Pembrolizumab plus enfortumab vedotin in urothelial cancer
Nature Reviews Urology, Published online: 24 January 2024; doi:10.1038/s41585-024-00858-yThe combination of pembrolizumab and enfortumab vedotin shows promise as a first-line therapy for advanced urothelial carcinoma. Enfortumab vedotin targets nectin-4, in turn enhancing T cell and natural killer cell activity, inhibiting immunosuppressive pathways and impeding tumour evasion. This synergy with pembrolizumab shows potential in enhancing immunotherapy for these patients. (Source: Nature Reviews Urology)
Source: Nature Reviews Urology - January 24, 2024 Category: Urology & Nephrology Authors: Matteo Santoni Hideki Takeshita Francesco Massari Aristotelis Bamias Linda Cerbone Ondrej Fiala Veronica Mollica Sebastiano Buti Angela Santoni Joaquim Bellmunt Source Type: research
Sperm activity affected by endometriosis
Nature Reviews Urology, Published online: 22 January 2024; doi:10.1038/s41585-024-00855-1Sperm activity affected by endometriosis (Source: Nature Reviews Urology)
Source: Nature Reviews Urology - January 22, 2024 Category: Urology & Nephrology Authors: Annette Fenner Source Type: research
A clinical overview of people living with HIV and genitourinary cancer care
Nature Reviews Urology, Published online: 18 January 2024; doi:10.1038/s41585-023-00846-8Antiretroviral therapy means that people living with HIV (PLWH) now often have a long life expectancy. However, their risk of developing cancer — most notably virus-related cancers — has been increasing. In this Review, the authors discuss the risk of genitourinary cancers in PLWH, the inequity of health care access and consider how including PLWH in ongoing cancer trials can help to improve cancer care for this population. (Source: Nature Reviews Urology)
Source: Nature Reviews Urology - January 18, 2024 Category: Urology & Nephrology Authors: Chalairat Suk-Ouichai Anna E. Coghill Matthew B. Schabath Julian A. Sanchez Jad Chahoud Andrea Necchi Anna R. Giuliano Philippe E. Spiess Source Type: research
Focusing on male infertility
Nature Reviews Urology, Published online: 16 January 2024; doi:10.1038/s41585-024-00856-0The burden of male infertility is often unrecognized and its causes are poorly understood. Efforts to increase awareness and understanding are being undertaken to improve fertility outcomes and overall health for affected men. (Source: Nature Reviews Urology)
Source: Nature Reviews Urology - January 16, 2024 Category: Urology & Nephrology Source Type: research
Effect of bariatric surgery on sexual function
Nature Reviews Urology, Published online: 16 January 2024; doi:10.1038/s41585-024-00852-4Effect of bariatric surgery on sexual function (Source: Nature Reviews Urology)
Source: Nature Reviews Urology - January 16, 2024 Category: Urology & Nephrology Authors: Maria Chiara Masone Source Type: research
Gut microbiome’s effect on immunotherapy response
Nature Reviews Urology, Published online: 16 January 2024; doi:10.1038/s41585-024-00854-2Gut microbiome’s effect on immunotherapy response (Source: Nature Reviews Urology)
Source: Nature Reviews Urology - January 16, 2024 Category: Urology & Nephrology Authors: Maria Chiara Masone Source Type: research
Urinoids — a new tool to study bladder cancer
Nature Reviews Urology, Published online: 16 January 2024; doi:10.1038/s41585-024-00853-3Urinoids — a new tool to study bladder cancer (Source: Nature Reviews Urology)
Source: Nature Reviews Urology - January 16, 2024 Category: Urology & Nephrology Authors: Maria Chiara Masone Source Type: research
Being a non-native English speaker in science and medicine
Nature Reviews Urology, Published online: 15 January 2024; doi:10.1038/s41585-023-00839-7The use of English language as the official language in science had an undoubtable role in moving science forward but posed an extra challenge for people whose first language is not English. In this Viewpoint, six non-Native English speakers share their experience as academics, clinicians, researchers and editors who carry out the core tasks of their jobs in a second language, and suggest potential solutions to help overcome issues associated with a linguistic barrier. Their stories show the substantial challenges that non-native Engli...
