Development of Duramycin-Based Molecular Probes for Cell Death Imaging
AbstractCell death is involved in numerous pathological conditions such as cardiovascular disorders, ischemic stroke and organ transplant rejection, and plays a critical role in the treatment of cancer. Cell death imaging can serve as a noninvasive means to detect the severity of tissue damage, monitor the progression of diseases, and evaluate the effectiveness of treatments, which help to provide prognostic information and guide the formulation of individualized treatment plans. The high abundance of phosphatidylethanolamine (PE), which is predominantly confined to the inner leaflet of the lipid bilayer membrane in health...
Source: Molecular Imaging and Biology - February 10, 2022 Category: Molecular Biology Source Type: research
Developing a Microbubble-Based Contrast Agent for Synchrotron Multiple-Image Radiography
ConclusionsThese data indicate that lipid microbubbles 6 –10 µm are candidates as contrast agents for MIR, specifically for USAXS. A minimum concentration of 5 × 107 microbubbles (lipid-shell 6 –10 µm) per milliliter was needed to generate a detectable signal. (Source: Molecular Imaging and Biology)
Source: Molecular Imaging and Biology - February 8, 2022 Category: Molecular Biology Source Type: research
Application of Noninvasive Imaging to Combined Immune Checkpoint Inhibitors for Breast Cancer: Facts and Future
AbstractWith the application of mono-immunotherapy in cancer, particularly immune checkpoint inhibitors, improved outcomes have been achieved. However, there are several limitations to immunotherapy, such as a poor response to the drugs, immune resistance, and immune-related adverse events. In recent years, studies of preclinical animal models and clinical trials have demonstrated that immune checkpoint inhibitors for breast cancer can significantly prolong the overall survival and quality of patients ’ lives. Meanwhile, combined immune checkpoint inhibitor treatment has attracted researchers’ attention and showed grea...
Source: Molecular Imaging and Biology - January 31, 2022 Category: Molecular Biology Source Type: research
Fluorine MR Imaging Probes Dynamic Migratory Profiles of Perfluorocarbon-Loaded Dendritic Cells After Streptozotocin-Induced Inflammation
ConclusionWe showed the potential of19F MRI for the non-invasive visualization and quantification of migrating immune cells in models for pancreatic inflammation after STZ administration. Without any intrinsic background signal,19F MRI serves as a highly specific imaging tool to study the migration of diabetic-prone BMDCs in T1D models in vivo. This approach could particularly be of interest for the longitudinal assessment of established or novel anti-inflammatory therapeutic approaches in preclinical models. (Source: Molecular Imaging and Biology)
Source: Molecular Imaging and Biology - January 20, 2022 Category: Molecular Biology Source Type: research
Imaging Pulmonary Blood Vessels and Ventilation-Perfusion Mismatch in COVID-19
AbstractCOVID-19 hypoxemic patients although sharing a same etiology (SARS-CoV-2 infection) present themselves quite differently from one another. Patients also respond differently to prescribed medicine and to prone Vs supine bed positions. A severe pulmonary ventilation-perfusion mismatch usually triggers moderate to severe COVID-19 cases. Imaging can aid the physician in assessing severity of COVID-19. Although useful for their portability X-ray and ultrasound serving on the frontline to evaluate lung parenchymal abnormalities are unable to provide information about pulmonary vasculature and blood flow redistribution wh...
Source: Molecular Imaging and Biology - January 18, 2022 Category: Molecular Biology Source Type: research
Publisher Correction to: PET/MRI and PET/CT Radiomics in Primary Cervical Cancer: A Pilot Study on the Correlation of Pelvic PET, MRI, and CT Derived Image Features
(Source: Molecular Imaging and Biology)
Source: Molecular Imaging and Biology - January 16, 2022 Category: Molecular Biology Source Type: research
Role of Radiomics-Based Baseline PET/CT Imaging in Lymphoma: Diagnosis, Prognosis, and Response Assessment
AbstractRadiomic analysis provides information on the underlying tumour heterogeneity in lymphoma, reflecting the real-time evolution of malignancy. 2-Deoxy-2-[18F] fluoro-D-glucose positron emission tomography ([18F] FDG PET/CT) imaging is recommended before, during, and at the end of treatment for almost all lymphoma patients. This methodology offers high specificity and sensitivity, which can aid in accurate staging and assist in prompt treatment. Pretreatment [18F] FDG PET/CT-based radiomics facilitates improved diagnostic ability, guides individual treatment regimens, and boosts outcome prognosis based on heterogeneit...
