Three-Dimensional Near-Infrared Specimen Mapping Can Identify the Distance from the Tumor to the Surgical Margin During Resection of Pulmonary Ground Glass Opacities
Conclusions3D-NSM rapidly localizes GGOs by fluorescence and detects tumor-positive or close surgical margins. 3D-NSM can accurately quantify the resection margin distance as compared to formal pathology, which allows surgeons to rapidly determine whether sublobar resection margin distances are adequate. (Source: Molecular Imaging and Biology)
Source: Molecular Imaging and Biology - July 13, 2022 Category: Molecular Biology Source Type: research
Clinical-Radiomics Nomogram from T1W, T1CE, and T2FS MRI for Improving Diagnosis of Soft-Tissue Sarcoma
ConclusionThe proposed nomogram may have potential as a noninvasive marker for STS diagnosis. (Source: Molecular Imaging and Biology)
Source: Molecular Imaging and Biology - July 7, 2022 Category: Molecular Biology Source Type: research
Evaluation of 18F-flutemetamol amyloid PET image analysis parameters on the effect of verubecestat on brain amlyoid load in Alzheimer ’s disease
ConclusionsTreatment-related18F-flutemetamol longitudinal changes in AD clinical trials can be quantified using a subcortical white matter reference region without PVC.Clinical trial registration: clinicaltrials.gov NCT01739348. (Source: Molecular Imaging and Biology)
Source: Molecular Imaging and Biology - July 7, 2022 Category: Molecular Biology Source Type: research
Head-to-Head Comparison of [68 Ga]Ga-FAPI-46-PET/CT and [18F]F-FDG-PET/CT for Radiotherapy Planning in Head and Neck Cancer
ConclusionWe demonstrate that [68 Ga]Ga-FAPI-46 -PET/CT is useful for detecting tumor lesions in patients with HNCs. There is now a need for prospective randomized studies to confirm the role of [68 Ga]Ga-FAPI-46 PET/CT in relation to [18F]F-FDG PET/CT in HNCs and to evaluate its impact on clinical outcome. (Source: Molecular Imaging and Biology)
Source: Molecular Imaging and Biology - June 30, 2022 Category: Molecular Biology Source Type: research
Highlighting the Undetectable — Fluorescence Molecular Imaging in Gastrointestinal Endoscopy
AbstractFlexible high-definition white-light endoscopy is the current gold standard in screening for cancer and its precursor lesions in the gastrointestinal tract. However, miss rates are high, especially in populations at high risk for developing gastrointestinal cancer (e.g., inflammatory bowel disease, Lynch syndrome, or Barrett ’s esophagus) where lesions tend to be flat and subtle. Fluorescence molecular endoscopy (FME) enables intraluminal visualization of (pre)malignant lesions based on specific biomolecular features rather than morphology by using fluorescently labeled molecular probes that bind to specific mole...
Source: Molecular Imaging and Biology - June 28, 2022 Category: Molecular Biology Source Type: research
PET/MR Imaging of a Lung Metastasis Model of Clear Cell Renal Cell Carcinoma with (2S,4R)-4-[18F]Fluoroglutamine
ConclusionsWe report one of the first direct orthotopic mouse models of ccRCC lung lesions. Using PET/MR imaging, lung tumors were easily discerned from normal tissue. Higher uptake of [18F]FGln was observed in a ccRCC cell line and lung lesions compared to HEK293 cells and normal lung tissue, respectively. [18F]FGln cell uptake was modulated by exogenous glutamine, V-9302, siRNA knockdown of ASCT2, and CB-839. Interestingly, in a pilot therapeutic study with CB-839, we observed no difference in treated tumors relative to untreated controls. This was in contrast with cellular studies, where CB-839 increased glutamine uptak...
