Understanding and integrating cytoreductive nephrectomy with immune checkpoint inhibitors in the management of metastatic RCC
Nature Reviews Urology, Published online: 03 July 2023; doi:10.1038/s41585-023-00776-5In this Review, the authors present the history of cytoreductive nephrectomy, discuss controversial results from clinical trials and assess future perspectives about the role of surgery in the management pathway of patients with metastatic renal cell carcinoma. (Source: Nature Reviews Urology)
Source: Nature Reviews Urology - July 3, 2023 Category: Urology & Nephrology Authors: Arighno Das Daniel D. Shapiro Juliana K. Craig E. Jason Abel Source Type: research
Effect of smoking, hypertension and lifestyle factors on kidney cancer — perspectives for prevention and screening programmes
Nature Reviews Urology, Published online: 16 June 2023; doi:10.1038/s41585-023-00781-8Known modifiable risk factors for renal cell carcinoma (RCC) include smoking, obesity and hypertension. Moreover, a potential association between other factors such as diet, dyslipidaemia and physical activity with RCC incidence is also starting to be explored. In this Review, the authors describe the most relevant modifiable risk factors for RCC, discussing the potential implications for prevention and screening programmes. (Source: Nature Reviews Urology)
Source: Nature Reviews Urology - June 16, 2023 Category: Urology & Nephrology Authors: Riccardo Campi Giacomo Rebez Tobias Klatte Eduard Roussel Idir Ouizad Alexander Ingels Nicola Pavan Onder Kara Selcuk Erdem Riccardo Bertolo Umberto Capitanio Maria Carmen Mir Source Type: research
Clinical trial design for non-muscle-invasive bladder cancer
Nature Reviews Urology, Published online: 16 June 2023; doi:10.1038/s41585-023-00789-0The heterogeneous nature of non-muscle-invasive bladder cancer is a challenge for clinical trial design. Careful consideration in clinical trial design, choice of end points and adequate patient characterization is important when evaluating new therapies. (Source: Nature Reviews Urology)
Source: Nature Reviews Urology - June 16, 2023 Category: Urology & Nephrology Authors: Wei Shen Tan Emma Hall Ashish M. Kamat John D. Kelly Source Type: research
Women in urology: the past
Nature Reviews Urology, Published online: 13 June 2023; doi:10.1038/s41585-023-00793-4Women in urology: the past (Source: Nature Reviews Urology)
Source: Nature Reviews Urology - June 13, 2023 Category: Urology & Nephrology Authors: Louise Stone Source Type: research
Men hold the balance of power
Nature Reviews Urology, Published online: 12 June 2023; doi:10.1038/s41585-023-00790-7Men hold the balance of power (Source: Nature Reviews Urology)
Source: Nature Reviews Urology - June 12, 2023 Category: Urology & Nephrology Authors: Annette Fenner Source Type: research
Women in urology: the future
Nature Reviews Urology, Published online: 12 June 2023; doi:10.1038/s41585-023-00792-5Women in urology: the future (Source: Nature Reviews Urology)
Source: Nature Reviews Urology - June 12, 2023 Category: Urology & Nephrology Authors: Louise Stone Source Type: research
Power up to investigate PrEP
Nature Reviews Urology, Published online: 12 June 2023; doi:10.1038/s41585-023-00791-6Power up to investigate PrEP (Source: Nature Reviews Urology)
Source: Nature Reviews Urology - June 12, 2023 Category: Urology & Nephrology Authors: Annette Fenner Source Type: research
Doxycycline-PEP — novel and promising but needs monitoring
Nature Reviews Urology, Published online: 05 June 2023; doi:10.1038/s41585-023-00788-1Sexually transmitted infections (STIs) remain public health concerns. Doxycycline post-exposure prophylaxis to prevent STIs is a novel promising intervention, which in a new study caused an ∼65% reduction in incident STIs. However, long-term effects on STI prevalence, microbiomes and antimicrobial resistance among STI pathogens, non-STI pathogens and commensals need to be monitored. (Source: Nature Reviews Urology)
Source: Nature Reviews Urology - June 5, 2023 Category: Urology & Nephrology Authors: Magnus Unemo Fabian Yuh Shiong Kong Source Type: research
Current state and future considerations for home uroflowmetry
Nature Reviews Urology, Published online: 30 May 2023; doi:10.1038/s41585-023-00785-4Clinic-based uroflowmetry is limited by a short window of data collection and inefficient data transmission. Obtaining uroflowmetry data in the home setting has the potential for increased data on voiding patterns to inform clinical decision-making. However, integration of this practice depends on optimizing technology and data management. (Source: Nature Reviews Urology)
Source: Nature Reviews Urology - May 30, 2023 Category: Urology & Nephrology Authors: Zoe S. Gan Stephen A. Zderic Source Type: research
Serum tumour markers for testicular cancer recurrence
