Development, Characterization, and Radiation Dosimetry Studies of 18F-BMS-986229, a 18F-Labeled PD-L1 Macrocyclic Peptide PET Tracer
Conclusion18F-BMS-986229 has been preclinically characterized and exhibits high target specificity, low background uptake, and a short blood half-life supportive of same day imaging in the clinic. As the PET tracer,18F-BMS-986229 shows promise in the quantification of PD-L1 expression, and its use in monitoring longitudinal changes in patients may provide insights into PD-1:PD-L1 immuno-therapy treatment outcomes. (Source: Molecular Imaging and Biology)
Source: Molecular Imaging and Biology - December 20, 2023 Category: Molecular Biology Source Type: research
Multi-channel Small Animal Drug Metabolism Real-Time Monitoring Fluorescence System
ConclusionThe real-time continuous monitoring and data collection of the drug metabolism in the plasma of living small animals and the important organs such as kidney, liver, and spleen were realized. The research and development of new drugs and clinical research have higher practical value. (Source: Molecular Imaging and Biology)
Source: Molecular Imaging and Biology - December 19, 2023 Category: Molecular Biology Source Type: research
Detection of Intestinal Inflammation by Vascular Adhesion Protein-1-Targeted [68Ga]Ga-DOTA-Siglec-9 Positron Emission Tomography in Murine Models of Inflammatory Bowel Disease
ConclusionsThis study suggests that the VAP-1-targeting [68Ga]Ga-DOTA-Siglec-9 PET tracer is a promising tool for non-invasive imaging of intestinal inflammation. Future studies in patients with IBD and evaluation of the potential value of [68Ga]Ga-DOTA-Siglec-9 in diagnosis and monitoring of the disease are warranted. (Source: Molecular Imaging and Biology)
Source: Molecular Imaging and Biology - December 18, 2023 Category: Molecular Biology Source Type: research
Evaluation and Application of a PET Tracer in Preclinical and Phase 1 Studies to Determine the Brain Biodistribution of Minzasolmin (UCB0599)
ConclusionFollowing positive preclinical results with the N-methyl labeled PET tracer, [11C]minzasolmin was used in the phase 1 study, which demonstrated that minzasolmin readily crossed the blood –brain barrier and was well distributed throughout the brain. Safety and pharmacokinetic findings were consistent with previous early-phase studies (such as UP0077, NCT04875962). (Source: Molecular Imaging and Biology)
Source: Molecular Imaging and Biology - December 18, 2023 Category: Molecular Biology Source Type: research
The Theranostic Optimization of PSMA-GCK01 Does Not Compromise the Imaging Characteristics of [99mTc]Tc-PSMA-GCK01 Compared to Dedicated Diagnostic [99mTc]Tc-EDDA/HYNIC-iPSMA in Prostate Cancer
ConclusionsThe novel theranostic tracer [99mTc]Tc/[188Re]Re-PSMA-GCK01 demonstrates comparable general imaging characteristic with the reference compound [99mTc]Tc-EDDA/HYNIC-iPSMA. These results pave the way for the PSMA-targeting imaging and theranostic agents for a broader, rather low-cost, generator applied radio-ligand therapy utilization. (Source: Molecular Imaging and Biology)
Source: Molecular Imaging and Biology - December 8, 2023 Category: Molecular Biology Source Type: research
Identification of Optimal Tissue-Marking Dye Color for Pathological Evaluation in Fluorescence Imaging Using IRDye800CW
ConclusionYellow, red, and orange TMDs should be used, and blue and black TMDs should be avoided for evaluating tumor specimens through fluorescence imaging using IRDye800CW. (Source: Molecular Imaging and Biology)
Source: Molecular Imaging and Biology - December 6, 2023 Category: Molecular Biology Source Type: research
Multimodal Imaging Reveals that Sustained Inhibition of HIF-Prolyl Hydroxylases Induces Opposing Effects on Right and Left Ventricular Function in Healthy Rats
ConclusionThese opposing cardiac effects of HIF-PH inhibition warrant further study to both understand the potential negative effects on RV structure and function and investigate the therapeutic potential of increased LV contractility for conditions like heart failure. (Source: Molecular Imaging and Biology)
Source: Molecular Imaging and Biology - December 6, 2023 Category: Molecular Biology Source Type: research
Electron Spin Resonance Probe Incorporation into Bioinks Permits Longitudinal Oxygen Imaging of Bioprinted Constructs