Source: Molecular Imaging and Biology - June 22, 2022 Category: Molecular Biology Source Type: research
Quantifying the Impact of Signal-to-background Ratios on Surgical Discrimination of Fluorescent Lesions
ConclusionBy tracking the surgical instruments we were able to, for the first time, quantitatively and objectively assess how the instrument positioning is impacted by fluorescent SBR. Our findings suggest that in ideal situations a minimum SBR of 1.5 is required to discriminate fluorescent lesions, a substantially lower value than the SBR 2 often reported in literature. (Source: Molecular Imaging and Biology)
Source: Molecular Imaging and Biology - June 16, 2022 Category: Molecular Biology Source Type: research
Evaluation of [18F]F-TZ3108 for PET Imaging of Metabolic-Associated Fatty Liver Disease
ConclusionsThe expression of Sig-1R in the liver, measured by the PET tracer, [18F]F-TZ3108, was significantly decreased in mouse model of MAFLD. The [18F]F-TZ3108 PET/CT imaging may provide a novel means of visualization for ER stress in MAFLD or other diseases in vivo. (Source: Molecular Imaging and Biology)
Source: Molecular Imaging and Biology - June 15, 2022 Category: Molecular Biology Source Type: research
Striatal Dopaminergic Depletion Pattern Reflects Pathological Brain Perfusion Changes in Lewy Body Diseases
ConclusionsThis study suggests that regional changes in striatal123I-ioflupane accumulation on DAT-SPECT are related to brain perfusion changes in patients with LBD. (Source: Molecular Imaging and Biology)
Source: Molecular Imaging and Biology - June 14, 2022 Category: Molecular Biology Source Type: research
Pilot Study: PARP1 Imaging in Advanced Prostate Cancer
ConclusionsFTT-PET/CT may serve as an alternate biomarker for PARP1 expression and a potential method for PARPi treatment selection. (Source: Molecular Imaging and Biology)
Source: Molecular Imaging and Biology - June 14, 2022 Category: Molecular Biology Source Type: research
Non-invasive Imaging of Antisense Oligonucleotides in the Brain via In Vivo Click Chemistry
ConclusionA CNS-penetrant radioligand for pretargeted imaging was successfully demonstrated in a proof-of-concept study in rats, laying the groundwork for further optimization. (Source: Molecular Imaging and Biology)
Source: Molecular Imaging and Biology - June 2, 2022 Category: Molecular Biology Source Type: research
Evaluating the Accuracy of FUCCI Cell Cycle In Vivo Fluorescent Imaging to Assess Tumor Proliferation in Preclinical Oncology Models
ConclusionFluorescent imaging of the cell cycle provides a noninvasive accurate depiction of tumor progression and response to therapy, which may benefitin vivo testing of novel cancer therapeutics that target the cell cycle. (Source: Molecular Imaging and Biology)
Source: Molecular Imaging and Biology - June 1, 2022 Category: Molecular Biology Source Type: research
Early Diagnosis of Murine Sepsis-Associated Encephalopathy Using Dynamic PET/CT Imaging and Multiparametric MRI
ConclusionsThe dynamic PET (k4) was more sensitive than static PET (SUV) for early diagnosis of SAE and declinedKi was firstly found in murine SAE, which indicated the advantage of dynamic PET/CT in early detection and differential diagnosis of SAE. While MRI has a higher soft tissue resolution than PET/CT and can classify more subtle brain areas, the comprehensive utilization of the two modalities is helpful for managing SAE. (Source: Molecular Imaging and Biology)
Source: Molecular Imaging and Biology - May 25, 2022 Category: Molecular Biology Source Type: research
pHLIP Peptides Target Acidity in Activated Macrophages
ConclusionspHLIP peptides sense low cell surface pH, which triggers their insertion into the cell membrane. Unlike cancerous cells, activated macrophages do not retain inserted pHLIPs on their surfaces, instead their highly active membrane recycling moves the pHLIPs into endosomes. Targeting activated macrophages in diseased tissues may enable clinical visualization and therapeutic opportunities. (Source: Molecular Imaging and Biology)
Source: Molecular Imaging and Biology - May 23, 2022 Category: Molecular Biology Source Type: research
Detecting Validated Intracellular ROS Generation with 18F-dihydroethidine-Based PET
Conclusion[18F]DHE reports on ROS in a validated model of oxidative stress where perfusion (and tracer delivery) is unlikely to impact its pharmacokinetics. (Source: Molecular Imaging and Biology)
Source: Molecular Imaging and Biology - May 10, 2022 Category: Molecular Biology Source Type: research
