Intravesical ICIs to reduce toxicity in NMIBC
Nature Reviews Urology, Published online: 31 October 2022; doi:10.1038/s41585-022-00674-2Intravesical ICIs to reduce toxicity in NMIBC (Source: Nature Reviews Urology)
Source: Nature Reviews Urology - October 31, 2022 Category: Urology & Nephrology Authors: Maria Chiara Masone Source Type: research
WGC in patients with localized prostate cancer
Nature Reviews Urology, Published online: 31 October 2022; doi:10.1038/s41585-022-00673-3WGC in patients with localized prostate cancer (Source: Nature Reviews Urology)
Source: Nature Reviews Urology - October 31, 2022 Category: Urology & Nephrology Authors: Maria Chiara Masone Source Type: research
Augmented reality to locate iliac plaques in RAKT
Nature Reviews Urology, Published online: 31 October 2022; doi:10.1038/s41585-022-00675-1Augmented reality to locate iliac plaques in RAKT (Source: Nature Reviews Urology)
Source: Nature Reviews Urology - October 31, 2022 Category: Urology & Nephrology Authors: Maria Chiara Masone Source Type: research
Understanding and managing the cardiovascular risks of androgen deprivation therapy for prostate cancer
Nature Reviews Urology, Published online: 24 October 2022; doi:10.1038/s41585-022-00671-5Androgen deprivation therapy potentiates cardiovascular morbidity and mortality, which is the most common cause of non-cancer-related death in patients with prostate cancer. Whether the mode of testosterone suppression affects the risk of cardiovascular adverse events is unclear, especially as the 2021 PRONOUNCE trial — which aimed to compare the cardiovascular risks of gonadotropin-releasing hormone (GnRH) antagonists with GnRH agonists — was prematurely terminated. (Source: Nature Reviews Urology)
Source: Nature Reviews Urology - October 24, 2022 Category: Urology & Nephrology Authors: Kerem Atalar Prabhakar Rajan Source Type: research
PBRM1, SETD2 and BAP1 — the trinity of 3p in clear cell renal cell carcinoma
Nature Reviews Urology, Published online: 17 October 2022; doi:10.1038/s41585-022-00659-1In this Perspective, the authors provide an overview of the roles of three genes, PBRM1, SETD2 and BAP1, which are commonly lost with chromosome 3p deletion in patients with clear cell renal cell carcinoma (ccRCC). The authors discuss the implication of these genes in cancer-related pathways and how an improved understanding of these mechanisms might help to develop potential new therapies in ccRCC. (Source: Nature Reviews Urology)
Source: Nature Reviews Urology - October 17, 2022 Category: Urology & Nephrology Authors: Joseph Walton Keith Lawson Panagiotis Prinos Antonio Finelli Cheryl Arrowsmith Laurie Ailles Source Type: research
The composition and influence of the gut mycobiome in bladder cancer
Nature Reviews Urology, Published online: 12 October 2022; doi:10.1038/s41585-022-00668-0The composition and influence of the gut mycobiome in bladder cancer (Source: Nature Reviews Urology)
Source: Nature Reviews Urology - October 12, 2022 Category: Urology & Nephrology Authors: Louise Stone Source Type: research
UPEC-mediated alteration of host mitochondrial function — a survival strategy
Nature Reviews Urology, Published online: 04 October 2022; doi:10.1038/s41585-022-00662-6UPEC-mediated alteration of host mitochondrial function — a survival strategy (Source: Nature Reviews Urology)
Source: Nature Reviews Urology - October 4, 2022 Category: Urology & Nephrology Authors: Maria Chiara Masone Source Type: research
Long-acting ART in poor viral suppression
Nature Reviews Urology, Published online: 04 October 2022; doi:10.1038/s41585-022-00665-3Long-acting ART in poor viral suppression (Source: Nature Reviews Urology)
Source: Nature Reviews Urology - October 4, 2022 Category: Urology & Nephrology Authors: Annette Fenner Source Type: research
ARNEO: neoadjuvant degarelix + apalutamide before surgery for high-risk prostate cancer
Nature Reviews Urology, Published online: 04 October 2022; doi:10.1038/s41585-022-00664-4ARNEO: neoadjuvant degarelix + apalutamide before surgery for high-risk prostate cancer (Source: Nature Reviews Urology)
