PET Imaging of VLA-4 in a New BRAFV600E Mouse Model of Melanoma

Conclusions[64Cu]-LLP2A discriminates BPR α (VLA-4+) vs. BPR (VLA-4−) melanomasin vivo, supporting translation of these BRAF-mutated melanoma models via prospective imaging and theranostic studies. These results extend the utility of LLP2A to selectively target clinically relevant and therapy-resistant tumor variants toward its use for therapeutic patient care.
Source: Molecular Imaging and Biology - Category: Molecular Biology Source Type: research