Journal of NeuroImmune Pharmacology This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Integrase Inhibitors are Associated with Neuropsychiatric Symptoms in Women with HIV
AbstractObjectiveWomen with HIV(WWH) are more likely to discontinue/change antiretroviral therapy(ART) due to side effects including neuropsychiatric symptoms. Efavirenz and integrase strand transfer inhibitors(INSTIs) are particularly concerning. We focused on these ART agents and neuropsychiatric symptoms in previously developed subgroups of WWH that differed on key sociodemographic factors as well as longitudinal behavioral and clinical profiles.  WWH from the Women’s Interagency HIV Study were included if they had ART data available, completed the Perceived Stress Scale-10 and PTSD Checklist-Civilian. Questionnaires...
Source: Journal of NeuroImmune Pharmacology - February 17, 2022 Category: Drugs & Pharmacology Source Type: research

Chronic Morphine Induces IL-18 in Ileum Myenteric Plexus Neurons Through Mu-opioid Receptor Activation in Cholinergic and VIPergic Neurons
In conclusion, these data show that morphine increases IL-18 in ileum myenteric plexus neurons via activation of MORs in a subset of cholinergic and VIP neurons. Thus, understanding the neurochemistry and electrophysiology of MOR-expressing enteric neurons can help to delineate mechanisms by which morphine perturbs the gut barrier.Graphic Abstract (Source: Journal of NeuroImmune Pharmacology)
Source: Journal of NeuroImmune Pharmacology - February 2, 2022 Category: Drugs & Pharmacology Source Type: research

Vancomycin Pretreatment on MPTP-Induced Parkinson ’s Disease Mice Exerts Neuroprotection by Suppressing Inflammation Both in Brain and Gut
In this study, vancomycin pretreatment was given by gavage once daily with either vanc omycin or distilled water for 14 days to mice, then mice were administered with MPTP (20 mg/kg, i.p) for four times in one day to establish an acute PD model. Results show that vancomycin pretreatment significantly improved motor dysfunction of mice in pole and traction tests. Although vancomycin  pretreatment had no effect on dopamine (DA) or the process of DA synthesis, it inhibited the metabolism of DA by suppressing the expression of striatal monoamine oxidase B (MAO-B). Furthermore, vancomycin pretreatment reduced the number of a...
Source: Journal of NeuroImmune Pharmacology - January 29, 2022 Category: Drugs & Pharmacology Source Type: research

A direct interaction between RhoGDI α/Tau alleviates hyperphosphorylation of Tau in Alzheimer's disease and vascular dementia
AbstractRhoGDI α is an inhibitor of RhoGDP dissociation that involves in Aβ metabolism and NFTs production in Alzheimer's disease (AD) by regulating of RhoGTP enzyme activity. Our previous research revealed that RhoGDIα, as the target of Polygala saponin (Sen), might alleviate apoptosis of the nerve cells cause d by hypoxia/reoxygenation (H/R). To further clarify the role of RhoGDIα in the generation of NFTs, we explored the relationship between RhoGDIα and Tau. We found out that RhoGDIα and Tau can bind with each other and interact by using coimmunoprecipitation (Co-IP) and GST pulldown methods in vitr o. This RhoGD...
Source: Journal of NeuroImmune Pharmacology - January 26, 2022 Category: Drugs & Pharmacology Source Type: research

Effects of Morphine on Gp120-induced Neuroinflammation Under Immunocompetent Vs. Immunodeficient Conditions
AbstractHIV-associated neurocognitive disorder (HAND) is a common complication of HIV infection, whose development is known to be facilitated by inflammation and exacerbated by morphine. Previously, using the gp120 transgenic (tg) mouse model in combination with LP-BM5 (a murine retrovirus that can cause systemic immunodeficiency in susceptible mouse strains) we demonstrated differential gp120-associated central nervous system (CNS) neuroinflammatory responses under immunocompetent (-LP-BM5) vs. immunocompromised (+LP-BM5) conditions. Here, we further investigated the effects of morphine on gp120-associated neuroinflammato...
Source: Journal of NeuroImmune Pharmacology - January 21, 2022 Category: Drugs & Pharmacology Source Type: research

From Initiation to Maintenance: HIV-1 Gp120-induced Neuropathic Pain Exhibits Different Molecular Mechanisms in the Mouse Spinal Cord Via Bioinformatics Analysis Based on RNA Sequencing
AbstractHuman immunodeficiency virus (HIV), which causes acquired immunodeficiency syndrome (AIDS), remains one of the most diverse crucial health and development challenges around the world. People infected with HIV constitute a large patient population, and a significant number of them experience neuropathic pain. To study the key mechanisms that mediate HIV-induced neuropathic pain (HNP), we established an HNP mouse model via intrathecal injection of the HIV-1 envelope glycoprotein gp120. The L3~L5 spinal cord was isolated on postoperative days 1/12 (POD1/12), 1 (POD1), and 14 (POD14) for RNA sequencing to investigate t...
Source: Journal of NeuroImmune Pharmacology - January 21, 2022 Category: Drugs & Pharmacology Source Type: research

Oligosaccharide and Flavanoid Mediated Prebiotic Interventions to Treat Gut Dysbiosis Associated Cognitive Decline
In conclusion, XOS and quercetin effectively reduced antibiotic associated gut dysbiosis and prevented gut dysbiosis associated cognitive decline in mice.Graphic Abstract (Source: Journal of NeuroImmune Pharmacology)
Source: Journal of NeuroImmune Pharmacology - January 19, 2022 Category: Drugs & Pharmacology Source Type: research

