Journal of NeuroImmune Pharmacology This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Immunoproteasome Inhibitor ONX-0914 Affects Long-Term Potentiation in Murine Hippocampus
(Source: Journal of NeuroImmune Pharmacology)
Source: Journal of NeuroImmune Pharmacology - January 6, 2021 Category: Drugs & Pharmacology Source Type: research

Pharmacotherapeutics of SARS-CoV-2 Infections
AbstractThe COVID-19 pandemic has affected more than 38 million people world-wide by person to person transmission of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Therapeutic and preventative strategies for SARS-CoV-2 remains a significant challenge. Within the past several months, effective treatment options have emerged and now include repurposed antivirals, corticosteroids and virus-specific antibodies. The latter has included convalescence plasma and monoclonal antibodies. Complete viral eradication will be achieved through an effective, safe and preventative vaccine. To now provide a comprehensive...
Source: Journal of NeuroImmune Pharmacology - January 6, 2021 Category: Drugs & Pharmacology Source Type: research

Is COVID-19 Gender-sensitive?
AbstractWhile clinical characteristics exhibit that susceptibility to COVID-19 infection is equally likely between males and females, clinical outcomes show that males experience both a higher severity and fatality for COVID-19 infection than females. This review examines the evidence for these sex and gender differences and aims to illustrate possible mechanisms behind such sensitivity. Successful entry of SARS-CoV-2 into the body is dependent on the angiotensin-converting enzyme 2 (ACE2) receptor and the transmembrane protease serine 2 (TMPRSS2). Thus, sex-based differences in the expression of the ACE2 receptor and TMPR...
Source: Journal of NeuroImmune Pharmacology - January 6, 2021 Category: Drugs & Pharmacology Source Type: research

SARS-COV2 Alters Blood Brain Barrier Integrity Contributing to Neuro-Inflammation
(Source: Journal of NeuroImmune Pharmacology)
Source: Journal of NeuroImmune Pharmacology - January 6, 2021 Category: Drugs & Pharmacology Source Type: research

Correction to: Can Cytokine Blocking Prevent Depression in COVID-19 Survivors?
A correction to this paper has been published:https://doi.org/10.1007/s11481-020-09977-w (Source: Journal of NeuroImmune Pharmacology)
Source: Journal of NeuroImmune Pharmacology - January 4, 2021 Category: Drugs & Pharmacology Source Type: research

Kynurenic Acid Protects Against Reactive Glial-associated Reductions in the Complexity of Primary Cortical Neurons
AbstractBrain glia produce neuroactive metabolites via tryptophan-kynurenine catabolism. A role for kynurenine pathway (KP) metabolites is proposed in reactive glial associated neurodegeneration. The aim of this investigation was to assess the role of KP induction and KP metabolites in driving reactive glial associated neuronal atrophy. Rat primary mixed glia, and enriched microglial and astroglial cultures were stimulated with IFN γ (10 ng/ml) for 24 hours. KP induction in mixed glial cells was confirmed by raised expression of the rate limiting KP enzyme indoleamine 2,3 dioxygenase (IDO) and raised concentrations of KP...
Source: Journal of NeuroImmune Pharmacology - January 3, 2021 Category: Drugs & Pharmacology Source Type: research

Brain Selective Estrogen Treatment Protects Dopaminergic Neurons and Preserves Behavioral Function in MPTP-induced Mouse Model of Parkinson ’s Disease
In conclusions, our findings suggest that DHED protects dopaminergic neurons from MPTP toxicity in mouse model of PD and support a beneficial effect of brain-selective estrogen in attenuating neuro degeneration and motor symptoms in PD-related neurological disorders.Graphical Abstract (Source: Journal of NeuroImmune Pharmacology)
Source: Journal of NeuroImmune Pharmacology - November 22, 2020 Category: Drugs & Pharmacology Source Type: research

IMT504 Provides Analgesia by Modulating Cell Infiltrate and Inflammatory Milieu in a Chronic Pain Model
AbstractIMT504 is a non-CPG, non-coding synthetic oligodeoxinucleotide (ODN) with immunomodulatory properties and a novel inhibitory role in pain transmission, exerting long-lasting analgesic effects upon multiple systemic administrations. However, its mechanisms of anti-nociceptive action are still poorly understood. In the present study in male adult rats undergoing complete Freund ’s adjuvant-induced hindpaw inflammation, we focused in the analysis of the immunomodulatory role of IMT504 over the cellular infiltrate, the impact on the inflammatory milieu, and the correlation with its anti-allodynic role. By means of be...
Source: Journal of NeuroImmune Pharmacology - November 21, 2020 Category: Drugs & Pharmacology Source Type: research