Source: Nature Reviews Urology - October 4, 2022 Category: Urology & Nephrology Authors: Annette Fenner Source Type: research
Identifying undifferentiated spermatogonia in patients with Klinefelter syndrome
Nature Reviews Urology, Published online: 04 October 2022; doi:10.1038/s41585-022-00663-5Identifying undifferentiated spermatogonia in patients with Klinefelter syndrome (Source: Nature Reviews Urology)
Source: Nature Reviews Urology - October 4, 2022 Category: Urology & Nephrology Authors: Annette Fenner Source Type: research
Fatty acid metabolism reprogramming in ccRCC: mechanisms and potential targets
Nature Reviews Urology, Published online: 03 October 2022; doi:10.1038/s41585-022-00654-6Altered lipid metabolism is a visually obvious, distinguishing feature of clear-cell renal cell carcinoma. In this Perspective the authors describe the molecular mechanisms driving fatty acid accumulation and discuss potential therapeutic targets in this disease. (Source: Nature Reviews Urology)
Source: Nature Reviews Urology - October 3, 2022 Category: Urology & Nephrology Authors: Sze Kiat Tan Helen Y. Hougen Jaime R. Merchan Mark L. Gonzalgo Scott M. Welford Source Type: research
Is it time to rethink the current patient-reported outcome measures?
Nature Reviews Urology, Published online: 03 October 2022; doi:10.1038/s41585-022-00661-7Across health care, clinicians are increasingly using patient-reported outcome measures (PROMs) to give a voice to patients and to help standardize the assessment of patients for comparison purposes. With this increasing use, the limitations of these PROMs should not be underestimated within the diverse population that we treat. (Source: Nature Reviews Urology)
Source: Nature Reviews Urology - October 3, 2022 Category: Urology & Nephrology Authors: Findlay MacAskill Arun Sahai Majed Shabbir Prokar Dasgupta Paul Cathcart Amy Sandher Karen Briggs Christian Brown Jonathan Noel Ben Challacombe Rick Popert Raveen Sandher Claire Taylor Sachin Malde Tet Yap Source Type: research
The endoplasmic reticulum stress response in prostate cancer
Nature Reviews Urology, Published online: 27 September 2022; doi:10.1038/s41585-022-00649-3The unfolded protein response has an important role in prostate cancer tumorigenesis. Here, the authors discuss its involvement in prostate cancer development and progression, interactions with androgen receptor signalling, and the therapeutic implications for the treatment of metastatic disease. (Source: Nature Reviews Urology)
Source: Nature Reviews Urology - September 27, 2022 Category: Urology & Nephrology Authors: Claire M. de la Calle Kevin Shee Heiko Yang Peter E. Lonergan Hao G. Nguyen Source Type: research
Quality checkpoints in the MRI-directed prostate cancer diagnostic pathway
Nature Reviews Urology, Published online: 27 September 2022; doi:10.1038/s41585-022-00648-4In this Review, the authors analyse all the steps of the multiparametric MRI-guided prostate cancer diagnostic pathway, focusing on quality assurance systems to minimize variation in performance and discussing quality control measures to assess and mitigate poor quality throughout the process. (Source: Nature Reviews Urology)
Source: Nature Reviews Urology - September 27, 2022 Category: Urology & Nephrology Authors: Tristan Barrett Maarten de Rooij Francesco Giganti Clare Allen Jelle O. Barentsz Anwar R. Padhani Source Type: research
Mechanisms of the intestinal and urinary microbiome in kidney stone disease
Nature Reviews Urology, Published online: 20 September 2022; doi:10.1038/s41585-022-00647-5Evidence has suggested that the intestinal microbiome might have a role in maintaining oxalate homeostasis and kidney stone disease and that the urinary microbiome might also influence the induction of crystal formation and stone growth directly in the kidney. In this Review, the authors discuss the mechanisms by which these microbial populations contribute to stone disease and how they might be therapeutically targeted. (Source: Nature Reviews Urology)
Source: Nature Reviews Urology - September 20, 2022 Category: Urology & Nephrology Authors: Aaron W. Miller Kristina L. Penniston Kate Fitzpatrick Jos é Agudelo Gregory Tasian Dirk Lange Source Type: research
