urology & Nephrology Authors: Jun Gong Daniel M. Kim Michael R. Freeman Hyung Kim Leigh Ellis Bethany Smith Dan Theodorescu Edwin Posadas Robert Figlin Neil Bhowmick Stephen J. Freedland Source Type: research
Resolving the puzzle of same-sex sexual interactions
Nature Reviews Urology, Published online: 08 November 2023; doi:10.1038/s41585-023-00833-zSexual interactions between members of the same sex are common but the reasons for these behaviours are not always clear. Results from a study across mammals suggest that increased same-sex behaviour evolved with sociality and might reduce conflict, although increased male–male sexual interactions are associated with increased adult killing. (Source: Nature Reviews Urology)
Source: Nature Reviews Urology - November 8, 2023 Category: Urology & Nephrology Authors: C. Ruth Archer David J. Hosken Source Type: research
Bladder-sparing neoadjuvant therapy for MIBC
Nature Reviews Urology, Published online: 01 November 2023; doi:10.1038/s41585-023-00832-0Bladder-sparing neoadjuvant therapy for MIBC (Source: Nature Reviews Urology)
Source: Nature Reviews Urology - November 1, 2023 Category: Urology & Nephrology Authors: Louise Stone Source Type: research
Prognostic and therapeutic potential of senescent stromal fibroblasts in prostate cancer
Nature Reviews Urology, Published online: 31 October 2023; doi:10.1038/s41585-023-00827-xSenescent stromal fibroblasts exhibit a senescence-associated secretory phenotype, which can promote prostate cancer development, progression and resistance to therapy. Targeting senescent cells via senotherapeutics might be an attractive preventive or therapeutic option for prostate cancer. (Source: Nature Reviews Urology)
Source: Nature Reviews Urology - October 31, 2023 Category: Urology & Nephrology Authors: Joakin O. Mori Isra Elhussin W. Nathaniel Brennen Mindy K. Graham Tamara L. Lotan Clayton C. Yates Angelo M. De Marzo Samuel R. Denmeade Srinivasan Yegnasubramanian William G. Nelson Gerald V. Denis Elizabeth A. Platz Alan K. Meeker Christopher M. Heaphy Source Type: research
Hallmark discoveries in the biology of Wilms tumour
Nature Reviews Urology, Published online: 17 October 2023; doi:10.1038/s41585-023-00824-0Here, the authors describe the history of the efforts to expand knowledge of Wilms tumour biology, genetics, embryonal origin and associated syndromic and familial conditions, and to clinically apply prognostic biomarkers and development of preclinical models. (Source: Nature Reviews Urology)
Source: Nature Reviews Urology - October 17, 2023 Category: Urology & Nephrology Authors: Daniela Perotti Richard D. Williams Jenny Wegert Jack Brzezinski Mariana Maschietto Sara Ciceri David Gisselsson Samantha Gadd Amy L. Walz Rhoikos Furtwaengler Jarno Drost Reem Al-Saadi Nicholas Evageliou Saskia L. Gooskens Andrew L. Hong Andrew J. Murphy Source Type: research
Family dynamics: fathers’ smoking affects children’s epigenetics
Nature Reviews Urology, Published online: 13 October 2023; doi:10.1038/s41585-023-00829-9Family dynamics: fathers’ smoking affects children’s epigenetics (Source: Nature Reviews Urology)
Source: Nature Reviews Urology - October 13, 2023 Category: Urology & Nephrology Authors: Louise Stone Source Type: research
Frequency, morbidity and equity — the case for increased research on male fertility
Nature Reviews Urology, Published online: 12 October 2023; doi:10.1038/s41585-023-00820-4In this Expert Recommendation, the most pressing questions related to male reproductive health, spanning the spectrum of andrology, are identified. These questions encompass and highlight many opportunities to influence the wellness of future generations. (Source: Nature Reviews Urology)
Source: Nature Reviews Urology - October 12, 2023 Category: Urology & Nephrology Authors: Sarah Kimmins Richard A. Anderson Christopher L. R. Barratt Hermann M. Behre Sarah R. Catford Christopher J. De Jonge Geraldine Delbes Michael L. Eisenberg Nicolas Garrido Brendan J. Houston Niels J ørgensen Csilla Krausz Ariane Lismer Robert I. McLachla Source Type: research
Unlocking the mystery of the human Y chromosome
Nature Reviews Urology, Published online: 06 October 2023; doi:10.1038/s41585-023-00826-yMuch of the Y chromosome has remained obscure owing to the challenge of sequencing repetitive genomic regions. Recently, the Y chromosome has been fully sequenced, revealing extensive heterochromatic areas and 41 new protein-coding genes. Furthermore, 43 Y chromosomes have been sequenced, showing extensive multi-sample variation and providing promising insights into male infertility. (Source: Nature Reviews Urology)
Source: Nature Reviews Urology - October 6, 2023 Category: Urology & Nephrology Authors: Miguel G. Rojas Edoardo Pozzi Ranjith Ramasamy Source Type: research
Kidney xenotransplantation
Nature Reviews Urology, Published online: 04 October 2023; doi:10.1038/s41585-023-00825-zKidney xenotransplantation (Source: Nature Reviews Urology)
Source: Nature Reviews Urology - October 4, 2023 Category: Urology & Nephrology Authors: Louise Stone Source Type: research
Diagnostic liquid biopsy biomarkers in renal cell cancer
Nature Reviews Urology, Published online: 27 September 2023; doi:10.1038/s41585-023-00818-yIn this Review, the authors provide an overview of currently available diagnostic liquid biopsy biomarkers for renal cell carcinoma, comparing clinical potential and limitations of the three most promising liquid biomarkers: circulating tumour cells, extracellular vesicles and cell-free DNA. (Source: Nature Reviews Urology)
Source: Nature Reviews Urology - September 27, 2023 Category: Urology & Nephrology Authors: Richard C. Zieren Patricia J. Zondervan Kenneth J. Pienta Axel Bex Theo M. de Reijke Adriaan D. Bins Source Type: research
Improved phenotypic classification of male infertility to promote discovery of genetic causes
Nature Reviews Urology, Published online: 18 September 2023; doi:10.1038/s41585-023-00816-0In this Expert Recommendation, the authors provide a standardized nomenclature to improve the Human Phenotype Ontology tree with regard to the classification of non-syndromic male infertility. The implications of introducing this vocabulary in promoting communication across disciplines and institutions and in discovering novel genetic causes of non-syndromic male infertility are also discussed. (Source: Nature Reviews Urology)
Source: Nature Reviews Urology - September 18, 2023 Category: Urology & Nephrology Authors: Margot J. Wyrwoll Godfried W. van der Heijden Csilla Krausz Kenneth I. Aston Sabine Kliesch Robert McLachlan Liliana Ramos Donald F. Conrad Moira K. O ’Bryan Joris A. Veltman Frank T üttelmann Source Type: research
Accessing information in the AI age
Nature Reviews Urology, Published online: 11 September 2023; doi:10.1038/s41585-023-00819-xAccessing information in the AI age (Source: Nature Reviews Urology)
Source: Nature Reviews Urology - September 11, 2023 Category: Urology & Nephrology Authors: Louise Stone Source Type: research
