Saying goodbye and remembering
(Source: Journal of Investigative Medicine)
Source: Journal of Investigative Medicine - December 1, 2022 Category: Research Authors: McCallum, R. W. Tags: Editorial Source Type: research
Author index
(Source: Journal of Investigative Medicine)
Source: Journal of Investigative Medicine - October 3, 2022 Category: Research Tags: Abstracts Source Type: research
Midwest Clinical and Translational Research Meeting of CSCTR and MWAFMR
(Source: Journal of Investigative Medicine)
Source: Journal of Investigative Medicine - October 3, 2022 Category: Research Tags: Abstracts Source Type: research
Effect of intramuscular depot betamethasone injection in patients with fibromyalgia and elevated C-reactive protein levels
Fibromyalgia is characterized by diffuse musculoskeletal pain and fatigue. There are limited data about systemic steroid treatment of patients with fibromyalgia in the English literature. Patients with fibromyalgia with ongoing diffuse musculoskeletal pain despite standard treatment, extreme fatigue and elevated C-reactive protein (CRP) levels without evidence of synovitis, or other source of inflammation, were asked to participate in our study. After consent, demographic, clinical and laboratory parameters in addition to body mass index were documented. These patients were interviewed and asked to answer the Revised Fibro...
Source: Journal of Investigative Medicine - October 3, 2022 Category: Research Authors: Dirawi, N., Habib, G. Tags: Brief report Source Type: research
Is blood lymphocyte count a prognostic biomarker in Staphylococcus aureus bacteremia?
Lymphopenia is common in patients with sepsis and associated with mortality. Immune-stimulatory therapies likely to restore T-cells count and function are under investigation in sepsis. Our study aimed to assess whether lymphopenia is a reliable prognostic biomarker in Staphylococcus aureus bacteremia. We conducted an ancillary study of the prospective VIRSTA Study including 574 patients with S. aureus bacteremia in two tertiary care centers. Neither lymphocyte count at the onset nor lymphocyte change during the first 4 days was associated with 12-week mortality. These results highlight the importance of characterizing the...
Source: Journal of Investigative Medicine - October 3, 2022 Category: Research Authors: Blot, M., Zeggay, A., Aho-Glele, L.-S., Laborde, C., Le Moing, V., Chirouze, C., Bouiller, K., Piroth, L. Tags: Brief report Source Type: research
Patterns and seasonality in pediatric referrals for functional somatic symptoms
In conclusion, FSS account for 1 in 10 non-acute pediatric referrals, without an increase in incidence in the past 6 years. The seasonal pattern is remarkable and warrants further analysis. (Source: Journal of Investigative Medicine)
Source: Journal of Investigative Medicine - October 3, 2022 Category: Research Authors: den Braber, P., van Driel, J., Broekhuijsen, D., Wienen, B., Bekhof, J. Tags: Original research Source Type: research
Construction and validation of an autophagy-related long non-coding RNA signature to predict the prognosis of kidney renal papillary cell carcinoma
To identify the autophagy-related long non-coding RNAs (ARlncRNAs) associated with the prognosis of kidney renal papillary cell carcinoma (KIRP), thereby establishing a clinical prognostic model. The gene expression matrix and clinical survival information of patients with KIRP were downloaded from The Cancer Genome Atlas database, and were divided into the training and testing groups. ARlncRNAs associated with the KIRP prognosis were analyzed by univariate, Least Absolute Shrinkage and Selection Operator (LASSO(, and multivariate Cox regression to construct a signature. We combined clinical factors associated with the pro...
Source: Journal of Investigative Medicine - October 3, 2022 Category: Research Authors: Kang, Z., Yang, J. Tags: Original research Source Type: research
Comparing the effects of twice-daily exenatide and insulin on renal function in patients with type 2 diabetes mellitus: secondary analysis of a randomized controlled trial
This is a secondary analysis of a randomized controlled trial (RCT) on the effects of the glucagon-like peptide-1 receptor agonists exenatide and insulin aspartate 30 injection on carotid intima-media thickness. Here, we report the renal outcomes of the intervention in patients with type 2 diabetes mellitus (T2DM). Data from the RCT study was used to evaluate the effect of exenatide or insulin given for 52 weeks on estimated glomerular filtration rate (eGFR) in patients with T2DM. The primary end point was the change in the eGFR from baseline between the exenatide and insulin groups in normal versus overweight patients and...
Source: Journal of Investigative Medicine - October 3, 2022 Category: Research Authors: Zhang, J., Xian, T.-Z., Wu, M.-X., Li, C., Wang, W., Man, F., Zhang, X., Wang, X., Pan, Q., Guo, L. Tags: Original research Source Type: research
Natriuretic peptides, extracellular volume, and subclinical cardiovascular changes in chronic kidney disease stages 1-3: a pilot study
Natriuretic peptide levels are elevated in persons with chronic kidney disease (CKD) stages 1–3, but it remains unclear whether this is associated with extracellular volume excess or early cardiovascular changes. We hypothesized that patients with CKD stages 1–3 would have evidence of cardiovascular changes, which would associate with brain natriuretic peptide (BNP), amino-terminal-pro-BNP (NT-pro-BNP), and patient-reported symptoms.
Outpatients with CKD stages 1–3 and non-CKD controls were enrolled. Cardiovascular parameters included extracellular water (ECW) normalized to body weight measured using whol...
