Detecting Validated Intracellular ROS Generation with 18F-dihydroethidine-Based PET
Conclusion[18F]DHE reports on ROS in a validated model of oxidative stress where perfusion (and tracer delivery) is unlikely to impact its pharmacokinetics. (Source: Molecular Imaging and Biology)
Source: Molecular Imaging and Biology - May 10, 2022 Category: Molecular Biology Source Type: research
Voxel-Based Analysis of the Relation of 3 ′-Deoxy-3′-[18F]fluorothymidine ([18F]FLT) PET and Diffusion-Weighted (DW) MR Signals in Subcutaneous Tumor Xenografts Does Not Reveal a Direct Spatial Relation of These Two Parameters
ConclusionsA spatial relation of water diffusion, as measured by DW-MRI, and cellular proliferation, as measured by [18F]FLT PET, cannot be detected in the experimental datasets investigated in this study. (Source: Molecular Imaging and Biology)
Source: Molecular Imaging and Biology - May 10, 2022 Category: Molecular Biology Source Type: research
Towards Optimized Bioavailability of 99mTc-Labeled Barbiturates for Non-invasive Imaging of Matrix Metalloproteinase Activity
ConclusionIntroduction of HYNIC/TPPTS into the barbiturate lead structure ([99mTc]MEA223) results in delayed renal elimination and allows non-invasive MMP imaging with high signal-to-noise ratios in a papillary thyroid tumor xenograft model. (Source: Molecular Imaging and Biology)
Source: Molecular Imaging and Biology - May 10, 2022 Category: Molecular Biology Source Type: research
Investigating the Feasibility of In Vivo Perfusion Imaging Methods for Spinal Cord Using Hyperpolarized [13C]t-Butanol and [13C,15N2]Urea
ConclusionThis study has demonstrated the feasibility of using hyperpolarized [13C]t-butanol and [13C,15N2]urea for assessingin vivo perfusion in cervical spinal cord. Due to differences in blood –brain barrier permeability, t-butanol rapidly crossed the blood–brain barrier and diffused into spine and brain tissue, while urea predominantly remained in vasculature. The results from this study suggest that this technique may provide unique non-invasive imaging tracers that are able to dire ctly monitor hemodynamic processes in the normal and injured spinal cord. (Source: Molecular Imaging and Biology)
Source: Molecular Imaging and Biology - May 10, 2022 Category: Molecular Biology Source Type: research
Repurposing [11C]MC1 for PET Imaging of Cyclooxygenase-2 in Colorectal Cancer Xenograft Mouse Models
Conclusions[11C]MC1 is a promising PET imaging agent for COX-2 in CRC and translation for cancer research should be considered. (Source: Molecular Imaging and Biology)
Source: Molecular Imaging and Biology - May 10, 2022 Category: Molecular Biology Source Type: research
Early Post-ischemic Brain Glucose Metabolism Is Dependent on Function of TLR2: a Study Using [18F]F-FDG PET-CT in a Mouse Model of Cardiac Arrest and Cardiopulmonary Resuscitation
ConclusionsThe altered mouse strains presented a different pattern in glucose uptake under normal and ischemic conditions, whereby the post-ischemic differences in glucose metabolism were associated with the function of key immune factor TLR2. There is evidence for using early FDG-PET-CT as an additional diagnostic tool after resuscitation. Further studies are needed to use PET-CT in predicting neurological outcomes. (Source: Molecular Imaging and Biology)
Source: Molecular Imaging and Biology - May 10, 2022 Category: Molecular Biology Source Type: research
First in Human Evaluation and Dosimetry Calculations for Peptide 124I-p5+14 —a Novel Radiotracer for the Detection of Systemic Amyloidosis Using PET/CT Imaging
ConclusionPeptide124I-p5+14 rapidly distributes to anatomic sites consistent with the presence of amyloid in patients with systemic AL. The dosimetry estimates established in this cohort are acceptable for whole-body PET/CT imaging. Pharmacokinetic parameters are heterogeneous and consistent with uptake of the tracer in an amyloid compartment. PET/CT imaging of124I-p5+14 may facilitate non-invasive detection of amyloid in multiple organ systems. (Source: Molecular Imaging and Biology)
