Effects of Escitalopram on the Functional Neural Circuits in an Animal Model of Adolescent Depression
ConclusionThe administration of escitalopram had no therapeutic effect on the adolescent depression. (Source: Molecular Imaging and Biology)
Source: Molecular Imaging and Biology - July 11, 2023 Category: Molecular Biology Source Type: research
2-deoxy-2-[18F]fluoro-D-glucose Positron Emission Tomography to Monitor Lung Inflammation and Therapeutic Response to Dexamethasone in a Murine Model of Acute Lung Injury
Conclusions[18F]FDG PET noninvasively detects lung inflammation in ALI and its response to anti-inflammatory therapy in a preclinical model. However, high [18F]FDG uptake by bone, brown fat, and myocardium remains a technical limitation for quantification of [18F]FDG in the lungs. (Source: Molecular Imaging and Biology)
Source: Molecular Imaging and Biology - July 11, 2023 Category: Molecular Biology Source Type: research
In vivo imaging of acute physiological responses after treatment of cancer with near-infrared photoimmunotherapy
ConclusionsWe successfully monitored inflammatory edema and changes in oxygen levels during NIR-PIT. Our findings on the acute physiological responses after light irradiation will help to develop effective measures to minimize the side effects in NIR-PIT. (Source: Molecular Imaging and Biology)
Source: Molecular Imaging and Biology - July 11, 2023 Category: Molecular Biology Source Type: research
Photoacoustic Microscopic Imaging of Cerebral Vessels for Intensive Monitoring of Metabolic Acidosis
ConclusionsOur photoacoustic imaging approach has great potential for rapid detection of metabolic acidosis and brain oxygen metabolism, which could potentially be applied as a bedside monitoring method for brain protection and timely treatment of acid –base abnormalities. (Source: Molecular Imaging and Biology)
Source: Molecular Imaging and Biology - July 11, 2023 Category: Molecular Biology Source Type: research
Improved Quantitative Analysis Method for Magnetic Particle Imaging Based on Deblurring and Region Scalable Fitting
ConclusionsOur proposed DeRSF method was successfully used for improved MPI quantitative analysis. More importantly, this method also showed accurate quantitative results on images with different shapes and tracer concentrations in both phantom and in vivo data, which laid the foundation for the biomedical study of MPI. (Source: Molecular Imaging and Biology)
Source: Molecular Imaging and Biology - July 11, 2023 Category: Molecular Biology Source Type: research
Identification of a Putative α-synuclein Radioligand Using an in silico Similarity Search
ConclusionThrough a relatively simple ligand-based similarity search, we identified a new radioligand that binds with high affinity (<10 nM) to α-synuclein fibrils and PD tissue. Although the radioligand has suboptimal selectivity for α-synuclein towards Aβ and high non-specific binding, we show here that a simplein silico approach is a promising strategy to identify novel ligands for target proteins in the CNS with the potential to be radiolabeled for PET neuroimaging studies. (Source: Molecular Imaging and Biology)
Source: Molecular Imaging and Biology - July 11, 2023 Category: Molecular Biology Source Type: research
Bone Turnover in Patients with Chronic Kidney Disease Stage 5D and Healthy Controls — a Quantitative [18F]Fluoride PET Study
ConclusionsDynamic 30 min [18F]fluoride PET/CT with a population based input curve scaled to a single venous plasma sample is a feasible and precise non-invasive diagnostic method for the assessment of bone turnover in patients with CKD. The method may potentially allow for earlier and more precise diagnosis and may be useful for assessment of treatment effects, which is crucial for development of future treatment strategies. (Source: Molecular Imaging and Biology)
Source: Molecular Imaging and Biology - July 11, 2023 Category: Molecular Biology Source Type: research
Detection of Endometriosis Lesions Using Gd-Based Collagen I Targeting Probe in Murine Models of Endometriosis
