Radiosynthesis and Analysis of (S)-4-(3-[18F]Fluoropropyl)-L-Glutamic Acid
ConclusionStability tests using a 4.6 GBq dose with a radioactivity volumetric concentration of 369 MBq mL−1 at the end of synthesis showed no observable radiolysis 3 h after production. The formulated product is of high radiochemical purity (> 95%) and higher molar activity compared to previous methods and is safe to inject into mice up to 3 h after production. (Source: Molecular Imaging and Biology)
Source: Molecular Imaging and Biology - December 16, 2022 Category: Molecular Biology Source Type: research
Recent Trends in Diagnostic Biomarkers of Tumor Microenvironment
Abstract
The tumor microenvironment (TME) play critical roles in tumor survival, progression, and metastasis and can be considered potential targets for molecular imaging of cancer. The targeting agents for imaging of TME components (e.g., fibroblasts, mesenchymal stromal cells, immune cells, extracellular matrix, blood vessels) provide a promising strategy to target these biomarkers for the early diagnosis of cancers. Moreover, various cancer types have similar tumor immune microenvironment (TIME) features that targeting those biomarkers and offer clinically translatable molecular imaging of cancers. In this review, we...
Source: Molecular Imaging and Biology - December 14, 2022 Category: Molecular Biology Source Type: research
Community Survey Results Show that Standardisation of Preclinical Imaging Techniques Remains a Challenge
ConclusionsStandardisation of preclinical imaging techniques remains a challenge and hinders the transformative potential of preclinical imaging to augment biomedical research pipelines by serving as an easy vehicle for translation of research findings to the clinic. Data collected in this project show that there is a need to promote and disseminate already available tools to standardise preclinical imaging practices. (Source: Molecular Imaging and Biology)
Source: Molecular Imaging and Biology - December 8, 2022 Category: Molecular Biology Source Type: research
A Practical Quality Assurance Procedure for Data Acquisitions in Preclinical Simultaneous PET/MR Systems
AbstractThe availability of preclinical simultaneous PET/MR imaging systems has been increasing in recent years. Therefore, this technique is progressively moving from the hands of pure physicists towards those of scientists more involved in pharmacology and biology. Unfortunately, these combined scanners can be prone to artefacts and deviation of their characteristics under the influence of external factors or mutual interference between subsystems. This may compromise the image quality as well as the quantitative aspects of PET and MR data. Hence, quality assurance is crucial to avoid loss of animals and experiments. A p...
Source: Molecular Imaging and Biology - December 7, 2022 Category: Molecular Biology Source Type: research
Contrast Media Research Symposium 2022
(Source: Molecular Imaging and Biology)
Source: Molecular Imaging and Biology - November 29, 2022 Category: Molecular Biology Source Type: research
Current and Future Applications of Fluorescence Guidance in Orthopaedic Surgery
AbstractFluorescence-guided surgery (FGS) is an evolving field that seeks to identify important anatomic structures or physiologic phenomena with helpful relevance to the execution of surgical procedures. Fluorescence labeling occurs generally via the administration of fluorescent reporters that may be molecularly targeted, enzyme-activated, or untargeted, vascular probes. Fluorescence guidance has substantially changed care strategies in numerous surgical fields; however, investigation and adoption in orthopaedic surgery have lagged. FGS shows the potential for improving patient care in orthopaedics via several applicatio...