Aging Accelerates Postural Instability in HIV Infection: Contributing Sensory Biomarkers
AbstractPeople living with HIV infection (PWH) who are adequately treated pharmacologically are now likely to have a near normal life span. Along with this benefit of the aging HIV population are potential physical problems attendant to aging, including postural stability. Whether aging with HIV accelerates age-related liability for postural instability and what sensory factors contribute to imbalance were examined in 227 PWH and 137 people living without HIV (PWoH), age 25 to 75  years. A mixed cross-sectional/longitudinal design revealed steeper aging trajectories of the PWH than PWoH in sway path length, measured as ce...
Source: Journal of NeuroImmune Pharmacology - January 8, 2022 Category: Drugs & Pharmacology Source Type: research

Opioid Use, Gut Dysbiosis, Inflammation, and the Nervous System
AbstractOpioid use disorder (OUD) is defined as the chronic use or misuse of prescribed or illicitly obtained opioids and is characterized by clinically significant impairment. The etiology of OUD is multifactorial as it is influenced by genetics, environmental factors, stress response and behavior. Given the profound role of the gut microbiome in health and disease states, in recent years there has been a growing interest to explore interactions between the gut microbiome and the central nervous system as a causal link and potential therapeutic source for OUD. This review describes the role of the gut microbiome and opioi...
Source: Journal of NeuroImmune Pharmacology - January 7, 2022 Category: Drugs & Pharmacology Source Type: research

Higher Levels of IgG3 Antibodies in Serum, But Not in CSF, Distinguish Multiple Sclerosis From Other Neurological Disorders
AbstractIncreased intrathecal IgG and oligoclonal bands (OCB) are seminal features of multiple sclerosis (MS). Although no such differences in MS blood total IgG antibodies have been reported, serum OCB are a common and persistent finding in MS and have a systemic source. Recent studies showed that IgG3+ B cells and higher levels of serum IgG3 are linked to the development of MS. Additionally, intrathecal IgG synthesis in MS is associated with IgG3 heavy chain gene single nucleotide polymorphisms, and there is a strong relationship between susceptibility to MS and an IgG3 restriction fragment len gth polymorphism. These ...
Source: Journal of NeuroImmune Pharmacology - January 6, 2022 Category: Drugs & Pharmacology Source Type: research

Cognitive Phenotypes of HIV Defined Using a Novel Data-driven Approach
AbstractThe current study applied data-driven methods to identify and explain novel cognitive phenotypes of HIV. Methods: 388 people with HIV (PWH) with an average age of 46 (15.8) and median plasma CD4+ T-cell count of 555 copies/mL (79% virally suppressed) underwent cognitive testing and 3T neuroimaging. Demographics, HIV disease variables, and health comorbidities were recorded within three months of cognitive testing/neuroimaging. Hierarchical clustering was employed to identify cognitive phenotypes followed by ensemble machine learning to delineate the features that determined membership in the cognitive phenotypes. H...
Source: Journal of NeuroImmune Pharmacology - January 4, 2022 Category: Drugs & Pharmacology Source Type: research

Inhibition of Microglial NLRP3 with MCC950 Attenuates Microglial Morphology and NLRP3/Caspase-1/IL-1 β Signaling In Stress-induced Mice
In conclusion, this study demonstrates that microglial NLRP3 inhibition prevents stress-induced neuroinflammation in the prefrontal cortex and suggests that microglial NLRP3 could be one o f the potential therapeutic targets for depression treatment.Graphic Abstract (Source: Journal of NeuroImmune Pharmacology)
Source: Journal of NeuroImmune Pharmacology - January 3, 2022 Category: Drugs & Pharmacology Source Type: research

The Neuroimmune Pharmacology of SARS-CoV-2
AbstractThis guest commentary introduces “The Neuroimmune Pharmacology of SARS-CoV-2,” a special theme issue forThe Journal of Neuroimmune Pharmacology led by the Society on NeuroImmune Pharmacology. The issue builds on the Society ’s Virtual Workshop on COVID-19 held April 9, 2021.Graphical abstractTop row from left: Drs. Santosh Kumar, Sowmya Yelamanchili, Pankaj Seth, Jean M. Bidlack; Bottom row from left: Drs. Gurudutt Pendyala, Sanjay Maggirwar, and Sulie L. Chang. (Source: Journal of NeuroImmune Pharmacology)
Source: Journal of NeuroImmune Pharmacology - December 22, 2021 Category: Drugs & Pharmacology Source Type: research

Correction to: Mitochondrial Dynamics in SARS ‑COV2 Spike Protein Treated Human Microglia: Implications for Neuro‑COVID
(Source: Journal of NeuroImmune Pharmacology)
Source: Journal of NeuroImmune Pharmacology - December 11, 2021 Category: Drugs & Pharmacology Source Type: research

Melatonin: Revisited Role as Vaccine Adjuvant During Outbreaks of COVID-19 Caused by the Delta Variant
(Source: Journal of NeuroImmune Pharmacology)
Source: Journal of NeuroImmune Pharmacology - November 30, 2021 Category: Drugs & Pharmacology Source Type: research