FOXA2–KIT-driven lineage plasticity in NEPC
Nature Reviews Urology, Published online: 07 December 2022; doi:10.1038/s41585-022-00694-yFOXA2–KIT-driven lineage plasticity in NEPC (Source: Nature Reviews Urology)
Source: Nature Reviews Urology - December 7, 2022 Category: Urology & Nephrology Authors: Maria Chiara Masone Source Type: research
A non-invasive assay for UTUC diagnosis
Nature Reviews Urology, Published online: 07 December 2022; doi:10.1038/s41585-022-00696-wA non-invasive assay for UTUC diagnosis (Source: Nature Reviews Urology)
Source: Nature Reviews Urology - December 7, 2022 Category: Urology & Nephrology Authors: Maria Chiara Masone Source Type: research
Using PSMA imaging for prognostication in localized and advanced prostate cancer
Nature Reviews Urology, Published online: 06 December 2022; doi:10.1038/s41585-022-00670-6In this Review, the authors discuss the novel concept of the prognostic role of prostate-specific membrane antigen (PSMA)–PET across all prostate cancer disease states in the context of established prognostic tools and describe the future directions of research on the prognostic value of PSMA–PET. (Source: Nature Reviews Urology)
Source: Nature Reviews Urology - December 6, 2022 Category: Urology & Nephrology Authors: Matthew J. Roberts Tobias Maurer Marlon Perera Matthias Eiber Thomas A. Hope Piet Ost Shankar Siva Michael S. Hofman Declan G. Murphy Louise Emmett Wolfgang P. Fendler Source Type: research
Transgender women with prostate cancer are under-represented in national cancer registries
Nature Reviews Urology, Published online: 06 December 2022; doi:10.1038/s41585-022-00688-wTransgender women are extensively under-represented in national cancer databases. Improved representation is urgently needed to bridge the evidence gap for this growing population and to inform prostate cancer epidemiology and professional guidelines. (Source: Nature Reviews Urology)
Source: Nature Reviews Urology - December 6, 2022 Category: Urology & Nephrology Authors: Elie Kaplan-Marans Tenny R. Zhang Lee C. Zhao Jim C. Hu Source Type: research
Does immune cell exhaustion lie at the heart of BCG-unresponsive disease?
Nature Reviews Urology, Published online: 01 December 2022; doi:10.1038/s41585-022-00687-xImmune system activation is necessary for BCG-mediated tumour immunity in non-muscle-invasive bladder cancer. However, mounting evidence supports the notion that dysfunctional activation, in the form of immune exhaustion, might contribute to BCG failure. Thus, an exhaustion signature, arising in treated tumours, could act as a predictive marker for BCG therapy. (Source: Nature Reviews Urology)
Source: Nature Reviews Urology - December 1, 2022 Category: Urology & Nephrology Authors: Molly A. Ingersoll Source Type: research
Experimental in vitro, ex vivo and in vivo models in prostate cancer research
Nature Reviews Urology, Published online: 30 November 2022; doi:10.1038/s41585-022-00677-zIn this Review, the authors provide a comprehensive overview of various in vitro, ex vivo and in vivo models of prostate cancer and discuss their respective advantages and limitations in the context of current needs and challenges in prostate cancer research and therapy. (Source: Nature Reviews Urology)
Source: Nature Reviews Urology - November 30, 2022 Category: Urology & Nephrology Authors: Verena Sailer Gunhild von Amsberg Stefan Duensing Jutta Kirfel Verena Lieb Eric Metzger Anne Offermann Klaus Pantel Roland Schuele Helge Taubert Sven Wach Sven Perner Stefan Werner Achim Aigner Source Type: research
Partial gland cryoablation for prostate cancer — where are we?
Nature Reviews Urology, Published online: 25 November 2022; doi:10.1038/s41585-022-00685-zThe treatment landscape for localized prostate cancer is rapidly evolving to achieve oncological disease control, simultaneously preserving gastrointestinal and genitourinary function. Focal therapy using cryoablation is an emerging treatment for prostate cancer. Short-term and intermediate-term clinical data on focal cryoablation therapy in prostate cancer have shown promising oncological and functional outcomes. (Source: Nature Reviews Urology)
Source: Nature Reviews Urology - November 25, 2022 Category: Urology & Nephrology Authors: Wei Phin Tan James S. Wysock Herbert Lepor Source Type: research
Relationships between holmium laser enucleation of the prostate and prostate cancer
Nature Reviews Urology, Published online: 23 November 2022; doi:10.1038/s41585-022-00678-yIn this Perspective, the authors present clinical scenarios in which prostate hyperplasia and prostate cancer overlap, with a specific focus on holmium laser enucleation of the prostate (HoLEP). Variables associated with incidental prostate cancer detection at HoLEP and prostate cancer development after HoLEP, as well as the role of HoLEP in patients with biopsy-proven prostate cancer, are also discussed. (Source: Nature Reviews Urology)
Source: Nature Reviews Urology - November 23, 2022 Category: Urology & Nephrology Authors: Matthew S. Lee Mark A. Assmus Jenny Guo Mohammad R. Siddiqui Ashley E. Ross Amy E. Krambeck Source Type: research
Prognostic and predictive biomarkers for immunotherapy in advanced renal cell carcinoma
Nature Reviews Urology, Published online: 21 November 2022; doi:10.1038/s41585-022-00676-0The approval of immunotherapy agents to treat patients with metastatic renal cell carcinoma revolutionized the therapeutic landscape for this disease, but a large number of patients still do not experience objective and durable response, and biomarkers to identify response to immunotherapy are urgently needed. In this Review, the authors describe strength and limitations of currently available prognostic and predictive biomarkers in metastatic renal cell carcinoma and discuss emerging promising biomarkers that deserve further investig...