Source: Molecular Imaging and Biology - November 29, 2022 Category: Molecular Biology Source Type: research
Magnetic Particle Imaging Is a Sensitive In Vivo Imaging Modality for the Detection of Dendritic Cell Migration
ConclusionsHere, we describe the first study to use MPI to detect and track DC in a migration model with immunotherapeutic applications. We also bring attention to the issue of resolving unequal signals within close proximity, a challenge for any pre-clinical study using a highly concentrated tracer bolus that shadows nearby lower signals. (Source: Molecular Imaging and Biology)
Source: Molecular Imaging and Biology - November 23, 2022 Category: Molecular Biology Source Type: research
Management Impact of Metachronous Oligometastatic Disease Identified on 18F-Fluciclovine (Axumin ™) PET/CT in Biochemically Recurrent Prostate Cancer
ConclusionThe incidence rate of oligometastatic disease in men with first BCR of PCA undergoing18F-fluciclovine PET/CT for imaging evaluation of BCR was 23.6% in our eligible patient population. There was no significant association between serum PSA level and the number of oligometastases. Treatment management was affected in 57.1% of patients with oligometastases. (Source: Molecular Imaging and Biology)
Source: Molecular Imaging and Biology - November 23, 2022 Category: Molecular Biology Source Type: research
Glucose Infusion Induced Change in Intracellular pH and Its Relationship with Tumor Glycolysis in a C6 Rat Model of Glioblastoma
ConclusionAACID detected the changes in pHi induced by glucose infusion. Significant correlations between tumor glycolytic measurement of Lac:Pyr and tumoral and peritumoral pHi and ∆pHi suggest the intrinsic relationship between tumor glycolytic metabolism and the tumor pH environment as well as the peritumor pH environment. (Source: Molecular Imaging and Biology)
Source: Molecular Imaging and Biology - November 23, 2022 Category: Molecular Biology Source Type: research
Correction to: Synthesis and Preliminary Evaluation of an 18F-Labeled Oleate Analog to Image Fatty Acid Beta-Oxidation in the Absence of Metabolic Defluorination
(Source: Molecular Imaging and Biology)
Source: Molecular Imaging and Biology - November 15, 2022 Category: Molecular Biology Source Type: research
PSMA-1007 Uptake in Ganglia of the Sympathetic Trunk and Its Intra-individual Reproducibility
ConclusionsThe first systematically described physiological [18F]PSMA-1007 uptake in ganglia of the sympathetic trunk showed a low variability of SUVmax or SUVmean and a good intra-individual reproducibility of [18F]PSMA-1007 uptake in follow-up scans. These findings might improve and guide the differentiation of ganglia from possible malignant lesions. (Source: Molecular Imaging and Biology)
Source: Molecular Imaging and Biology - November 11, 2022 Category: Molecular Biology Source Type: research
Rapid and Quantitative Intraoperative Pathology-Assisted Surgery by Paired-Agent Imaging-Derived Confidence Map
ConclusionThis study demonstrated that PAI improved tumor detection in frozen sections with high diagnostic accuracy and rapid analysis times. The novel PAI confidence map improved the contrast in vascular tumors and differentiability in avascular tumors. With a larger database, the PAI confidence map promises to standardize fluorescence imaging in intraoperative pathology-assisted surgery (IPAS). (Source: Molecular Imaging and Biology)
Source: Molecular Imaging and Biology - October 31, 2022 Category: Molecular Biology Source Type: research
3D-Printed Tumor Phantoms for Assessment of In Vivo Fluorescence Imaging Analysis Methods
Conclusions3D printing techniques provide a platform for demonstrating complex biological models that introduce real-world complexities for quantifying fluorescence image data. Controlled iterative development of these phantom designs can be used as a tool to advance the field and provide context for consensus-building beyond performance assessment of fluorescence imaging platforms, and extend support for standardizing how quantitative metrics are extracted from imaging data and reported in literature. (Source: Molecular Imaging and Biology)
Source: Molecular Imaging and Biology - October 28, 2022 Category: Molecular Biology Source Type: research
Early Reduction of Glucose Consumption Is a Biomarker of Kinase Inhibitor Efficacy Which Can Be Reversed with GLUT1 Overexpression in Lung Cancer Cells
ConclusionsOur results demonstrate that the early inhibition of lung cancer glucose consumption in response to a kinase inhibitor is a strong biomarker of and is often required for the subsequent inhibition of cell growth. Early inhibition of glucose consumption may provide complementary information to other biomarkers in determining whether a drug will effectively limit tumor growth. (Source: Molecular Imaging and Biology)
Source: Molecular Imaging and Biology - October 25, 2022 Category: Molecular Biology Source Type: research
Immuno-PET Monitoring of CD8+ T Cell Infiltration Post ICOS Agonist Antibody Treatment Alone and in Combination with PD-1 Blocking Antibody Using a 89Zr Anti-CD8+ Mouse Minibody in EMT6 Syngeneic Tumor Mouse
ConclusionTo our knowledge, this is the first detailed description of the use of a novel immune-PET imaging technique to assess the kinetics of CD8+ T-cell infiltration into tumor and lymphoid tissues following ICOS agonist and PD-1 blocking antibody therapy. By demonstrating the capacity for increased spatial and temporal resolution of CD8+ T-cell infiltration across tumors and lymphoid tissues, these observations underscore the widespread potential clinical utility of non-invasive PET imaging for T-cell-based immunotherapy in cancer. (Source: Molecular Imaging and Biology)
Source: Molecular Imaging and Biology - October 20, 2022 Category: Molecular Biology Source Type: research
