18 Intermittent hypoxia improves atherosclerosis associated with upregulation of hif-1{alpha} and nf-{kappa}b in aortic arch and serum of rabbits
ConclusionsIH may, through increased HIF-1α and NF-B in rabbits, lead to lipid deposition, which leads to the formation of atherosclerosis and the occurrence of cardiovascular and cerebrovascular diseases. (Source: Journal of Investigative Medicine)
Source: Journal of Investigative Medicine - December 5, 2017 Category: Research Authors: Pang, J., Wang, B., Li, Y., Zhang, H., Xiang, W., Hao, X., Xue, H. Tags: Abstracts Source Type: research
17 Effect of salvia miltiorrhiza on tmmrna expression in coronary artery tissue of rats with high salt induced blood stasis
Conclusion Salvia miltiorrhiza can reduce the expression of TMmRNA in the tissue of blood stasis caused by high salt, promote the repair of blood vessel endothelium and blood movement, and can effectively improve the damaged coronary artery.AcknowledgementsSupported by a project grant from Natural Science Foundation of China (Grant No. 81503476). (Source: Journal of Investigative Medicine)
Source: Journal of Investigative Medicine - December 5, 2017 Category: Research Authors: Xia, L., Zhou, X., Tian, X., Zhao, Y., Fu, D., Xu, H. Tags: Abstracts Source Type: research
16 The intervention effect of total flavonoids of mao dongqing on cerebral ischaemic tolerance model in mice
ConclusionIschaemic preconditioning can induce cerebral ischaemic tolerance. The total flavonoids of Mao Dongqing and ischaemic preconditioning have a synergistic effect by inhibition of the overexpression of immediate early gene c-fos, COX-2 and improved platelet function. It can reduce brain injury and promote the formation of cerebral ischaemic tolerance. (Source: Journal of Investigative Medicine)
Source: Journal of Investigative Medicine - December 5, 2017 Category: Research Authors: Lou, X., Bai, M., Qiao, J., Fang, X., Miao, M. Tags: Abstracts Source Type: research
15 Comparison of biomechanical characteristics on barefoot running and shod running
BackgroundCompared with the rearfoot strike pattern of shod running, barefoot running with a forefoot strike pattern will change the kinematics and kinetic parameters. This paper analyses the biomechanical differences between barefoot running and shod running and aims to provide a reference for barefoot training and the prevention of sports injury.MethodsThree-dimensional force plate test and three-dimensional video analysis.ResultsKinetic characteristics: The F-t curve by the force plate test shows that barefoot running has a smooth curve with a single peak while the F-t curve of shod running has a double peak on the vert...
Source: Journal of Investigative Medicine - December 5, 2017 Category: Research Authors: Wang, S., Zhou, J. Tags: Abstracts Source Type: research
14 The mechanism of pkcB-p66shc-nadph oxidase pathway in high glucose induced-oxidative stress in renal tubular epithelial cells
ConclusionThe study clarified a novel mechanism of oxidative stress damaging HK-2 cells via the modulation of the PKCβ-P66Shc-NADPH oxidase pathway. Understanding the molecular pathway of oxidative stress could translate into the development of therapeutic strategies for diabetic nephropathy.AcknowledgementsThis work was supported by the National Natural Science Foundation of China [No. 81400300] and Natural Science Foundation of Jiangsu Province [No. BK20130642]. (Source: Journal of Investigative Medicine)
Source: Journal of Investigative Medicine - December 5, 2017 Category: Research Authors: Cheng, Y., Chao, J., Zhu, D., Liu, B. Tags: Abstracts Source Type: research
13 Atp-sensitive potassium channels mediate the cardioprotection of panax notoginseng saponins against myocardial ischemia reperfusion injury and inflammatory reaction
ConclusionPNS preconditioning may reduce inflammation to due to MIRI via KATP channels.AcknowledgementsSupported by a project grant from National Natural Science Foundation (NSFC) of China (Grant No. 81303256). (Source: Journal of Investigative Medicine)
Source: Journal of Investigative Medicine - December 5, 2017 Category: Research Authors: Ning, K., Jiang, L., Yang, Z., Zheng, Q., Bao, Y. Tags: Abstracts Source Type: research
12 The igca staging system compared with ajcc7 system in stratifying survival of patients with cancer
ConclusionsThe IGCA staging system can stratify stage III gastric cancer patients more correctly than the AJCC7 system.AcknowledgementSupported by the National Natural Science Foundation of China (Grant No. 14B520013) and the Scientific Research Project from the open fund of Henan Key laboratory (Grant No. 172400410344). (Source: Journal of Investigative Medicine)
Source: Journal of Investigative Medicine - December 5, 2017 Category: Research Authors: Wang, F. Tags: Abstracts Source Type: research
11 Meta-analysis of prognostic value of transforming growth factor-beta (tgf-{beta}) in patients
ConclusionsThis meta-analysis demonstrates that TGF-β can be used as a prognostic biomarker for CRC patients undergoing surgery, especially for CRC patients from Western countries. (Source: Journal of Investigative Medicine)
Source: Journal of Investigative Medicine - December 5, 2017 Category: Research Authors: Wang, F. Tags: Abstracts Source Type: research
10 Knockdown of transforming growth factor beta regulator 4 (tbrg4) promotes apoptosis in human lung cancer cell line h1299 via regulating ddit3, cav1 and rrm2
AbstractTransforming growth factor beta regulator 4 (TBRG4) gene is located on 7 p14-p13, a region correlated with many cancer types, such as hematologic malignancies, head and neck squamous cell carcinoma, and multiple myeloma. However, the role of TBRG4 in human lung cancer is largely unknown. Thus, in the present study, the TBRG4 mRNA level was evaluated in the lung cancer cell line H1299 by quantitative PCR (qPCR) after knocking down TBRG4 using lentivirus-mediated small interfering RNA (siRNA). The result showed that TBRG4 was significantly inhibited in H1299 by RNAi. Microarray analysis revealed 586 differentially-ex...