Source: Nature Reviews Urology - November 21, 2022 Category: Urology & Nephrology Authors: Matteo Rosellini Andrea Marchetti Veronica Mollica Alessandro Rizzo Matteo Santoni Francesco Massari Source Type: research
Can PROMs improve racial equity in outcomes after prostatectomy?
Nature Reviews Urology, Published online: 21 November 2022; doi:10.1038/s41585-022-00682-2Growing evidence suggests that urinary and sexual functional outcomes after radical prostatectomy for prostate cancer differ based on race, with Black men experiencing worse outcomes. Alongside efforts to improve quality and equity, incorporating patient-reported outcomes measures into patient care could improve equity in treatment outcomes for men with prostate cancer. (Source: Nature Reviews Urology)
Source: Nature Reviews Urology - November 21, 2022 Category: Urology & Nephrology Authors: Alexander P. Cole Mara Koelker Jonathan Makanjuola Caroline M. Moore Source Type: research
Adjuvant therapy options in renal cell carcinoma — targeting the metastatic cascade
Nature Reviews Urology, Published online: 11 November 2022; doi:10.1038/s41585-022-00666-2Adjuvant therapies in renal cell carcinoma (RCC) disrupt multiple steps of the metastatic cascade. Results from clinical trials to assess adjuvant treatment with immunotherapeutic agents in patients with resected clear cell RCC were promising, but the utility of tyrosine kinase inhibitors in this setting was not clearly shown. In this Perspective, the authors provide an overview of completed and ongoing clinical trials for adjuvant treatment of RCC, highlighting future directions and challenges in the field. (Source: Nature Reviews Urology)
Source: Nature Reviews Urology - November 11, 2022 Category: Urology & Nephrology Authors: Kelly N. Fitzgerald Robert J. Motzer Chung-Han Lee Source Type: research
COVID can’t kill CopMich collaboration
Nature Reviews Urology, Published online: 11 November 2022; doi:10.1038/s41585-022-00681-3COVID can’t kill CopMich collaboration (Source: Nature Reviews Urology)
Source: Nature Reviews Urology - November 11, 2022 Category: Urology & Nephrology Authors: Annette Fenner Source Type: research
Microfluidics facilitating the use of small extracellular vesicles in innovative approaches to male infertility
Nature Reviews Urology, Published online: 08 November 2022; doi:10.1038/s41585-022-00660-8Here, Goss et al. explore the diagnostic potential of male reproductive small extracellular vesicles and the practical approaches of implementing point-of-need and multianalyte diagnostics in infertility treatment, detailing microfluidic small extracellular vesicle isolation and analysis as an accessible and effective approach to achieving this outcome. (Source: Nature Reviews Urology)
Source: Nature Reviews Urology - November 8, 2022 Category: Urology & Nephrology Authors: Dale M. Goss Steven A. Vasilescu Gavin Sacks David K. Gardner Majid E. Warkiani Source Type: research
USPSTF reaffirms recommendations on screening for syphilis infection
Nature Reviews Urology, Published online: 08 November 2022; doi:10.1038/s41585-022-00679-xUSPSTF reaffirms recommendations on screening for syphilis infection (Source: Nature Reviews Urology)
Source: Nature Reviews Urology - November 8, 2022 Category: Urology & Nephrology Authors: Louise Stone Source Type: research
Inheritance in overactive bladder syndrome
Nature Reviews Urology, Published online: 07 November 2022; doi:10.1038/s41585-022-00667-1Despite the high prevalence of overactive bladder (OAB) syndrome, its pathophysiology remains poorly understood. Twin studies offer a unique opportunity for studying the genetics of this disorder, but trials are limited by heterogeneous patient populations. Improved understanding of genetic factors in OAB will be vital to developing targeted management. (Source: Nature Reviews Urology)
Source: Nature Reviews Urology - November 7, 2022 Category: Urology & Nephrology Authors: Nicholas Raison Sachin Malde Arun Sahai Source Type: research
