PET Imaging of VLA-4 in a New BRAFV600E Mouse Model of Melanoma
Conclusions[64Cu]-LLP2A discriminates BPR α (VLA-4+) vs. BPR (VLA-4−) melanomasin vivo, supporting translation of these BRAF-mutated melanoma models via prospective imaging and theranostic studies. These results extend the utility of LLP2A to selectively target clinically relevant and therapy-resistant tumor variants toward its use for therapeutic patient care. (Source: Molecular Imaging and Biology)
Source: Molecular Imaging and Biology - October 25, 2021 Category: Molecular Biology Source Type: research
19F MRI Imaging Strategies to Reduce Isoflurane Artifacts in In Vivo Images
ConclusionWe optimized three easily implementable methods to avoid ISO signal artifacts and validated their performance in phantoms andin vivo. We make recommendation on the parameters that pre-clinical studies should report in their method section to make the used approach insightful. (Source: Molecular Imaging and Biology)
Source: Molecular Imaging and Biology - October 20, 2021 Category: Molecular Biology Source Type: research
Visions by WIMIN: BIPOC Representation Matters
This article focuses on the key component of representati on in the United States (U.S.), highlighting our vision for a solution for the so-called “leaky pipeline” for BIPOC in science, technology, engineering, and mathematic with action items to end it. (Source: Molecular Imaging and Biology)
Source: Molecular Imaging and Biology - October 15, 2021 Category: Molecular Biology Source Type: research
CXCR4-Directed PET/CT with [68Ga]Pentixafor in Central Nervous System Lymphoma: A Comparison with [18F]FDG PET/CT
ConclusionsCXCR4-directed PET/CT using [68 Ga]Pentixafor, with excellent tumor-to-background contrast, might be a more promising agent for the detection of lesions in CNSL patients than [18F]FDG PET/CT. (Source: Molecular Imaging and Biology)
Source: Molecular Imaging and Biology - October 14, 2021 Category: Molecular Biology Source Type: research
Improved Discrimination of Tumors with Low and Heterogeneous EGFR Expression in Fluorescence-Guided Surgery Through Paired-Agent Protocols
ConclusionThe quantitative receptor delineation of PAI promises to improve the surgical therapeutic index of cancer resection in a clinically relevant timeline. (Source: Molecular Imaging and Biology)
Source: Molecular Imaging and Biology - October 14, 2021 Category: Molecular Biology Source Type: research
Side-by-Side Comparison of uPAR-Targeting Optical Imaging Antibodies and Antibody Fragments for Fluorescence-Guided Surgery of Solid Tumors
ConclusionsIn a side-by-side comparison, FGS with uPAR-targeting antibody fragments compared with the parent IgG resulted in earlier tumor visualization at the expense of peak fluorescence intensity. (Source: Molecular Imaging and Biology)
Source: Molecular Imaging and Biology - October 12, 2021 Category: Molecular Biology Source Type: research
Identification of a Suitable Untargeted Agent for the Clinical Translation of ABY-029 Paired-Agent Imaging in Fluorescence-Guided Surgery
ConclusionPAI is a highly promising methodology for increasing detection of tumors in fluorescence-guided surgery. Although not yet clinically approved, IRDye 680LT demonstrates promise as an untargeted agent when paired with ABY-029. The clinical translation of PAI to maximize tumor excision, while minimizing normal tissue removal, could improve both patient survival and life quality. (Source: Molecular Imaging and Biology)
Source: Molecular Imaging and Biology - October 12, 2021 Category: Molecular Biology Source Type: research
Application of a Flexible PET Scanner Combined with 3 T MRI Using Non-local Means Reconstruction: Qualitative and Quantitative Comparison with Whole-Body PET/CT
ConclusionsCompared with WB PET/CT, the phantom data and image quality were inferior in fxPET. However, the results of the detection rates and quantitative values suggested the clinical feasibility of fxPET. (Source: Molecular Imaging and Biology)
Source: Molecular Imaging and Biology - October 12, 2021 Category: Molecular Biology Source Type: research
In vivo Imaging of Cannabinoid Type 2 Receptors: Functional and Structural Alterations in Mouse Model of Cerebral Ischemia by PET and MRI
ConclusionsThis study revealed an increased [18F]RoSMA-18-d6 measure of CB2R and a reduced [18F]FDG measure of CMRglc in the ischemic striatum of tMCAO mice at subacute stage. [18F]RoSMA-18-d6 might be a promising PET tracer for detecting CB2R alterations in animal models of neuroinflammation without neuronal loss. (Source: Molecular Imaging and Biology)
Source: Molecular Imaging and Biology - October 12, 2021 Category: Molecular Biology Source Type: research
Clinical Translation of Neutrophil Imaging and Its Role in Cancer
AbstractNeutrophils are the first line of defense against pathogens and abnormal cells. They regulate many biological processes such as infections and inflammation. Increasing evidence demonstrated a role for neutrophils in cancer, where different subpopulations have been found to possess both pro- or anti-tumorigenic functions in the tumor microenvironment. In this review, we discuss the phenotypic and functional diversity of neutrophils in cancer, their prognostic significance, and therapeutic relevance in human and preclinical models. Molecular imaging methods are increasingly used to probe neutrophil biologyin vivo, as...
