PET/MRI and PET/CT Radiomics in Primary Cervical Cancer: A Pilot Study on the Correlation of Pelvic PET, MRI, and CT Derived Image Features
ConclusionsWe demonstrated strong correlation of many extracted radiomic features between PET/MRI and PET/CT. Eight radiomic features calculated on PET/CT and PET/MRI were significantly different between local and metastatic CCa. This study paves the way for future studies to evaluate the diagnostic and predictive potential of radiomics that could guide clinicians toward personalized patients care. (Source: Molecular Imaging and Biology)
Source: Molecular Imaging and Biology - October 7, 2021 Category: Molecular Biology Source Type: research
Amyloid- β PET Classification on Cognitive Aging Stages Using the Centiloid Scale
ConclusionSuperAgers exhibited a similar A β load to AC and MC, differing in cognitive performance. Independently of cut-point used (10 CL, 19 CL, or 30 CL), three SA individuals were classified as Aβ positive, showing the duality between the individual’s clinics and the biological definition of Alzheimer’s. Different cut-points lead t o Aβ positivity classification mismatch in individuals, and an extra care is needed for individuals who have a CL value between 10 and 30 CL. (Source: Molecular Imaging and Biology)
Source: Molecular Imaging and Biology - October 5, 2021 Category: Molecular Biology Source Type: research
Longitudinal FRET Imaging of Glucose and Lactate Dynamics and Response to Therapy in Breast Cancer Cells
ConclusionsFRET reporters can track intracellular glucose and lactate dynamics in cancer cells, providing insight into tumor metabolism and response to therapy over time. (Source: Molecular Imaging and Biology)
Source: Molecular Imaging and Biology - October 5, 2021 Category: Molecular Biology Source Type: research
Correction to: Paramagnetic Fluorinated Nanoemulsions for In Vivo F-19 MRI
(Source: Molecular Imaging and Biology)
Source: Molecular Imaging and Biology - September 30, 2021 Category: Molecular Biology Source Type: research
In Vivo MRI Tracking of Tumor Vaccination and Antigen Presentation by Dendritic Cells
AbstractCancer vaccination using tumor antigen-primed dendritic cells (DCs) was introduced in the clinic some 25 years ago, but the overall outcome has not lived up to initial expectations. There are to the complexity of the immune response, there are many factors that determine the efficacy of DC therapy. These include accurate administration of DCs in the target tissue site without unwanted cell dispersion /backflow, sufficient numbers of tumor antigen-primed DCs homing to lymph nodes (LNs), and proper timing of immunoadjuvant administration. To address these uncertainties, proton (1H) and fluorine (19F) magnetic reson...
Source: Molecular Imaging and Biology - September 28, 2021 Category: Molecular Biology Source Type: research
Potential of Gold Nanoparticles for Noninvasive Imaging and Therapy for Vascular Inflammation
ConclusionsMacrophages with GNPs had reduced viability upon NIR laser exposure. GNPs intravenously injected into mice accumulated in sites of vascular inflammation, allowing detection of carotid atherosclerosis and AAAs in CT imaging. Thus, GNPs have potential as multifunctional biologically compatible particles for the detection and therapy of vascular inflammation. (Source: Molecular Imaging and Biology)
Source: Molecular Imaging and Biology - September 27, 2021 Category: Molecular Biology Source Type: research
ImmunoPET: harnessing antibodies for imaging immune cells
AbstractDramatic, but uneven, progress in the development of immunotherapies for cancer has created a need for better diagnostic technologies including innovative non-invasive imaging approaches. This review discusses challenges and opportunities for molecular imaging in immuno-oncology and focuses on the unique role that antibodies can fill. ImmunoPET has been implemented for detection of immune cell subsets, activation and inhibitory biomarkers, tracking adoptively transferred cellular therapeutics, and many additional applications in preclinical models. Parallel progress in radionuclide availability and infrastructure s...
Source: Molecular Imaging and Biology - September 22, 2021 Category: Molecular Biology Source Type: research
Development and Validation of a PET/SPECT Radiopharmaceutical in Oncology
AbstractIn oncology, biomarker research aimed to provide insights on cancer biology via positron emission tomography (PET) and single photon emission tomography (SPECT) imaging has seen an incredible growth in the past two decades. Despite the increased number of publications on PET/SPECT radiopharmaceuticals, the field lacked standardization of in vitro and in vivo parameters necessary for the characterization of any radiotracer. Through the efforts of the World Molecular Imaging Society Education Committee, this white paper lays down validation studies that are essential to chemically and biologically characterize new ra...