Source: Journal of Investigative Medicine - December 5, 2017 Category: Research Authors: Wang, A., Liu, X., Su, W., Duan, G., Xie, Z., Chu, S. Tags: Abstracts Source Type: research
09 Exploring the genotype-phenotype associations of colorectal cancer using vector space model
ConclusionOur study provides a biomedical literature mining method for cancer translational research such as construction of a precision medicine knowledge base, biomarker prediction/evaluation, and knowledge discovery in texts.AcknowledgementsSupported by the National key research and development program of China (No. 2016YFC0901703), and the Public Projects of Zhejiang Province, China (No. 2017C33064). (Source: Journal of Investigative Medicine)
Source: Journal of Investigative Medicine - December 5, 2017 Category: Research Authors: Deng, N., NK, D., Feng, Y., Wang, Z., Duan, H., Liu, F. Tags: Abstracts Source Type: research
08 Study of total flavonoids from mao dongqing in cerebral ischemia reperfusion models
ConclusionThe results of this study showed that the model of cerebral ischemia-reperfusion in mice was successful. The total flavonoids from MDQ could achieve the role of anti-cerebral ischemia injury by inhibition of the inflammatory cascade, improving the imbalance of oxygen supply and demand and the disorder of glucose metabolism, inhibiting the apoptosis of nerve cells during cerebral ischemia reperfusion injury.AcknowledgmentNational "Significant New Drug Creation" science and technology major special project (2009Z x 09103-324). (Source: Journal of Investigative Medicine)
Source: Journal of Investigative Medicine - December 5, 2017 Category: Research Authors: Miao, M., Cao, L., Qiao, J., Zheng, Y., Xin, W. Tags: Abstracts Source Type: research
07 The approach to generate oncolytic adenovirus by sirna mediated e1b silencing
ConclusionIn addition to knockout of the E1B coding cassette, siRNA mediated E1B also serves as an approach to prepare oncolytic adenovirus.AcknowledgementsSupported by grants from UICC (ICRETT Fellowship), Guangdong Commission of Health and Family Plan (Grant No. 2014A276). (Source: Journal of Investigative Medicine)
Source: Journal of Investigative Medicine - December 5, 2017 Category: Research Authors: Zhang, X., Matskova, L., Zheng, B., Ernberg, I., He, Z., Huang, Z. Tags: Abstracts Source Type: research
06 Hemicellulose-based magnetic hydrogel for enzyme drug immobilisation
ConclusionThe swelling property and high immobilisation capacity of HC/PAAc semi-IPN magnetic hydrogel could expand its applications in drug delivery.AcknowledgementsSupported by Natural Science Basic Research Plan in Shaanxi Province of China (No. 2017JM2003), and the Seed Foundation of Innovation and Creation for Graduate Students in Northwestern Polytechnical University (No. Z2017204). (Source: Journal of Investigative Medicine)
Source: Journal of Investigative Medicine - December 5, 2017 Category: Research Authors: Ma, J., Sun, X., Yao, X., Zeng, Q. Tags: Abstracts Source Type: research
05 Core-shell medicated nanoparticles prepared using coaxial electrospray for fast dissolution of paracetamol
ConclusionCore-shell medicated nanoparticles prepared using coaxial electrospray can be an alternative approach for improving the dissolution rate of insoluble drugs.AcknowledgementsSupported by the National Natural Science Foundation of China (No. 51373101). (Source: Journal of Investigative Medicine)
Source: Journal of Investigative Medicine - December 5, 2017 Category: Research Authors: Li, H., Zhang, L., Zhang, Y., DG, Y. Tags: Abstracts Source Type: research
04 Construction and analysis of lair-1 over-expressed nk-92 cells
ConclusionLAIR-1 over-expressed NK-92 cells were constructed successfully and the IL-2 treatment experiment showed different roles of STAT1 and STAT4 in the regulation of NK cells.AcknowledgementsSupported by a project grant from the Natural Science Foundation of Shandong Province (ZR2015JL027) and National Natural Science Foundation of China (81370730, 81571512, 81273200, and 31300751). (Source: Journal of Investigative Medicine)
Source: Journal of Investigative Medicine - December 5, 2017 Category: Research Authors: Fu, Q., Sun, Y., Xue, J., Piao, H., Du, M., Li, D. Tags: Abstracts Source Type: research
