Male infertility and somatic health — insights into lipid damage as a mechanistic link
Nature Reviews Urology, Published online: 13 September 2022; doi:10.1038/s41585-022-00640-yAn association between infertility and poor somatic health exists, and infertility could be used as an indicator of a future pathological condition. However, the bidirectional relationship between infertility and poor health needs to be elucidated. In this Perspective, the authors discuss current advances and gaps in this area, focusing on lipid peroxidation and oxidative damage as potential molecular links between infertility and somatic health. (Source: Nature Reviews Urology)
Source: Nature Reviews Urology - September 13, 2022 Category: Urology & Nephrology Authors: Nathan D. Burke Brett Nixon Shaun D. Roman John E. Schjenken Jessica L. H. Walters R. John Aitken Elizabeth G. Bromfield Source Type: research
What is fuelling the monkeypox outbreak?
Nature Reviews Urology, Published online: 12 September 2022; doi:10.1038/s41585-022-00658-2What is fuelling the monkeypox outbreak? (Source: Nature Reviews Urology)
Source: Nature Reviews Urology - September 12, 2022 Category: Urology & Nephrology Authors: Annette Fenner Source Type: research
Time for women-centred gynaecology
Nature Reviews Urology, Published online: 09 September 2022; doi:10.1038/s41585-022-00656-4Although gynaecology is a specialty responsible for women’s health, the field was historically male-dominated and its science remains biased towards male perceptions of women’s health. In light of the changing social climate in our society and the changing gender composition of the specialty, a number of steps can be taken to make gynaecology more women-centred. (Source: Nature Reviews Urology)
Source: Nature Reviews Urology - September 9, 2022 Category: Urology & Nephrology Authors: Netta Avnoon Source Type: research
Secondary kidney stones — remove or leave?
Nature Reviews Urology, Published online: 09 September 2022; doi:10.1038/s41585-022-00657-3Secondary kidney stones — remove or leave? (Source: Nature Reviews Urology)
Source: Nature Reviews Urology - September 9, 2022 Category: Urology & Nephrology Authors: Maria Chiara Masone Source Type: research
A great gathering at the 4th Clinical and Scientific Advances in UTI conference
Nature Reviews Urology, Published online: 08 September 2022; doi:10.1038/s41585-022-00655-5A great gathering at the 4th Clinical and Scientific Advances in UTI conference (Source: Nature Reviews Urology)
Source: Nature Reviews Urology - September 8, 2022 Category: Urology & Nephrology Authors: Louise Stone Source Type: research
Purine nucleoside phosphorylase as a target to treat age-associated lower urinary tract dysfunction
Nature Reviews Urology, Published online: 07 September 2022; doi:10.1038/s41585-022-00642-wLower urinary tract disorders (LUTDs) are common in the elderly, owing to age-related dysfunction of the lower urinary tract (LUT). An endogenous inhibitor of purine nucleoside phosphorylase, 8-aminoguanine, has been shown to reverse the effects of ageing on LUT biochemistry, structure and function, offering a novel potential treatment for LUTDs. (Source: Nature Reviews Urology)
Source: Nature Reviews Urology - September 7, 2022 Category: Urology & Nephrology Authors: Lori A. Birder Edwin K. Jackson Source Type: research
Transitional care in urology: the road to independence
Nature Reviews Urology, Published online: 06 September 2022; doi:10.1038/s41585-022-00653-7Transition from child-centred to adult-centred care is a crucial step for patients with a congenital urological disease. The aims are clear: preserving kidney function, continence, sexuality and fertility. No universal model for this process has been defined, but, while research continues, attention to individual patient’s needs will ensure the best results. (Source: Nature Reviews Urology)
Source: Nature Reviews Urology - September 6, 2022 Category: Urology & Nephrology Authors: Alessandro Morlacco Marta Bianco Fabrizio Dal Moro Source Type: research
The shifting treatment paradigm of metastatic renal cell carcinoma
Nature Reviews Urology, Published online: 05 September 2022; doi:10.1038/s41585-022-00651-9The treatment landscape of renal cell carcinoma is rapidly evolving, especially with the introduction and approval of immune checkpoint inhibitor combination therapies. Clinical trial data show substantial improvements in patient outcomes, and now results in the real-world setting support the use of these combinations. (Source: Nature Reviews Urology)
Source: Nature Reviews Urology - September 5, 2022 Category: Urology & Nephrology Authors: Yasser Ged Mark C. Markowski Nirmish Singla Steven P. Rowe Source Type: research
Nature versus nurture contribution to prostate cancer risk