An Investigation into Proteomic Constituents of Cerebrospinal Fluid in Patients with Chronic Peripheral Neuropathic Pain Medicated with Opioids- a Pilot Study
This study suggests modulation of CNS homeostasis, possibly attributable to opioids, thus highlighting potential mechanisms for the pharmacodynamics of opioids. We also provide new insights into the immunomodulatory fu nctions of opioids in vivo. (Source: Journal of NeuroImmune Pharmacology)
Source: Journal of NeuroImmune Pharmacology - November 20, 2020 Category: Drugs & Pharmacology Source Type: research

Unraveling neuroHIV in the Presence of Substance Use Disorders
AbstractThis special issue contains 10 invited review papers that highlighted and extended the presentations at the NIDA-sponsored workshop “Unraveling NeuroAIDS in the Presence of Substance Use Disorders ” at the 25th Society on NeuroImmune Pharmacology conference in 2019. The topics covered by these papers focused on the interactive, additive or synergistic effects of substance use disorders (SUD) with HIV infection on the immune system and on  neuropathogenesis. These papers reviewed four categories of substances of abuse (opioids, tobacco, stimulants, and cannabis) and how comorbid HIV infection (including models ...
Source: Journal of NeuroImmune Pharmacology - November 20, 2020 Category: Drugs & Pharmacology Source Type: research

Human Amniotic Epithelial Cells Alleviate a Mouse Model of Parkinson ’s Disease Mainly by Neuroprotective, Anti-Oxidative and Anti-Inflammatory Factors
AbstractHuman amniotic epithelial cells (hAECs) have been reported to have neuroprotective roles in Parkinson ’s disease (PD) animal models. However, the molecular mechanism is not fully understood. The present study was designed to explore the possible mechanism by which hAECs ameliorate PD symptoms and the important paracrine factors produced by hAECs that attribute to the recovery of dopaminergic neuro ns. Thus, we performed in vivo and in vitro experiments with hAECs in PD models or lesioned dopaminergic neurons, respectively. First, hAECs were transplanted into the striatum of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyr...
Source: Journal of NeuroImmune Pharmacology - November 9, 2020 Category: Drugs & Pharmacology Source Type: research

Emerging Role of Nef in the Development of HIV Associated Neurological Disorders
AbstractDespite adherence to treatment, individuals living with HIV have an increased risk for developing cognitive impairments, referred to as HIV-associated neurological disorders (HAND). Due to continued growth in the HIV population, particularly amongst the aging cohort, the neurobiological mechanisms of HAND are increasingly relevant. Similar to other viral proteins (e.g. Tat, Gp120, Vpr), the Negative Factor (Nef) is associated with numerous adverse effects in the CNS as well as cognitive impairments. In particular, emerging data indicate the consequences of Nef may be facilitated by the modulation of cellular autoph...
Source: Journal of NeuroImmune Pharmacology - October 29, 2020 Category: Drugs & Pharmacology Source Type: research

Correction to: Platelet-Derived Growth Factor-BB Restores HIV Tat-Mediated Impairment of Neurogenesis: Role of GSK-3 β/β-Catenin
We have now noticed that that the wrong western blot images of GSK-3 β was inadvertently included in Fig. 4C. (Source: Journal of NeuroImmune Pharmacology)
Source: Journal of NeuroImmune Pharmacology - October 28, 2020 Category: Drugs & Pharmacology Source Type: research

Independent and Combined Effects of Nicotine or Chronic Tobacco Smoking and HIV on the Brain: A Review of Preclinical and Clinical Studies
AbstractTobacco smoking is highly prevalent among HIV-infected individuals. Chronic smokers with HIV showed greater cognitive deficits and impulsivity, and had more psychopathological symptoms and greater neuroinflammation than HIV non-smokers or smokers without HIV infection. However, preclinical studies that evaluated the combined effects of HIV-infection and tobacco smoking are scare. The preclinical models typically used cell cultures or animal models that involved specific HIV viral proteins or the administration of nicotine to rodents. These preclinical models consistently demonstrated that nicotine had neuroprotecti...
Source: Journal of NeuroImmune Pharmacology - October 27, 2020 Category: Drugs & Pharmacology Source Type: research

Can Cytokine Blocking Prevent Depression in COVID-19 Survivors?
(Source: Journal of NeuroImmune Pharmacology)
Source: Journal of NeuroImmune Pharmacology - October 26, 2020 Category: Drugs & Pharmacology Source Type: research