Journal of NeuroImmune Pharmacology 
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This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.The Role of Cannabis, Cannabidiol and Other Cannabinoids in Chronic Pain. The Perspective of Physicians
AbstractCurrently, there is a renewed interest in treatments with medical cannabis and cannabinoids. Based on an increasing number of publications over the last decades that permitted new insights into mechanisms, efficacy and safety of cannabinoids, the use of cannabinergic medications is authorised in an increasing number of European and non-European countries. The alleviation of chronic, painful conditions is, since thousands of years, one of the primary reasons for the use of cannabis. Depending on the country, a wide range of medicinal cannabis preparations are available:ranging from defined cultivars of medical canna...
Source: Journal of NeuroImmune Pharmacology - August 31, 2021 Category: Drugs & Pharmacology Source Type: research
Oral Enrichment of Streptococcus and its Role in Systemic Inflammation Related to Monocyte Activation in Humans with Cocaine Use Disorder
This study revealed that chronic cocaine use-associated inflammation in the blood may result from increased oralStreptococcus and its effects on myeloid cell activation, but does not result from cocaine directly.Graphical abstract (Source: Journal of NeuroImmune Pharmacology)
Source: Journal of NeuroImmune Pharmacology - August 26, 2021 Category: Drugs & Pharmacology Source Type: research
Extracellular Microvesicles Released From Brain Endothelial Cells are Detected in Animal Models Of HIV-1 Signifying Unresolved Inflammation
AbstractTreatment of HIV-infected patients with antiretroviral therapy (ART) has effectively suppressed viral replication; however, the central nervous system is still a major target and reservoir of the virus leading to the possible development of HIV-associated neurocognitive disorders (HAND). Furthermore, a hallmark feature of HAND is the disruption of the blood –brain barrier that leads to loss of tight junction protein (TJP) complexes. Extracellular vesicles (EVs), released by every cell type in the body, occur in greater quantities in response to cellular activation or injury. We have found that inflammatory insult...
Source: Journal of NeuroImmune Pharmacology - August 26, 2021 Category: Drugs & Pharmacology Source Type: research
Interactive Effects of HIV Infection and Cannabis Use on Insula Subregion Functional Connectivity
AbstractChronic inflammation in the central nervous system is one mechanism through which human immunodeficiency virus (HIV) may lead to progressive cognitive decline. Given cannabis ’s (CB’s) anti-inflammatory properties, use prevalence among people living with HIV (PLWH), and evidence implicating the insula in both, we examined independent and interactive effects of HIV and CB on insular circuitry, cognition, and immune function. We assessed resting-state functional connec tivity (rsFC) of three insula subregions among 106 participants across four groups (co-occurring: HIV+/CB+;HIV –only: HIV+/CB −;CB –only: HI...
Source: Journal of NeuroImmune Pharmacology - August 24, 2021 Category: Drugs & Pharmacology Source Type: research
Investigating Neurological Manifestations of SARS-CoV-2
(Source: Journal of NeuroImmune Pharmacology)
Source: Journal of NeuroImmune Pharmacology - August 24, 2021 Category: Drugs & Pharmacology Source Type: research
Modulation of OPRM1 Alternative Splicing by Morphine and HIV –1 Nef
AbstractClinically used opioids, such as morphine, activate the mu opioid receptor (MOR) encoded by Opioid Receptor Mu 1 (OPRM1) gene. Examination of the opioid receptor genes showed that the human OPRM1 pre –mRNA undergoes extensive alternative splicing events and capable of expressing 21 isoforms. However, characterization of OPRM1 signaling is generalized, and only one isoform (MOR–1) has been extensively studied. Compounding this issue is the increasing significance of intravenous drug abuse in HIV neuropathogenesis. Here, we investigated the molecular impact of morphine and HIV–1 on regulation of OPRM1 pre–mRN...
Source: Journal of NeuroImmune Pharmacology - August 21, 2021 Category: Drugs & Pharmacology Source Type: research
Can FDA-Approved Immunomodulatory Drugs be Repurposed/Repositioned to Alleviate Chronic Pain?
AbstractPain is among the most widespread chronic health condition confronting society today and our inability to manage chronic pain contributes to the opioid abuse epidemic in America. The immune system is known to contribute to acute and chronic pain, but only limited therapeutic treatments such as non-steroid anti-inflammatory drugs have resulted from this knowledge. The last decade has shed light on neuro-immune interactions mediating the development, maintenance, and resolution of chronic pain. Here, we do not aim to perform a comprehensive review of all immune mechanisms involved in chronic pain, but to briefly revi...
