Quantitative and Qualitative Assessment of Urinary Activity of 18F-Flotufolastat-PET/CT in Patients with Prostate Cancer: a Post Hoc Analysis of the LIGHTHOUSE and SPOTLIGHT Studies
Conclusions18F-Flotufolastat urinary activity did not influence disease assessment for the majority of patients. While this study was not designed as a head-to-head comparison, the median bladder SUVs are lower than previously reported values for other renally cleared PSMA-PET radiopharmaceuticals. (Source: Molecular Imaging and Biology)
Source: Molecular Imaging and Biology - November 6, 2023 Category: Molecular Biology Source Type: research
Image Denoising of Low-Dose PET Mouse Scans with Deep Learning: Validation Study for Preclinical Imaging Applicability
ConclusionVisual and quantitative results support the superior performance and robustness in image denoising of the implemented DL models for low statistics micro-PET. This offers much more flexibility in optimizing preclinical, longitudinal imaging protocols with reduced tracer doses or shorter durations. (Source: Molecular Imaging and Biology)
Source: Molecular Imaging and Biology - October 24, 2023 Category: Molecular Biology Source Type: research
Toward a Nanoencapsulated EPR Imaging Agent for Clinical Use
ConclusionsA novel encapsulated nanoparticle EPR imaging agent has been described which could be used in the future to bring EPR imaging for guidance of radiotherapy into clinical reality. (Source: Molecular Imaging and Biology)
Source: Molecular Imaging and Biology - October 23, 2023 Category: Molecular Biology Source Type: research
Sub-Chronic Ketamine Administration Increases Dopamine Synthesis Capacity in the Mouse Midbrain: a Preclinical In Vivo PET Study
ConclusionsUsing this optimised method for quantifying18F-DOPA uptake in the midbrain, we found that elevated striatal DA synthesis capacity in the sub-chronic ketamine model extends to the midbrain. Interestingly, the dysconnectivity between the midbrain and striatum seen in this model is also evident in the clinical population. This model may therefore be ideal for assessing novel compounds which are designed to modulate pre-synaptic DA synthesis capacity. (Source: Molecular Imaging and Biology)
Source: Molecular Imaging and Biology - October 23, 2023 Category: Molecular Biology Source Type: research
Assessment of Brain Tumour Perfusion Using Early-Phase 18F-FET PET: Comparison with Perfusion-Weighted MRI
ConclusionEarly18F-FET maps (0 –2 min p.i.) in gliomas provide similar information to MR-rCBV maps and may be helpful when PWI is not possible or available. Further studies in gliomas are needed to evaluate whether18F-FET-rCBV provides the same clinical information as MR-rCBV. (Source: Molecular Imaging and Biology)
Source: Molecular Imaging and Biology - October 17, 2023 Category: Molecular Biology Source Type: research
Alpha Particle –Emitting Radiopharmaceuticals as Cancer Therapy: Biological Basis, Current Status, and Future Outlook for Therapeutics Discovery
AbstractCritical advances in radionuclide therapy have led to encouraging new options for cancer treatment through the pairing of clinically useful radiation-emitting radionuclides and innovative pharmaceutical discovery. Of the various subatomic particles used in therapeutic radiopharmaceuticals, alpha (α) particles show great promise owing to their relatively large size, delivered energy, finite pathlength, and resulting ionization density. This review discusses the therapeutic benefits ofα-emitting radiopharmaceuticals and their pairing with appropriate diagnostics, resulting in innovative “theranostic” platforms....