Source: Molecular Imaging and Biology - January 14, 2022 Category: Molecular Biology Source Type: research
RAS-Driven Macropinocytosis of Albumin or Dextran Reveals Mutation-Specific Target Engagement of RAS p.G12C Inhibitor ARS-1620 by NIR-Fluorescence Imaging
ConclusionsThese data provide a novel approach using NIR-labeled human serum albumin to identify and monitor RAS-driven tumors as well as evaluate the on-target efficacyin vivo of inhibitors, such as ARS-1620. (Source: Molecular Imaging and Biology)
Source: Molecular Imaging and Biology - December 14, 2021 Category: Molecular Biology Source Type: research
Correction to: Whole ‑Body Imaging to Assess Cell‑Based Immunotherapy: Preclinical Studies with an Update on Clinical Translation
(Source: Molecular Imaging and Biology)
Source: Molecular Imaging and Biology - December 14, 2021 Category: Molecular Biology Source Type: research
Intratumoral and Peritumoral Analysis of Mammography, Tomosynthesis, and Multiparametric MRI for Predicting Ki-67 Level in Breast Cancer: a Radiomics-Based Study
ConclusionsPeritumoral regions can provide complementary information to intratumoral regions in mammography and MRI for the prediction of Ki-67 levels. The MRI performed better than mammography in terms of AUC and specificity but weaker in sensitivity. The nomogram has a predictive advantage over each modality and could be a potential tool for predicting Ki-67 levels in breast cancer. (Source: Molecular Imaging and Biology)
Source: Molecular Imaging and Biology - December 13, 2021 Category: Molecular Biology Source Type: research
Comparison of Five Near-Infrared Fluorescent Folate Conjugates in an Ovarian Cancer Model
ConclusionsThe choice of fluorophore has a significant impact on the biodistribution and tumour contrast. ZW800-1 Forte (2) exhibited the best properties of those tested, with significant specific fluorescence signal. (Source: Molecular Imaging and Biology)
Source: Molecular Imaging and Biology - December 10, 2021 Category: Molecular Biology Source Type: research
Monitoring Immune Cell Function Through Optical Imaging: a Review Highlighting Transgenic Mouse Models
AbstractTransgenic mouse models have facilitated research of human diseases and validation of therapeutic approaches. Inclusion of optical reporter genes (fluorescent or bioluminescent genes) in the targeting vectors used to develop such models makesin vivo imaging of cellular and molecular events possible, from the microscale to the macroscale. In particular, transgenic mouse models expressing optical reporter genes allowed accurately distinguishing immune cell types from traffickingin vivo using intravital microscopy or whole-body optical imaging. Besides lineage tracing and trafficking of different subsets of immune cel...
Source: Molecular Imaging and Biology - November 4, 2021 Category: Molecular Biology Source Type: research
Correction to: Longitudinal FRET Imaging of Glucose and Lactate Dynamics and Response to Therapy in Breast Cancer Cells
(Source: Molecular Imaging and Biology)
Source: Molecular Imaging and Biology - November 2, 2021 Category: Molecular Biology Source Type: research
A Pilot Study of Dynamic 18F-DCFPyL PET/CT Imaging of Prostate Adenocarcinoma in High-Risk Primary Prostate Cancer Patients
ConclusionHigh-risk primary prostate cancer is readily identified on dynamic and static, delayed,18F-DCFPyL PET images. The tumor-to-background ratio increases over time, with optimal18F-DCFPyL PET/CT imaging at 120 min p.i. for evaluation of prostate cancer, but not necessarily ideal for clinical application. Primary prostate cancer demonstrates different uptake kinetics in comparison to BPH and normal prostate tissue. The 15-fold difference inKi between prostate cancer and non-cancer (BPH and normal) tissues translates to an ability to distinguish prostate cancer from normal tissue at time points as early as 5 to 10 min ...
Source: Molecular Imaging and Biology - November 1, 2021 Category: Molecular Biology Source Type: research
Prognostic Value of Fluorine-19 MRI Oximetry Monitoring in cancer
AbstractHypoxia is a key prognostic indicator in most solid tumors, as it is correlated to tumor angiogenesis, metastasis, recurrence, and response to therapy. Accurate measurement and mapping of tumor oxygenation profile and changes upon intervention could facilitate disease progression assessment and assist in treatment planning. Currently, no gold standard exists for non-invasive spatiotemporal measurement of hypoxia. Magnetic resonance imaging (MRI) represents an attractive option as it is a clinically available and non-ionizing imaging modality. Specifically, perfluorocarbon (PFC) beacons can be externally introduced ...
Source: Molecular Imaging and Biology - October 27, 2021 Category: Molecular Biology Source Type: research