Source: Journal of NeuroImmune Pharmacology - August 9, 2021 Category: Drugs & Pharmacology Source Type: research
The Symptoms and Clinical Manifestations Observed in COVID-19 Patients/Long COVID-19 Symptoms that Parallel Toxoplasma gondii Infections
(Source: Journal of NeuroImmune Pharmacology)
Source: Journal of NeuroImmune Pharmacology - August 9, 2021 Category: Drugs & Pharmacology Source Type: research
Coronavirus Disease-19 Vaccines Best Reflect Effective Pharmaceuticals
(Source: Journal of NeuroImmune Pharmacology)
Source: Journal of NeuroImmune Pharmacology - August 9, 2021 Category: Drugs & Pharmacology Source Type: research
Dexmedetomidine Restores Autophagic Flux, Modulates Associated microRNAs and the Cholinergic Anti-inflammatory Pathway upon LPS-Treatment in Rats
AbstractInfections and perioperative stress can lead to neuroinflammation, which in turn is linked to cognitive impairments such as postoperative delirium or postoperative cognitive dysfunctions. The α2-adrenoceptor agonist dexmedetomidine (DEX) prevents cognitive impairments and has organo-protective and anti-inflammatory properties. Macroautophagy (autophagy) regulates many biological processes, but its role in DEX-mediated anti-inflammation and the underlying mechanism of DEX remains largely unclear. We were interested how a pretreatment with DEX protects against lipopolysaccharide (LPS)-induced inflammation in adult m...
Source: Journal of NeuroImmune Pharmacology - August 6, 2021 Category: Drugs & Pharmacology Source Type: research
Suppression of HIV-associated Macrophage Activation by a p75 Neurotrophin Receptor Ligand
AbstractPrevious studies indicated that nerve growth factor (NGF) and proNGF differentially regulate the phenotype of macrophages and microglia via actions at tropomyosin receptor kinase A (TrkA) and p75 neurotrophin receptors (p75NTR), respectively. The ability of HIV gp120 and virions to induce the secretion of factors toxic to neurons was suppressed by NGF and enhanced by proNGF, suggesting the potential for neurotrophin based “anti-inflammatory” interventions. To investigate the “anti-inflammatory” potential of the p75NTR ligand, LM11A-31, we treated cultured macrophages and microglia with HIV gp120 in the pres...
Source: Journal of NeuroImmune Pharmacology - July 22, 2021 Category: Drugs & Pharmacology Source Type: research
Society on NeuroImmune Pharmacology COVID-19 Virtual Workshop
AbstractThis brief report collects the program and abstracts of the Society on NeuroImmune Pharmacology (SNIP) COVID-19 Virtual Workshop held on April 9, 2021. The workshop consisted of four symposia: Symposium 1: Molecular approaches to COVID-19 pathogenesis and underlying mechanisms; Symposium 2: Therapeutic and vaccine approaches to COVID-19; Symposium 3: Early Career Investigator talks; and Symposium 4: Diversity and Inclusion SNIP Committee (DISC) program: Well-being and reflections. The workshop also featured four special talks on COVID-19 and funding opportunities from the National Institute on Alcohol Abus...
Source: Journal of NeuroImmune Pharmacology - June 28, 2021 Category: Drugs & Pharmacology Source Type: research
Correction to: Glutamine Antagonist JHU083 Normalizes Aberrant Glutamate Production and Cognitive Deficits in the EcoHIV Murine Model of HIV-Associated Neurocognitive Disorders
A correction to this paper has been published: https://doi.org/10.1007/s11481-021-09992-5 (Source: Journal of NeuroImmune Pharmacology)
Source: Journal of NeuroImmune Pharmacology - April 29, 2021 Category: Drugs & Pharmacology Source Type: research
Agathisflavone Modifies Microglial Activation State and Myelination in Organotypic Cerebellar Slices Culture
AbstractOligodendrocytes produce the myelin that is critical for rapid neuronal transmission in the central nervous system (CNS). Disruption of myelin has devastating effects on CNS function, as in the demyelinating disease multiple sclerosis (MS). Microglia are the endogenous immune cells of the CNS and play a central role in demyelination and repair. There is a need for new potential therapies that regulate myelination and microglia to promote repair. Agathisflavone (FAB) is a non-toxic flavonoid that is known for its anti-inflammatory and neuroprotective properties. Here, we examined the effects of FAB (5-50 μM) on mye...
Source: Journal of NeuroImmune Pharmacology - April 21, 2021 Category: Drugs & Pharmacology Source Type: research
Different Susceptibility of T and B Cells to Cladribine Depends On Their Levels of Deoxycytidine Kinase Activity Linked to Activation Status
AbstractDeoxycytidine kinase (dCK) and 5 ’ deoxynucleotidase (NT5C2) are involved in metabolism of cladribine (2CdA), the immunomodulatory drug for multiple sclerosis; by mediating phosphorylation (activation) or phosphorolysis (deactivation) of 2CdA, respectively, these enzymes promote or prevent its accumulation in the cell, which lead s to cell death. In particular, lymphocytes which present with a high intracellular dCK/NT5C2 ratio are more sensitive to 2CdA than other immune cells. We aim at determining if the expression of these enzymes and/or their activity differ in specific progenitor and mature immune cells and...
Source: Journal of NeuroImmune Pharmacology - April 14, 2021 Category: Drugs & Pharmacology Source Type: research