Source: Molecular Imaging and Biology - October 16, 2023 Category: Molecular Biology Source Type: research
Imaging Reactive Oxygen Radicals in Excised Mouse Lung Trapped by Reaction with Hydroxylamine Probes Using 1 GHz Rapid Scan Electron Paramagnetic Resonance
ConclusionThe nitroxide radicals in excised mouse lungs formed by reaction with hydroxylamine probes CPH and DCP-AM-H can be imaged at 1 GHz. (Source: Molecular Imaging and Biology)
Source: Molecular Imaging and Biology - October 11, 2023 Category: Molecular Biology Source Type: research
Parametric Imaging of P-Glycoprotein Function at the Blood –Brain Barrier Using kE,brain-maps Generated from [11C]Metoclopramide PET Data in Rats, Nonhuman Primates and Humans
ConclusionskE,brain of [11C]metoclopramide provides a simple outcome parameter to describe P-gp function in the living brain when arterial input function data are unavailable, although less sensitive thanVT.kE,brain-maps represent easy to compute parametric images reflecting the effect of P-gp on [11C]metoclopramide elimination from the brain. (Source: Molecular Imaging and Biology)
Source: Molecular Imaging and Biology - October 6, 2023 Category: Molecular Biology Source Type: research
Magnetic Particle Imaging-Guided Hyperthermia for Precise Treatment of Cancer: Review, Challenges, and Prospects
AbstractMagnetic particle imaging (MPI) is a novel quantitative imaging technique using the nonlinear magnetization behavior of magnetic nanoparticles (MNPs) to determine their local concentration. Magnetic fluid hyperthermia (MFH) is a promising non-invasive therapy using the heating effects of MNPs. MPI-MFH is expected to enable real-time MPI guidance, localized MFH, and non-invasive temperature monitoring, which shows great potential for precise treatment of cancer. In this review, we introduce the fundamentals of MPI and MFH and their applications in the treatment of cancer. Also, we discuss the challenges and prospect...
Source: Molecular Imaging and Biology - October 3, 2023 Category: Molecular Biology Source Type: research
Correction: High Vascular Delivery of EGF, but Low Receptor Binding Rate Is Observed in AsPC-1 Tumors as Compared to Normal Pancreas
(Source: Molecular Imaging and Biology)
Source: Molecular Imaging and Biology - October 3, 2023 Category: Molecular Biology Source Type: research
Pulse and CW EPR Oximetry Using Oxychip in Gemcitabine-Treated Murine Pancreatic Tumors
ConclusionsBoth techniques offer fast and reliable oximetry in vivo, allowing to follow the effects of pharmaceutic intervention. (Source: Molecular Imaging and Biology)
Source: Molecular Imaging and Biology - October 2, 2023 Category: Molecular Biology Source Type: research
Urokinase-Type Plasminogen Activator Receptor (uPAR) Expression and [64Cu]Cu-DOTA-AE105 uPAR-PET/CT in Patient-Derived Xenograft Models of Oral Squamous Cell Carcinoma
ConclusionsOSCC PDX models in early passages histologically mimic donor tumors and could serve as a valuable platform for the development of uPAR-targeted imaging and therapeutic modalities. Furthermore, [64Cu]Cu-uPAR-PET/CT showed target- and tumor-specific uptake in OSCC PDX models demonstrating the diagnostic potential of this modality for OSCC patients. (Source: Molecular Imaging and Biology)
Source: Molecular Imaging and Biology - September 25, 2023 Category: Molecular Biology Source Type: research
Development and Initial Assessment of [18F]OP-801: a Novel Hydroxyl Dendrimer PET Tracer for Preclinical Imaging of Innate Immune Activation in the Whole Body and Brain
Conclusion[18F]OP-801 is a promising new PET tracer for sensitive and specific detection of activated macrophages and microglia that warrants further investigation. (Source: Molecular Imaging and Biology)
Source: Molecular Imaging and Biology - September 21, 2023 Category: Molecular Biology Source Type: research
Evaluating Tumor Hypoxia Radiosensitization Via Electron Paramagnetic Resonance Oxygen Imaging (EPROI)
ConclusionEPROI provides 3D high-resolution pO2 quantification; EPR is better suited than DRS to characterize tumor hypoxia. PPV did not radiosensitize E0771 tumors nor p53/MCA sarcomas, which may be related to the complex pattern of vasculature in each tumor. Additionally, understanding model-dependent tumor hypoxia will provide a much-needed foundation for future therapeutic studies with hypoxic radiosensitizers. (Source: Molecular Imaging and Biology)
Source: Molecular Imaging and Biology - September 18, 2023 Category: Molecular Biology Source Type: research
Use of Magnetotactic Bacteria as an MRI Contrast Agent for In Vivo Tracking of Adoptively Transferred Immune Cells
ConclusionsCells can be labeled with sufficient numbers of MEs to be detectable with MRI without compromising cell viability. Care must be taken at higher concentrations of MEs, which may affect some cell types ’ functional activity and/or morphology. Immune cells with minimal phagocytic behavior have much lower iron content per cell after incubation with MEs vs SPIO; however, MEs can successfully be used as a contrast agent for phagocytic immune cells. (Source: Molecular Imaging and Biology)
Source: Molecular Imaging and Biology - September 15, 2023 Category: Molecular Biology Source Type: research