Nature Reviews Urology, Published online: 30 May 2023; doi:10.1038/s41585-023-00782-7The current serum tumour markers α-fetoprotein, human chorionic gonadotrophin, and lactate dehydrogenase show limited value for testicular cancer relapse detection. A recent study highlights that false-positive elevations in follow-up monitoring are common and, conversely, many patients do not have elevations despite proven relapse. These findings highlight the potential for circulating microRNAs to be used as improved biomarkers for relapse detection. (Source: Nature Reviews Urology)
Source: Nature Reviews Urology - May 30, 2023 Category: Urology & Nephrology Authors: Matthew J. Murray Cinzia G. Scarpini Nicholas Coleman Source Type: research
Urine biomarkers in bladder cancer — current status and future perspectives
Nature Reviews Urology, Published online: 24 May 2023; doi:10.1038/s41585-023-00773-8Urine markers enable non-invasive acquisition of tumour information. The evolution towards multiplex approaches addresses bladder cancer heterogeneity and expands clinical application scenarios for urinary biomarkers. This Review provides a comprehensive overview of current status, limitations and perspectives of various urine markers. (Source: Nature Reviews Urology)
Source: Nature Reviews Urology - May 24, 2023 Category: Urology & Nephrology Authors: Moritz Maas Tilman Todenh öfer Peter C. Black Source Type: research
Sexual health and treatment-related sexual dysfunction in sexual and gender minorities with prostate cancer
Nature Reviews Urology, Published online: 22 May 2023; doi:10.1038/s41585-023-00778-3Effects of prostate cancer treatment in sex and gender minority groups, which include gay and bisexual men, transgender women, or transfeminine people, can include altered sexual function in relation to receptive anal and neovaginal intercourse and changes to patients’ role-in-sex, as well as changes in sexual pleasure related to the loss of the prostate as a source of sexual pleasure. In this Review, the authors discuss the prostate as a sexual organ and consider the effects of prostate cancer treatment in patients from these under-repr...
Source: Nature Reviews Urology - May 22, 2023 Category: Urology & Nephrology Authors: Daniel R. Dickstein Collin R. Edwards Eric J. Lehrer Elizabeth S. Tarras Matthew Gallitto John Sfakianos Matthew D. Galsky Richard Stock Joshua D. Safer B. R. Simon Rosser Deborah C. Marshall Source Type: research
Prostate cancer is not just a man’s concern — the use of PSA screening in transgender women
Nature Reviews Urology, Published online: 22 May 2023; doi:10.1038/s41585-023-00780-9Transgender women remain at risk of prostate cancer and warrant consideration for PSA screening. However, current PSA reference ranges and guidelines are based on data from cisgender men. As these thresholds might be inappropriate in transgender women receiving gender-affirming hormones, we recommend that these patients should undergo screening for prostate cancer at regular intervals and further evaluation for PSA >1 ng/ml or rising PSA. Furthermore patient-centred dialogues should be initiated with patients to ensure awareness of pro...
Source: Nature Reviews Urology - May 22, 2023 Category: Urology & Nephrology Authors: Farnoosh Nik-Ahd Jennifer T. Anger Matthew R. Cooperberg Stephen J. Freedland Source Type: research
Author Correction: Circulating and urinary tumour DNA in urothelial carcinoma — upper tract, lower tract and metastatic disease
Nature Reviews Urology, Published online: 22 May 2023; doi:10.1038/s41585-023-00783-6Author Correction: Circulating and urinary tumour DNA in urothelial carcinoma — upper tract, lower tract and metastatic disease (Source: Nature Reviews Urology)
Source: Nature Reviews Urology - May 22, 2023 Category: Urology & Nephrology Authors: Kyle M. Rose Heather L. Huelster Joshua J. Meeks Bishoy M. Faltas Guru P. Sonpavde Seth P. Lerner Jeffrey S. Ross Philippe E. Spiess G. Daniel Grass Rohit K. Jain Ashish M. Kamat Aram Vosoughi Liang Wang Xuefeng Wang Roger Li Source Type: research
High-intensity theatre (HIT) lists to tackle the elective surgery backlog
Nature Reviews Urology, Published online: 18 May 2023; doi:10.1038/s41585-023-00775-6High intensity theatre (HIT) lists are an efficient and effective measure to tackle elective surgery backlogs without compromising outcomes and safety compared with traditional elective lists. A recent pilot trial in standard and complex urological surgery at a tertiary hospital in the UK proved successful for both the patients and the staff involved. (Source: Nature Reviews Urology)
Source: Nature Reviews Urology - May 18, 2023 Category: Urology & Nephrology Authors: Marc A. Furrer Imran Ahmad Jonathan Noel Kariem El-Boghdadly Ben Challacombe Source Type: research