Source: Molecular Imaging and Biology - May 10, 2022 Category: Molecular Biology Source Type: research
Value of Primary Rectal Tumor PET/MRI in the Prediction of Synchronic Metastatic Disease
ConclusionPET/MRI facilitated the identification of participants with a high risk of metastatic disease, though these findings were based mainly on MRI features. (Source: Molecular Imaging and Biology)
Source: Molecular Imaging and Biology - May 10, 2022 Category: Molecular Biology Source Type: research
Correction to: Value of Primary Rectal Tumor PET/MRI in the Prediction of Synchronic Metastatic Disease
(Source: Molecular Imaging and Biology)
Source: Molecular Imaging and Biology - May 10, 2022 Category: Molecular Biology Source Type: research
Comparison of [18F]fluciclovine and [18F]FDG PET/CT in Newly Diagnosed Multiple Myeloma Patients
ConclusionsBased on this pilot study, [18F]fluciclovine is a promising tracer for MM. The visual and semi-quantitative evaluations indicate that [18F]fluciclovine PET/CT can out-perform [18F]FDG PET/CT at diagnosis. (Source: Molecular Imaging and Biology)
Source: Molecular Imaging and Biology - May 2, 2022 Category: Molecular Biology Source Type: research
Comparisons of Quantitative Parameters of Ga-68-Labelled Fibroblast Activating Protein Inhibitor (FAPI) PET/CT and [18F]F-FDG PET/CT in Patients with Liver Malignancies
Conclusion[68 Ga]Ga-FAPI PET/CT with dedicated liver PET/MRI shows potential for superior detection of hepatic malignancy compared with [18F]FDG PET/CT or MRI alone. (Source: Molecular Imaging and Biology)
Source: Molecular Imaging and Biology - April 29, 2022 Category: Molecular Biology Source Type: research
Fabrication of Customizable Intraplaque Hemorrhage Phantoms for Magnetic Resonance Imaging
ConclusionsThe cylindrical IPH phantom accurately modeled the short T1 time characteristic of methemoglobin-laden IPH, with the IPH sites exhibiting little variation in imaging properties over 31 days. Furthermore, MPRAGE images of the anatomical atherosclerosis replicas closely matched those of clinical plaques. In combination, these phantoms will allow for IPH imaging protocol standardization and thus facilitate future multicenter IPH imaging. (Source: Molecular Imaging and Biology)
Source: Molecular Imaging and Biology - April 29, 2022 Category: Molecular Biology Source Type: research
FDG PET/CT and Dosimetric Studies of 177Lu-Lilotomab Satetraxetan in a First-in-Human Trial for Relapsed Indolent non-Hodgkin Lymphoma —Are We Hitting the Target?
ConclusiontTAD of ≥ 200 cGy may prove valuable to ensure clinical response, but further studies are needed to confirm this in a larger patient population. Furthermore, this work indicates that higher baseline tumor burden (up to 585 cm3) did not induce reduction in radioimmunoconjugate accumulation in tumor. (Source: Molecular Imaging and Biology)
Source: Molecular Imaging and Biology - April 29, 2022 Category: Molecular Biology Source Type: research
[18F]BTK-1: A Novel Positron Emission Tomography Tracer for Imaging Bruton ’s Tyrosine Kinase
Conclusion[18F]BTK-1 is a promising PET tracer for imaging of BTK, which could provide valuable information for patient selection, drug dose determination, and improving our understanding of BTK biology in humans. (Source: Molecular Imaging and Biology)
Source: Molecular Imaging and Biology - April 28, 2022 Category: Molecular Biology Source Type: research
Hyperpolarized [1-13C]Pyruvate Magnetic Resonance Spectroscopic Imaging for Evaluation of Early Response to Tyrosine Kinase Inhibition Therapy in Gastric Cancer
ConclusionsHP-13C MRSI is a more representative biomarker of early metabolic changes in response to pan-TKI in GCa than [18F]FDG PET and could be used for early prediction of response to targeted therapies. (Source: Molecular Imaging and Biology)
Source: Molecular Imaging and Biology - April 25, 2022 Category: Molecular Biology Source Type: research