Nature Reviews Urology, Published online: 30 August 2022; doi:10.1038/s41585-022-00650-wGenetics has a role in predisposition towards prostate cancer, and an accurate prediction of prostate cancer risk can be made using polygenic risk scores. New evidence suggests that this risk is modifiable through lifestyle changes, but only in men at a high genetic risk of developing prostate cancer. (Source: Nature Reviews Urology)
Source: Nature Reviews Urology - August 30, 2022 Category: Urology & Nephrology Authors: Stephen J. Freedland Nadine (Adriana) Friedrich Source Type: research
Biomarkers of disease recurrence in stage I testicular germ cell tumours
Nature Reviews Urology, Published online: 26 August 2022; doi:10.1038/s41585-022-00624-yStage I testicular germ cell tumour is restricted to the testicle and can be mostly cured by orchiectomy; however, many patients experience tumour relapse. In this Review, the authors describe advantages and limitations of the currently available predictive biomarkers of relapse in germ cell tumours, and discuss the need to identify new biomarkers to avoid patient overtreatment. (Source: Nature Reviews Urology)
Source: Nature Reviews Urology - August 26, 2022 Category: Urology & Nephrology Authors: Peter Lesko Michal Chovanec Michal Mego Source Type: research
Mapping gonadogenesis in time and space
Nature Reviews Urology, Published online: 26 August 2022; doi:10.1038/s41585-022-00652-8Mapping gonadogenesis in time and space (Source: Nature Reviews Urology)
Source: Nature Reviews Urology - August 26, 2022 Category: Urology & Nephrology Authors: Louise Stone Source Type: research
Current and emerging treatment options for premature ejaculation
Nature Reviews Urology, Published online: 25 August 2022; doi:10.1038/s41585-022-00639-5Premature ejaculation is a male disorder causing distress, bother, frustration and/or avoidance of sexual intimacy. Currently available therapies are not lasting and only mildly effective. In this Review, the authors summarize currently available approved and off-label treatments for premature ejaculation, and comprehensively discuss emerging therapeutic options. (Source: Nature Reviews Urology)
Source: Nature Reviews Urology - August 25, 2022 Category: Urology & Nephrology Authors: Murat Gul Kadir Bocu Ege Can Serefoglu Source Type: research
Spatiotemporal trends in human semen quality
Nature Reviews Urology, Published online: 17 August 2022; doi:10.1038/s41585-022-00626-wSeveral studies over the past few decades have suggested that sperm quality varies by geographical region and might be subject to a temporal decline worldwide. However, the data supporting these conclusions have come from studies of various methodologies and heterogeneous populations, making them unreliable. In this in-depth Review, Chevrier and colleagues discuss the data surrounding discussion of spatiotemporal trends in semen parameters and consider how these trends and the factors promoting them interact. (Source: Nature Reviews Urology)
Source: Nature Reviews Urology - August 17, 2022 Category: Urology & Nephrology Authors: Jacques Auger Florence Eustache C écile Chevrier Bernard J égou Source Type: research
Serum PSA-based early detection of prostate cancer in Europe and globally: past, present and future
Nature Reviews Urology, Published online: 16 August 2022; doi:10.1038/s41585-022-00638-6In this Perspective, the authors discuss the past, present and future of PSA screening for the early detection of aggressive prostate cancer and propose a way forward for the rational use of PSA testing as part of a risk-adapted screening strategy. (Source: Nature Reviews Urology)
Source: Nature Reviews Urology - August 16, 2022 Category: Urology & Nephrology Authors: Hendrik Van Poppel Tit Albreht Partha Basu Ren ée Hogenhout Sarah Collen Monique Roobol Source Type: research
Potential role of oxidative stress in the pathogenesis of diabetic bladder dysfunction
Nature Reviews Urology, Published online: 16 August 2022; doi:10.1038/s41585-022-00621-1Diabetic bladder dysfunction (DBD) is a common complication of diabetes. Hyperglycaemia-induced oxidative stress is thought to mediate functional changes in organs and tissues affected by DBD. In this Review, the authors provide an overview of mechanisms and consequences of oxidative stress, focusing on the role of diabetes-induced oxidative stress in generating dysfunctions at the level of the urothelium, smooth muscle contractility and nerve structures involved in DBD pathogenesis. (Source: Nature Reviews Urology)
Source: Nature Reviews Urology - August 16, 2022 Category: Urology & Nephrology Authors: Qi-Xiang Song Yi Sun Kangli Deng Jin-Yi Mei Christopher J. Chermansky Margot S. Damaser Source Type: research