Source: Nature Reviews Urology - January 15, 2024 Category: Urology & Nephrology Authors: Sigrid V. Carlsson Sandro C. Esteves Elisabeth Grobet-Jeandin Maria Chiara Masone Maria J. Ribal Yao Zhu Source Type: research
The effect of red blood cell disorders on male fertility and reproductive health
Nature Reviews Urology, Published online: 03 January 2024; doi:10.1038/s41585-023-00838-8Haemoglobinopathies, systemic iron imbalances, bone marrow failure syndromes and nutritional deficiencies causing abnormalities in red blood cell physiology have been associated with male infertility. In this Review, the authors explore the effects of erythrocyte disorders and their treatment on male reproductive health. (Source: Nature Reviews Urology)
Source: Nature Reviews Urology - January 3, 2024 Category: Urology & Nephrology Authors: Bryan D. Naelitz Prajit S. Khooblall Neel V. Parekh Sarah C. Vij Seth J. Rotz Scott D. Lundy Source Type: research
Shared decision-making before prostate cancer screening decisions
Nature Reviews Urology, Published online: 02 January 2024; doi:10.1038/s41585-023-00840-0In this Review, the authors discuss shared decision-making for prostate cancer screening in terms of definition, prevalence and methods, including decision aids. Facilitators and barriers to shared decision-making are also discussed. (Source: Nature Reviews Urology)
Source: Nature Reviews Urology - January 2, 2024 Category: Urology & Nephrology Authors: Kelly R. Pekala Daniela K. Shill Mia Austria Aisha T. Langford Stacy Loeb Sigrid V. Carlsson Source Type: research
Intratumoural immunotherapy plus focal thermal ablation for localized prostate cancer
Nature Reviews Urology, Published online: 19 December 2023; doi:10.1038/s41585-023-00834-yIn this Review, the authors examine the potential synergy between thermal ablation and intratumoural immunotherapy in treating localized prostate cancer. This combination could transform the traditionally cold immunological landscape of prostate cancer into a hot one, enhancing treatment efficacy. (Source: Nature Reviews Urology)
Source: Nature Reviews Urology - December 19, 2023 Category: Urology & Nephrology Authors: Denis S éguier Eric S. Adams Srinath Kotamarti Vincent D ’Anniballe Zoe D. Michael Sriram Deivasigamani Jonathan Olivier Arnauld Villers Christopher Hoimes Thomas J. Polascik Source Type: research
Molecular mechanisms of cellular dysfunction in testes from men with non-obstructive azoospermia
Nature Reviews Urology, Published online: 18 December 2023; doi:10.1038/s41585-023-00837-9Understanding the cell-type-specific mechanisms of cellular dysfunction is necessary to develop precision medicine strategies that promote regeneration of spermatogenesis. In this Review, the authors discuss mechanisms of cellular dysfunction that have been elucidated in non-obstructive azoospermia testicular cells, in both somatic cells and germ cells, and consider how identifying modulators of cellular transcription and translation will be key for future research. (Source: Nature Reviews Urology)
Source: Nature Reviews Urology - December 18, 2023 Category: Urology & Nephrology Authors: Arina Piechka Sydney Sparanese Luke Witherspoon Faraz Hach Ryan Flannigan Source Type: research
Mechanical characteristics of the ureter and clinical implications
Nature Reviews Urology, Published online: 15 December 2023; doi:10.1038/s41585-023-00831-1The ureter has mechanical properties that vary along the anatomical length and change with age. In this Review, the authors provide an overview of ureter properties and discuss how understanding the mechanical forces that the ureter is exposed to during clinical interventions can be leveraged to improve surgical outcomes. (Source: Nature Reviews Urology)
Source: Nature Reviews Urology - December 15, 2023 Category: Urology & Nephrology Authors: Sorcha O ’Meara Eoghan M. Cunnane Stefanie M. Croghan Connor V. Cunnane Michael T. Walsh Fergal J. O ’Brien Niall F. Davis Source Type: research
AUC 23 — top-notch urology in a tropical paradise
Nature Reviews Urology, Published online: 14 December 2023; doi:10.1038/s41585-023-00844-wAUC 23 — top-notch urology in a tropical paradise (Source: Nature Reviews Urology)
Source: Nature Reviews Urology - December 14, 2023 Category: Urology & Nephrology Authors: Maria Chiara Masone Source Type: research
Human-relevant urothelial model provides insight into infection strategies and host response
Nature Reviews Urology, Published online: 07 December 2023; doi:10.1038/s41585-023-00843-xHuman-relevant urothelial model provides insight into infection strategies and host response (Source: Nature Reviews Urology)
Source: Nature Reviews Urology - December 7, 2023 Category: Urology & Nephrology Authors: Louise Lloyd Source Type: research
