The Performance Comparison of 18F-FDG PET/MRI and 18F-FDG PET/CT for the Identification of Pancreatic Neoplasms
ConclusionsIn this study, we found PET/MRI and PET/CT, both using18F-FDG as tracer, had comparable overall performance in identification of pancreatic neoplasms. Interestingly, for patients who had suspected pancreatic neoplasm but invisible FDG uptake, PET/MRI had shown exceptionally better performance, probably because MR images could detect tiny abnormal structures to improve diagnosis. (Source: Molecular Imaging and Biology)
Source: Molecular Imaging and Biology - March 24, 2022 Category: Molecular Biology Source Type: research
Impact of Tumor Burden on Normal Organ Distribution in Patients Imaged with CXCR4-Targeted [68Ga]Ga-PentixaFor PET/CT
ConclusionsIn patients with solid tumors imaged with [68Ga]Ga-PentixaFor PET/CT, no relevant tumor sink effect was noted. This observation may be of relevance for therapies with radioactive and non-radioactive CXCR4-directed drugs, as with increasing tumor burden, the dose to normal organs may remain unchanged. (Source: Molecular Imaging and Biology)
Source: Molecular Imaging and Biology - March 21, 2022 Category: Molecular Biology Source Type: research
Fully Integrated Ultra-thin Intraoperative Micro-imager for Cancer Detection Using Upconverting Nanoparticles
ConclusionThe imaging system proposed here is a scalable chip-scale ultra-thin alternative for bulky conventional intraoperative imagers. Its novel pixel architecture and background correction scheme enable visualization of microscopic-scale residual disease while remaining completely free of lenses and filters, achieving an ultra-miniaturized form factor —critical for intraoperative settings. (Source: Molecular Imaging and Biology)
Source: Molecular Imaging and Biology - March 21, 2022 Category: Molecular Biology Source Type: research
Editorial to the Special Issue Entitled “Imaging in Immunooncology”
(Source: Molecular Imaging and Biology)
Source: Molecular Imaging and Biology - March 18, 2022 Category: Molecular Biology Source Type: research
Evaluation of [18F]F-DPA PET for Detecting Microglial Activation in the Spinal Cord of a Rat Model of Neuropathic Pain
Conclusions[18F]F-DPA aided visualization of the spinal cord inflammation site in PSNL rats onex vivo autoradiography and was superior to [11C]PK11195.In vivo [18F]F-DPA PET did not allow for visualization of tracer accumulation even using a high-spatial-resolution PET scanner. The main reason for this result was due to insufficient SUVs in the spinal cord region as compared with the background noise, in addition to a spillover from the vertebral body. (Source: Molecular Imaging and Biology)
Source: Molecular Imaging and Biology - March 18, 2022 Category: Molecular Biology Source Type: research
Visions by WIMIN: Global Mentorship to Retain Underrepresented Trainees
AbstractMentorship is a fundamental aspect that contributes to the success of a career in science, technology, engineering, and mathematics (STEM), particularly in academia. Research suggests that underrepresented minorities (URMs) often experience less quality mentorship and face barriers to finding successful mentor –mentee relationships. URM trainees in STEM face challenges that are not encountered by their majority peers or mentors, adding another level of complexity to establishing important relationships. Mentors of URM trainees must therefore mentor beyond general scientific training and tailor their men torship t...
Source: Molecular Imaging and Biology - March 17, 2022 Category: Molecular Biology Source Type: research
Effects of Light-absorbing Carbons in Intraoperative Molecular Imaging –Guided Lung Cancer Resections
ConclusionSmokers with greater than 10 PPY and those with chronic lung disease appear to have decreased lesion-to-background discrimination, significant anthracosis, and reduced IMI efficacy secondary to light-absorbing carbon deposition. (Source: Molecular Imaging and Biology)
Source: Molecular Imaging and Biology - March 15, 2022 Category: Molecular Biology Source Type: research
The Need to Pair Molecular Monitoring Devices with Molecular Imaging to Personalize Health
AbstractBy enabling the non-invasive monitoring and quantification of biomolecular processes, molecular imaging has dramatically improved our understanding of disease. In recent years, non-invasive access to the molecular drivers of healthversus disease has emboldened the goal of precision health, which draws on concepts borrowed from process monitoring in engineering, wherein hundreds of sensors can be employed to develop a model which can be used to preventatively detect and diagnose problems. In translating this monitoring regime from inanimate machines to human beings, precision health posits that continual and on-the-...
Source: Molecular Imaging and Biology - March 7, 2022 Category: Molecular Biology Source Type: research
Training on Reporting and Data System (RADS) for Somatostatin-Receptor Targeted Molecular Imaging Can Reduce the Test Anxiety of Inexperienced Readers
ConclusionsA framework-focused reader training can reduce anxiety to report on SSTR-PET/CTs, in particular for inexperienced readers. This may allow for a more widespread adoption of this system, e.g., in multicenter trials for better intra- and interindividual comparison of scan results. (Source: Molecular Imaging and Biology)
Source: Molecular Imaging and Biology - March 1, 2022 Category: Molecular Biology Source Type: research
Heterodimeric RGD-NGR PET Tracer for the Early Detection of Pancreatic Cancer
ConclusionThe proposed RGD-NGR heterodimer possesses the potential to be applied in the PDAC early detection for high-risk populations. (Source: Molecular Imaging and Biology)
Source: Molecular Imaging and Biology - February 28, 2022 Category: Molecular Biology Source Type: research
Publisher Correction: Development of Duramycin-Based Molecular Probes for Cell Death Imaging
(Source: Molecular Imaging and Biology)
Source: Molecular Imaging and Biology - February 22, 2022 Category: Molecular Biology Source Type: research
Correction: Optimisation of the Synthesis and Cell Labelling Conditions for [89Zr]Zr-oxine and [89Zr]Zr-DFO-NCS: a Direct In Vitro Comparison in Cell Types with Distinct Therapeutic Applications
(Source: Molecular Imaging and Biology)
Source: Molecular Imaging and Biology - February 16, 2022 Category: Molecular Biology Source Type: research
Activity Dose Reduction in 64Cu-DOTATATE PET in Patients with Neuroendocrine Neoplasms: Impact on Image Quality and Lesion Detection Ability
ConclusionsThe [64Cu]Cu-DOTATATE activity dose can be reduced from 191 MBq to at least 142 MBq without losing image quality or lesion detection ability and further reduced to 95 MBq without loss of clinically relevant information. (Source: Molecular Imaging and Biology)
Source: Molecular Imaging and Biology - February 15, 2022 Category: Molecular Biology Source Type: research
EGFR-Targeted ImmunoPET of UMUC3 Orthotopic Bladder Tumors
ConclusionThe preclinical data presents a proof of concept for utilizing EGFR-targeted immunoPET to image BCa with altered EGFR protein levels. (Source: Molecular Imaging and Biology)
Source: Molecular Imaging and Biology - February 11, 2022 Category: Molecular Biology Source Type: research
A Human-derived Dual MRI/PET Reporter Gene System with High Translational Potential for Cell Tracking
ConclusionsOur study demonstrates the ability to noninvasively track cells engineered with our human-derived dual MRI/PET reporter system, enabling a more comprehensive evaluation of transplanted cells. Future work is focused on applying this tool to track therapeutic cells, which may one day enable the broader application of cell tracking within the healthcare system. (Source: Molecular Imaging and Biology)
Source: Molecular Imaging and Biology - February 10, 2022 Category: Molecular Biology Source Type: research