Source: Journal of Investigative Medicine - October 3, 2022 Category: Research Authors: Gregg, L. P., Van Buren, P. N., Ramsey, D. J., Maydon, A., Banerjee, S., Walther, C. P., Virani, S. S., Winkelmayer, W. C., Navaneethan, S. D., Hedayati, S. S. Tags: Original research Source Type: research
Association of intermittent versus continuous hemodialysis modalities with mortality in the setting of acute stroke among patients with end-stage renal disease
Patients with end-stage renal disease (ESRD) are 8–10 times more likely to suffer from a stroke compared with the general public. Despite this risk, there are minimal data elucidating which hemodialysis modality is best for patients with ESRD following a stroke, and guidelines for their management are lacking. We retrospectively queried the US Renal Data System administrative database for all-cause mortality in ESRD stroke patients who received either intermittent hemodialysis (IHD) or continuous renal replacement therapy (CRRT). Acute ischemic stroke and hemorrhagic stroke were identified using the International Cla...
Source: Journal of Investigative Medicine - October 3, 2022 Category: Research Authors: Morgan, M. C., Waller, J. L., Bollag, W. B., Baer, S. L., Tran, S., Kheda, M. F., Young, L., Padala, S., Siddiqui, B., Mohammed, A. Tags: Original research Source Type: research
Impact of family history of coronary artery disease on clinical outcomes in Takotsubo cardiomyopathy
Family history of coronary artery disease (FHxCAD) is a critical risk factor for CAD, underscoring the contribution of genetic factors to disease pathogenesis and susceptibility. Takotsubo cardiomyopathy (TCM) simulates the clinical features of and frequently coexists with CAD. However, the association between FHxCAD and TCM is unclear. Here, we retrospectively examined the impact of FHxCAD on in-hospital outcomes of patients with TCM. Using the National Inpatient Sample database (2016–2018), we identified 4733 patients admitted to hospital with a primary diagnosis of TCM. We compared in-hospital outcomes and complic...
Source: Journal of Investigative Medicine - October 3, 2022 Category: Research Authors: Li, P., Jin, C., Cui, C., Cai, P., Manohar, S. A., Jin, L., Wei, X., Pan, S., Dixon, R. A. F., Liu, Q. Tags: Original research Source Type: research
MHR and NHR but not LHR were associated with coronary artery disease in patients with chest pain with controlled LDL-C
In conclusion, even though patients with chest pain have achieved LDL-C <1.8 mmol/L, the inflammatory indicators MHR and NHR maintained their predictive abilities and remained associated with the occurrence and severity of CAD. (Source: Journal of Investigative Medicine)
Source: Journal of Investigative Medicine - October 3, 2022 Category: Research Authors: Liu, M., Liu, X., Wei, Z., Hua, R., Huang, Y., Hao, X., Yuan, Z., Zhou, J. Tags: Original research Source Type: research
High-risk human papillomavirus infection in pregnant women: a descriptive analysis of cohorts from two centers
The aim was to descriptively analyze the clinical characteristics, cytopathology, and outcomes of pregnant patients with high-risk human papillomavirus (HPV) infection. Clinical data of 151,516 female patients with high-risk HPV infection were retrospectively collected. Baseline data, cervical cytology results, histopathology, HPV types, delivery mode, and follow-up outcomes were recorded for descriptive analysis. A total of 157 patients were identified as positive for high-risk HPV. There were 32 (24.2%), 6 (4.5%), and 107 (81.1%) cases of HPV-16, HPV-18, and other types, respectively. Additionally, 12 patients showed com...
Source: Journal of Investigative Medicine - October 3, 2022 Category: Research Authors: Liu, J., Li, Y., Bo, D., Wang, J., Wang, Y. Tags: Original research Source Type: research
Management of deep neck infections in adults and importance of clinical and laboratory findings
This study aimed to analyze laboratory and radiological imaging results in the prediction of treatment strategy in patients with deep neck infections. Eighty-three patients (55 (66.3%) men, mean age: 38.2±14.5 years) were included in the study. Patients were divided into three groups according to the treatment strategy: group 1 received only antibiotic treatment, group 2 underwent abscess drainage with needle puncture in addition to antibiotic treatment, and group 3 underwent surgical drainage with antibiotic treatment. Laboratory outcomes, imaging methods, duration of hospital stay, treatment strategy, and clinical...
Source: Journal of Investigative Medicine - October 3, 2022 Category: Research Authors: Arslan, H., Bayır, O., Aksoy, S., Keseroglu, K., Saka, C., Tatar, E. C., Saylam, G., Korkmaz, M. H. Tags: Original research Source Type: research
COVID-19 pneumonia in patients with impaired fasting glucose, newly diagnosed diabetes and pre-existing diabetes: a tertiary center experience
COVID-19 infection is known to increase mortality in patients with diabetes. We aim to demonstrate the differences in disease course and clinical outcomes of patients with COVID-19 regarding the presence of impaired fasting glucose, pre-existing diabetes mellitus (DM) or new-onset DM. 236 patients with positive reverse transcription-PCR tests for SARS-CoV-2 were included in this single-center, retrospective observational study between March 2020 and May 2021. Laboratory results, comorbidities, medications and imaging findings were noted. Logistic regression was used to estimate associated factors for admission to the inten...
Source: Journal of Investigative Medicine - October 3, 2022 Category: Research Authors: Boyuk, B., Akin, S., Aladag, N., Isik, A., Erman, H., Ozgur, Y., Topal, M., Karademir, N., Tomar Uysal, B., Ozbilgehan, B., Kabaca, D., Kalmaz, C., Arslan, S., Keskin, O. Tags: COVID-19 Original research Source Type: research