ConclusionsThe feasibility of the cointegration of 4D EPR imaging and 4D bioprinting has been demonstrated. The proof-of-concept experiments, which were conducted using oxygen probes loaded into GelMA, lay the foundation for a broad range of applications, such as bioprinting with many types of bioinks loaded with diverse varieties of molecular spin probes. (Source: Molecular Imaging and Biology)
Source: Molecular Imaging and Biology - December 1, 2023 Category: Molecular Biology Source Type: research
Reprogramming a Doxycycline-Inducible Gene Switch System for Bacteria-Mediated Cancer Therapy
ConclusionsThese results suggest that attenuatedS. typhimurium carrying this novel gene switch system elicited significant therapeutic effects through a single induction triggering and were a potential biotherapeutic agent for tumor therapy. (Source: Molecular Imaging and Biology)
Source: Molecular Imaging and Biology - November 28, 2023 Category: Molecular Biology Source Type: research
The First Human Application of an F-18-Labeled Tryptophan Analog for PET Imaging of Cancer
ConclusionsThe study provides proof-of-principle data for the safety and potential clinical value of18F-FETrp-PET for molecular imaging of human gliomas. (Source: Molecular Imaging and Biology)
Source: Molecular Imaging and Biology - November 27, 2023 Category: Molecular Biology Source Type: research
MIB Guides: Preclinical Radiopharmaceutical Dosimetry
AbstractPreclinical dosimetry is essential for guiding the design of animal radiopharmaceutical biodistribution, imaging, and therapy experiments, evaluating efficacy and/or toxicities in such experiments, ensuring compliance with ethical standards for animal research, and, perhaps most importantly, providing reasonable initial estimates of normal-organ doses in humans, required for clinical translation of new radiopharmaceuticals. This MIB Guide provides a basic protocol for obtaining preclinical dosimetry estimates with organ-level dosimetry software. (Source: Molecular Imaging and Biology)
Source: Molecular Imaging and Biology - November 14, 2023 Category: Molecular Biology Source Type: research
Correction to: Magnetic Particle Imaging-Guided Hyperthermia for Precise Treatment of Cancer: Review, Challenges, and Prospects
(Source: Molecular Imaging and Biology)
Source: Molecular Imaging and Biology - November 10, 2023 Category: Molecular Biology Source Type: research
Physiological Uptake Characteristics of Breast on 68Ga-FAPI-04 PET/CT
AbstractPurposeGallium 68 (68Ga)-labeled fibroblast activation protein inhibitor (FAPI) PET/CT is sensitive on breast cancer staging, but its clinical utility may be limited by the high physiological68Ga-FAPI-04 uptake in normal breast tissue that can obscure primary tumors. The aim of this study was to elucidate the characteristics of physiological68Ga-FAPI-04 uptake in normal breast.ProceduresA total of 143 consecutive women with68Ga-FAPI-04 PET/CT data were reviewed retrospectively. SUVmax, density and thickness of breast, as well as SUVmax of nipple, were measured. Univariate and multivariate regression analyses were u...
Source: Molecular Imaging and Biology - November 9, 2023 Category: Molecular Biology Source Type: research
SOX71, A Biocompatible Succinyl Derivative of the Triarylmethyl Radical OX071 for In Vivo Quantitative Oxygen Mapping Using Electron Paramagnetic Resonance
ConclusionSOX71, a succinylated derivative of OX071 was synthesized, characterized, and applied forin vivo EPR tumor oxygen imaging. SOX71 is highly biocompatible, and shows decreased sensitivity to oxygen and self-relaxation. This first report suggests that SOX71 is superior to OX071 for absolute oxygen mapping under a broad range ofpO2 values. (Source: Molecular Imaging and Biology)
Source: Molecular Imaging and Biology - November 9, 2023 Category: Molecular Biology Source Type: research
Imaging in Type 1 Diabetes, Current Perspectives and Directions
AbstractType 1 diabetes (T1D) is characterized by the autoimmune-mediated attack of insulin-producing beta cells in the pancreas, leading to reliance on exogenous insulin to control a patient ’s blood glucose levels. As progress is being made in understanding the pathophysiology of the disease and how to better develop therapies to treat it, there is an increasing need for monitoring technologies to quantify beta cell mass and function throughout T1D progression and beta cell replaceme nt therapy. Molecular imaging techniques offer a possible solution through both radiologic and non-radiologic means including positron em...
Source: Molecular Imaging and Biology - November 7, 2023 Category: Molecular Biology Source Type: research