Source: Molecular Imaging and Biology - October 12, 2021 Category: Molecular Biology Source Type: research
Comparison of Invasive and Non-invasive Estimation of [11C]PBR28 Binding in Non-human Primates
ConclusionsPopulation-based input functions scaled with a single blood sample might be a useful alternative to using AIF to compute [11C]PBR28 binding in healthy NHPs or animals with comparable metabolism and overall perform better than pseudo-reference regions approaches. (Source: Molecular Imaging and Biology)
Source: Molecular Imaging and Biology - October 7, 2021 Category: Molecular Biology Source Type: research
Sodium Pump Na + /K + ATPase Subunit α1-Targeted Positron Emission Tomography Imaging of Hepatocellular Carcinoma in Mouse Models
ConclusionsNKA α1 may serve as a suitable diagnostic biomarker for HCC.18F-ALF-NOTA-S3 shows great potential for PET imaging of HCC. (Source: Molecular Imaging and Biology)
Source: Molecular Imaging and Biology - October 7, 2021 Category: Molecular Biology Source Type: research
Image-to-Images Translation for Multiple Virtual Histological Staining of Unlabeled Human Carotid Atherosclerotic Tissue
ConclusionsThe proposed approach allows for the virtual staining of unlabeled human carotid plaque tissue images with multiple types of stains. In addition, it identifies the histopathological features of atherosclerotic plaques in the same tissue sample, which could facilitate the development of personalized prevention and other interventional treatments for carotid atherosclerosis. (Source: Molecular Imaging and Biology)
Source: Molecular Imaging and Biology - October 7, 2021 Category: Molecular Biology Source Type: research
PET/MRI and PET/CT Radiomics in Primary Cervical Cancer: A Pilot Study on the Correlation of Pelvic PET, MRI, and CT Derived Image Features
ConclusionsWe demonstrated strong correlation of many extracted radiomic features between PET/MRI and PET/CT. Eight radiomic features calculated on PET/CT and PET/MRI were significantly different between local and metastatic CCa. This study paves the way for future studies to evaluate the diagnostic and predictive potential of radiomics that could guide clinicians toward personalized patients care. (Source: Molecular Imaging and Biology)
Source: Molecular Imaging and Biology - October 7, 2021 Category: Molecular Biology Source Type: research
Amyloid- β PET Classification on Cognitive Aging Stages Using the Centiloid Scale
ConclusionSuperAgers exhibited a similar A β load to AC and MC, differing in cognitive performance. Independently of cut-point used (10 CL, 19 CL, or 30 CL), three SA individuals were classified as Aβ positive, showing the duality between the individual’s clinics and the biological definition of Alzheimer’s. Different cut-points lead t o Aβ positivity classification mismatch in individuals, and an extra care is needed for individuals who have a CL value between 10 and 30 CL. (Source: Molecular Imaging and Biology)
Source: Molecular Imaging and Biology - October 5, 2021 Category: Molecular Biology Source Type: research