ConclusionsThis study provides evidence for feasibility of targeting collagen type I in the endometriotic lesions using EP3533 probe. Our future work includes investigation of the utility of this probe for therapeutic delivery in endometriosis to inhibit signaling pathways that cause the disease. (Source: Molecular Imaging and Biology)
Source: Molecular Imaging and Biology - July 7, 2023 Category: Molecular Biology Source Type: research
68Ga-FAPI-04 PET for Surveillance of Anastomotic Recurrence in Postoperative Patients with Gastrointestinal Cancer: a Comparative Study with 18F-FDG PET
ConclusionsBoth tracers displayed high NPVs in identifying anastomotic recurrence with a higher sensitivity to68Ga-FAPI-04. Tracer uptake at anastomotic sites does not decrease significantly over time, which results in low PPVs for both PET. Therefore, it is difficult to differentiate anastomotic recurrence from inflammation on either PET imaging.Graphical abstract (Source: Molecular Imaging and Biology)
Source: Molecular Imaging and Biology - July 5, 2023 Category: Molecular Biology Source Type: research
A Machine Learning Approach Using [18F]FDG PET-Based Radiomics for Prediction of Tumor Grade and Prognosis in Pancreatic Neuroendocrine Tumor
ConclusionsIntegration of clinical features and [18F]FDG PET-based radiomics using ML algorithms improved the prediction of high-grade PNET and poor prognosis in a non-invasive manner. (Source: Molecular Imaging and Biology)
Source: Molecular Imaging and Biology - July 3, 2023 Category: Molecular Biology Source Type: research
Towards Characterization of Skin Melanoma in the Clinic by Electron Paramagnetic Resonance (EPR) Spectroscopy and Imaging of Melanin
We describe key elements that allow EPR to move fromin vitro studies toin vivo and finally to patients for melanoma studies. Finally, we provide a critical view on challenges to meet to make EPR operational in the clinic to characterize pigmented lesions. (Source: Molecular Imaging and Biology)
Source: Molecular Imaging and Biology - June 30, 2023 Category: Molecular Biology Source Type: research
Inter-user Comparison for Quantification of Superparamagnetic Iron Oxides with Magnetic Particle Imaging Across Two Institutions Highlights a Need for Standardized Approaches
ConclusionsThis study highlights that there are many factors that contribute to the accuracy and reproducibility of MPI quantification, including variation between MPI imagers and users, despite pre-defined experimental setup, image acquisition parameters, and ROI selection analysis. (Source: Molecular Imaging and Biology)
Source: Molecular Imaging and Biology - June 29, 2023 Category: Molecular Biology Source Type: research
Evaluating Receptor-Specific Fresh Specimen Staining for Tumor Margin Detection in Clinical Breast Specimens
ConclusionsThe results from this preliminary study of rapid receptor-specific staining in human specimens were consistent with prior preclinical results and demonstrated promising diagnostic potential. (Source: Molecular Imaging and Biology)
Source: Molecular Imaging and Biology - June 23, 2023 Category: Molecular Biology Source Type: research
Multimodality PET and Near-Infrared Fluorescence Intraoperative Imaging of CEA-Positive Colorectal Cancer
ConclusionsThis study demonstrates the potential of a pegylated anti-CEA M5A-IR800-Sidewinder for NIR fluorescence/PET/MR multimodality imaging for intraoperative fluorescence guided surgery. (Source: Molecular Imaging and Biology)
Source: Molecular Imaging and Biology - June 21, 2023 Category: Molecular Biology Source Type: research
Lymphoma-Sink Effect in Marginal Zone Lymphoma Based on CXCR4-Targeted Molecular Imaging
ConclusionsInvestigating a lymphoma-sink effect in patients with hematological neoplasms, we observed no relevant associations between lymphoma burden and uptake in normal organs. Those observations may have therapeutic implications, e.g., for “cold” SDF1-pathway disrupting or “hot,” CXCR4-directed radiolabeled drugs, as with higher lymphoma load, normal organ uptake seems to remain stable. (Source: Molecular Imaging and Biology)
Source: Molecular Imaging and Biology - June 7, 2023 Category: Molecular Biology Source Type: research