Source: Molecular Imaging and Biology - September 20, 2021 Category: Molecular Biology Source Type: research
Direct Comparison of [18F]F-DPA with [18F]DPA-714 and [11C]PBR28 for Neuroinflammation Imaging in the same Alzheimer ’s Disease Model Mice and Healthy Controls
Conclusions[18F]F-DPA displays higher brain uptake, higher TG-to-WT SUVRCB ratios, and faster clearance than [18F]DPA-714 and [11C]PBR28, and could prove useful for detecting low levels of inflammation and allow for shorter dynamic PET scans. (Source: Molecular Imaging and Biology)
Source: Molecular Imaging and Biology - September 20, 2021 Category: Molecular Biology Source Type: research
Incremental Impact of [68 Ga]Ga-PSMA-11 PET/CT in Primary N and M Staging of Prostate Cancer Prior to Curative-Intent Surgery: a Prospective Clinical Trial in Comparison with mpMRI
Conclusion[68 Ga]Ga-PSMA-11 PET/CT shows high diagnostic performance for N and M staging of patients with intermediate- and high-risk prostate cancer and seems to be superior to pelvic mpMRI in the detection of locoregional lymph node metastases. A significant correlation was found between SUVmax of the intrapr ostatic index lesion and risk stratification based on tPSA level and GS. The results of this study emphasize again on the role of metabolic molecular imaging using specific tracers in selected patients, leading to tailored therapy approach. (Source: Molecular Imaging and Biology)
Source: Molecular Imaging and Biology - September 14, 2021 Category: Molecular Biology Source Type: research
Positivity Rate of [18F]Fluciclovine PET/CT in Patients with Suspected Prostate Cancer Recurrence at PSA Levels Below 1 ng/mL
ConclusionsDespite low PSA values, more than half of patients had positive [18F]fluciclovine PET/CT findings. Patients with low PSA levels may demonstrate suspicious findings outside of the pelvis, including abdominal lymph nodes and metastatic disease to bones and lungs. (Source: Molecular Imaging and Biology)
Source: Molecular Imaging and Biology - September 3, 2021 Category: Molecular Biology Source Type: research
Synthesis and Biological Evaluation of [18F]FECNT-d4 as a Novel PET Agent for Dopamine Transporter Imaging
ConclusionThe deuterated compound [18F]FECNT-d4 may serve as a promising PET imaging agent to assess DAT-related disorders. (Source: Molecular Imaging and Biology)
Source: Molecular Imaging and Biology - September 2, 2021 Category: Molecular Biology Source Type: research
Monitoring PSMA Responses to ADT in Prostate Cancer Patient-Derived Xenograft Mouse Models Using [18F]DCFPyL PET Imaging
ConclusionTumor responses to ADT varied from sensitive to resistant among these LuCaP PDXs, while only the high PSMA expressing LuCaP model exhibited an increase in PSMA levels in response to ADT. These models may be useful in understanding the clinical relevance of PSMA PET responses to ADT and potentially the relationship to disease progression as it may relate to the genomic signature. (Source: Molecular Imaging and Biology)
Source: Molecular Imaging and Biology - September 2, 2021 Category: Molecular Biology Source Type: research
Comparison of the [18F]-FDG and [18F]-FLT PET Tracers in the Evaluation of the Preclinical Proton Therapy Response in Hepatocellular Carcinoma
ConclusionWe showed that the use of the [18F]-FDG and [18F]-FLT radiolabeled molecules can provide useful and complementary information for longitudinal follow-up of small animal proton therapy studies in the context of HCC. [18F]-FDG PET imaging enables a treatment monitoring several days/weeks postirradiation. On the other hand, [18F]-FLT could represent a good candidate to monitor the treatment few days postirradiation, in the context of hypo-fractioned and close irradiation planning. This opens new perspectives in terms of treatment efficacy verification depending on the irradiation scheme. (Source: Molecular Imaging and Biology)
Source: Molecular Imaging and Biology - September 2, 2021 Category: Molecular Biology Source Type: research
Desorption Electrospray Ionization Mass Spectrometry Imaging of Cimbi-36, a 5-HT2A Receptor Agonist, with Direct Comparison to Autoradiography and Positron Emission Tomography
ConclusionsDESI imaging from anin vivo dosing experiment showed distribution of the PET tracer remarkably similar to what was obtained by autoradiography of anin vitro incubation experiment, indicating that the obtained results represent actual binding to certain receptors in the brain. DESI-MSI is suggested as a cost-effective screening tool, which does not rely on labelling of compounds. (Source: Molecular Imaging and Biology)
Source: Molecular Imaging and Biology - September 2, 2021 Category: Molecular Biology Source Type: research
